A5046930858- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- HIV, TB, and STIs Epidemiology
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Cancer-related Molecular Pathways
- Sex work and related issues
- Biochemical and Molecular Research
- COVID-19 impact on air quality
- Building Energy and Comfort Optimization
- Galectins and Cancer Biology
- T-cell and Retrovirus Studies
- Liver Disease Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Viral-associated cancers and disorders
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- COVID-19 diagnosis using AI
- Climate Change and Health Impacts
- COVID-19 epidemiological studies
Lund University
2022-2025
Karolinska Institutet
2019
Republican Research and Practical Center for Epidemiology and Microbiology
2011-2018
Transmission of coronavirus disease 2019 (COVID-19) can occur through inhalation fine droplets or aerosols containing infectious virus. The objective this study was to identify situations, patient characteristics, environmental parameters, and aerosol-generating procedures (AGPs) associated with airborne severe acute respiratory syndrome 2 (SARS-CoV-2)
HIV drug resistance (HIVDR) presents a significant challenge to antiretroviral therapy (ART) success, particularly in resource-limited settings like Ethiopia. This cross-sectional study investigated viral suppression rates and patterns among patients on second-line ART across 28 Ethiopian health facilities. Blood samples collected from 586 participants were analyzed measure CD4 count load assess HIVDR experiencing virological failure (VF) (viral ≥ 1000 copies/mL). Demographic clinical data...
Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing countries, including Ethiopia. However, subtype-dependent polymorphic differences might influence the occurrence of HIV-drug-resistance mutations (HIVDRMs). We analyzed prevalence pre-treatment integrase strand transfer inhibitor (INSTI) HIVDRMs and naturally occurring polymorphisms (NOPs) gene, using plasma samples collected as part national HIVDR survey Ethiopia 2017. included a total 460 HIV-1 gene...
HIV-induced immune suppression results in the high prevalence of HIV/AIDS-associated malignancies including Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer. HIV-infected people are also at an increased risk “non-AIDS-defining” not directly linked to but associated with viral infections. Their incidence is increasing despite successful antiretroviral therapy. The mechanism behind this phenomenon remains unclear. Here, we obtained daughter clones murine mammary gland adenocarcinoma...
Background . Airborne SARS‐CoV‐2 plays a prominent role in COVID‐19 transmission. Numerous studies have sampled air from patient rooms, but airborne spread to other hospital areas such as corridors is less investigated. Methods Size‐fractionated aerosol particles were collected weekly, with 12 hours of sampling time daily, at two infectious disease wards southern Sweden between March 2020 and May 2021. Samples analysed real‐time reverse transcription polymerase chain reaction (RT‐qPCR) for...
Targeted viral load (VL) testing has been proposed for antiretroviral treatment (ART) monitoring in resource-limited settings. In this study, we have investigated the performance of host biomarker galectin-9 (Gal-9), alone and combination with interferon-γ-inducible protein 10 (IP-10), identifying individuals at increased likelihood viremia during ART.Cohort HIV-positive adults receiving ART Ethiopian health centers.We included participants detectable (VL ≥150 copies/mL) 12 months after...
The new HIV-1 recombinant, with a Bgag ApolAenv structure, is described. This recombinant virus differs from the classical “Kaliningrad” (AF193276.1) an Agag BpolBenv structure. number of HIV cases in Belarus has been increasing past few years. Within 12 months 2010, 1069 infection were registered. Molecular epidemiological investigations have shown that though subtype A (84.5%) still dominates HIV/AIDS patients, quantity CRFs also increased to 7.1%. Although CRF03_AB previously described...
Ethiopia is one of the sub-Saharan countries hit hard by HIV epidemic. Previous studies have shown that subtype C dominates Ethiopian HIV-1 epidemic, but evolutionary and temporal dynamics in not been closely scrutinized. Understanding epidemiological pattern vital to monitor spread, evaluate implement prevention strategies. We analyzed 1,276 polymerase (pol sequences), including 144 newly generated sequences, collected from different parts country 1986 2017. employed state-of-art maximum...
(1) Background: HIV-1 sub-subtype A1 is common in parts of Africa, Russia, former Soviet Union countries, and Eastern Europe. In Pakistan, the predominant subtype. Preliminary evidence suggests that distinct strains are circulating Pakistan; however, an in-depth molecular phylogenetic characterization Pakistan have not been presented. We performed a detailed epidemic using state-of-the-art epidemiology phylodynamics. (2) Methods: A total 143 gag sequences, including 61 sequences generated...
In our previously studies we detect a HIV recombinant form with BgagApolAenv by isolate named Mos. This virus differs from CRF02_AB AgagBpolBenv. For more detailed studying of Mos genome carried out complete sequencing. (Figure (Figure11) Figure 1 Materials and methods HIV-1 RNA was extracted plasma, reverse transcribed, amplified using sets primers designed to span the HIV-1. Contig assembled in SeqMan®, DNAStar. Recombination analysis performed REGA Subtyping Tool....
Results Of 158 HBV HBsAg positive specimens 17 (10,8%) were from patients with acute hepatitis B and 141 (89,2%) chronic B. Among surveyed 83 (43,6%) women 92 (56,4%) men at the age 15 till 90 years. Middle has made 44,5±17,8 From 11 persons have been HBV+HBC co-infected 1 HBV+HCV+HIV. genotypes defined 61 (34,9%) patient. The phylogenetic analysis of preS fragment shown that in 52 (85,3%) cases come to light D genotype (D1 – 32.9%; D2 26,2%, D3 26.2%), 7 (11,5%) A (A2) 2 (3,2%) C (C2)...
ResultsIn April 2010 we have performed resistance tests of plasma sample obtained from patient Mos, 6 years old girl, born HIV-infected mother.The phylogenetic analysis the DNA fragment Mos had shown that has been clustered with HIV-1 subtype A on gene pol, but was different other analyzed samples, consensus IDU-A and reference sequences (AF004885).The isolate is most similar to AF413987 Ukraine (subtype A) p-distance 0.066.The comparison gag p17/ p24 region demonstrates average 0.129, B...