A5013670429- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Blood groups and transfusion
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Protein purification and stability
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Pregnancy and Medication Impact
- Cutaneous lymphoproliferative disorders research
- Endometriosis Research and Treatment
- Protein Degradation and Inhibitors
- T-cell and B-cell Immunology
- Estrogen and related hormone effects
SUNY Upstate Medical University
2007-2024
Upstate University Hospital
2022-2023
University of Buenos Aires
2007-2018
Consejo Nacional de Investigaciones Científicas y Técnicas
2004-2018
Institute of Astronomy and Space Physics
1995-2015
State University of New York
1995-2012
Syracuse University
1995-2010
Weatherford College
2009
University of Naples Federico II
2008
City Of Hope National Medical Center
2006
Data are lacking on whether lenalidomide maintenance therapy prolongs the time to disease progression after autologous hematopoietic stem-cell transplantation in patients with multiple myeloma.
Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy.This double-blind study compared effect that placebo on development in 212 patients hematologic cancers; 106 received (60 microg per kilogram body weight day) intravenously for three consecutive days immediately before initiation conditioning therapy...
Purpose To describe patient-reported outcomes of mouth and throat soreness (MTS) related sequelae on daily activities from a phase III study palifermin in the autologous hematopoietic stem-cell transplantation (HSCT) setting to compare patient self-evaluations with clinicians' assessments oral mucositis using objective scales. Patients Methods (n = 212) received (60 μg/kg/d) or placebo for 3 days before total-body irradiation (12 Gy), etoposide 60 mg/kg, cyclophosphamide 100 after HSCT....
Individuals with an underlying malignancy have high risk of poor COVID-19 outcomes. In clinical trials, vaccines were safe and efficacious against infection, hospitalization, death, but most trials excluded participants cancer. We report results from a history past or active neoplasm (malignant benign/unknown) up to 6 months' follow-up post-dose 2 the placebo-controlled, observer-blinded trial 2-dose BNT162b2 mRNA vaccine.Between July 2020-January 2021, 46,429 aged ≥ 12 years randomized at...
Trophoblast invasion is a temporally and locally restricted process, which regulates implantation oxygen arrival to the embryo through dialog with spiral artery endothelium. factors angiogenic potential are activated by hypoxia. Their capacities induce proliferation, migration, of trophoblastic cells have been investigated.The expression interleukin (IL)-6, CD126, CD130, vascular endothelial growth factor (VEGF), hypoxia inducible factor-1alpha (HIF-1alpha) has silenced in JEG-3...
<b><i>Aim:</i></b> Catecholamines regulate functions of the nervous, neuroendocrine and immune systems. Dopamine may modulate activity keratinocytes, which play a role in secreting cytokines chemokines. The aim this study was to evaluate effect dopaminergic agonists on production IL-6 IL-8 by non-tumoral human keratinocyte cell line (HaCaT). <b><i>Methods:</i></b> Cells were stimulated with dopamine D<sub>2</sub> receptor agonist...
PROBLEM: Asymmetric IgG antibodies (AAb) possess a mannose‐rich oligosaccharide residue bound to one of the Fab regions, making them unable activate immunoeffector mechanisms. The proportion asymmetric is increased after prolonged immunization with particulate antigens like cellular spleen cells. During pregnancy, AAb were found in serum and placenta specific activity paternal antigens. No previous reports about status recurrent spontaneous abortion (RSA) patients have been published date....
Canellada A, Blois S, Gentile T, Margni Idehu RA. In vitro modulation of protective antibody responses by estrogen, progesterone and interleukin‐6. AJRI 2002; 48:334–343 © Blackwell Munksgaard, 2002 PROBLEM: We have previously demonstrated that the addition placental interleukin‐6 (IL‐6) to murine hybridomas increased asymmetric synthesis. Here we analyze whether (Pg) estrogen (E 2 ) affect synthesis modulating IL‐6 production in hybridoma cells. METHOD OF STUDY: Hybridoma 112D5 B cells were...
Citation Junovich G, Mayer Y, Azpiroz A, Daher S, Iglesias Zylverstein C, Gentile T, Pasqualini Markert UR, Gutiérrez G. Ovarian stimulation affects the levels of regulatory endometrial NK cells and angiogenic cytokine VEGF. Am J Reprod Immunol 2011; 65: 146–153 Problem Endometrial play a critical role in uterine vascularization producing factors. Impact ovarian on expression VEGF normal fertile oocyte donors effect injury treatment these parameters have been investigated. Method study...
Sera from approximately 50% of patients with large granular lymphocyte (LGL) leukaemia react a recombinant human T‐cell leukaemia/lymphoma virus (HTLV) transmembrane envelope protein, p21e. Two immunodominant epitopes within env p21e have been defined by reactivity against proteins GD21 and BA21. In this study sera 41 LGL were examined for these HTLV proteins. Overall, 21/41 (51%) reacted to Only two GD21. The predominant immunoreactivity was directed the BA21 epitope, 19/41 (46%) being...
Abstract N 6 ‐isopentenyladenosine (i6A) is a modified nucleoside with pentaatomic isopentenyl derived from mevalonate that induces inhibition of tumor cell proliferation and apoptosis in several lines. In this study, we reported inhibited the promotes DLD1 human colon cancer cells. It suppressed cells through DNA synthesis, causing cycle arrest correlated decrease levels cyclin E, A D1 concomitant increase cyclin‐dependent kinase inhibitor p21waf p27kip1. Moreover, it induced an number...
Post‐transplantation lymphoproliferative disorders (PTLD) are a clinicopathologically heterogenous group of lymphoid proliferations. The majority B‐cell origin and associated with Epstein‐Barr virus (EBV) infection. In contrast, the development T‐cell PTLD is much less common EBV does not appear to be involved in pathogenesis. this report we describe three patients who developed large granular lymphocyte (LGL) leukaemia after renal transplantation. These had clonal expansion CD3 + , CD8 CD57...
Problem: DBA/2J‐mated CBA/J female mice are prone to a high incidence of fetal abortions. This wastage can be dramatically reduced by immunizing the with BALB/c, but not DBA/2J spleen cells during early gestation. Nevertheless, underlying mechanisms remain elucidated. Recently, dendritic (DC) have been described at feto‐maternal interface in human uterus. In this work, we studied effect adoptive transfer DC on maintenance pregnancy × model. Methods: Bone marrow‐derived were generated from...
Canellada A, Färber Zenclussen AC, Gentile T, Dokmetjian J, Keil Blois S, Miranda Berod L, Gutiérrez G, Markert UR, Margni RA. Interleukin regulation of asymmetric antibody synthesized by isolated placental B cells. AJRI 2002; 48: 275–282 © Blackwell Munksgaard, 2002 PROBLEM: Protecting antibodies against trophoblast surface molecules were previously described. Here we analysed the synthesis IgG B‐lymphocytes. METHOD OF STUDY: cells from human term placenta and cord blood, stimulated with...
Cyclooxygenase (COX)-2, the inducible isoform of cyclooxygenase, plays a role in process uterine decidualization and blastocyst attachment. On other hand, overexpression COX-2 is involved proliferation endometrial tissue during endometriosis. Deregulation renin-angiotensin-system pathophysiology endometriosis pre-eclampsia. Angiotensin II increases intracellular Ca(2+) concentration by targeting phospholypase C-gamma stromal cells (ESC). A key element cellular response to signals activity...