A5079955603- Infection Control and Ventilation
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- COVID-19 impact on air quality
- COVID-19 diagnosis using AI
- Chronic Myeloid Leukemia Treatments
- Air Quality and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- Evacuation and Crowd Dynamics
- Asthma and respiratory diseases
- Surfactants and Colloidal Systems
- Acute Myeloid Leukemia Research
- Building Energy and Comfort Optimization
- Proteins in Food Systems
- Microfluidic and Bio-sensing Technologies
- Renal Transplantation Outcomes and Treatments
- Histone Deacetylase Inhibitors Research
- Occupational exposure and asthma
- Epilepsy research and treatment
- Pharmaceutical studies and practices
- Amyloidosis: Diagnosis, Treatment, Outcomes
Lund University
2021-2025
Design Science (United Kingdom)
2024
Oncopeptides (Sweden)
2017-2020
Melphalan flufenamide (melflufen) is a first-in-class peptide-drug conjugate that targets aminopeptidases and rapidly selectively releases alkylating agents into tumor cells. The phase II HORIZON trial evaluated the efficacy of melflufen plus dexamethasone in relapsed refractory multiple myeloma (RRMM), population with an important unmet medical need.
SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing size distribution virus-containing aerosol particles has been challenging as high concentrations air mainly present close symptom onset. We a case study person with COVID-19 who was able participate extensive measurements already on day onset and then for following three days.Aerosol collection performed using eight-stage impactor while subject breathing, talking singing,...
Transmission of coronavirus disease 2019 (COVID-19) can occur through inhalation fine droplets or aerosols containing infectious virus. The objective this study was to identify situations, patient characteristics, environmental parameters, and aerosol-generating procedures (AGPs) associated with airborne severe acute respiratory syndrome 2 (SARS-CoV-2)
Coronavirus disease 2019 (COVID-19) transmission via exhaled aerosol particles has been considered an important route for the spread of infection, especially during super-spreading events involving loud talking or singing. However, no study previously linked measurements viral emissions to rates.During February-March 2021, COVID-19 cases that were close symptom onset visited with a mobile laboratory collection breathing, talking, and singing, respectively, nasopharyngeal saliva samples....
Transmission of respiratory viruses is a complex process involving emission, deposition in the airways, and infection. Inhalation often most relevant transmission mode indoor environments. For severe acute syndrome coronavirus 2 (SARS-CoV-2), risk inhalation not yet fully understood. Here, we used an aerosol model combined with regional inhaled deposited dose to examine transport aerosols from infected person novel disease (COVID-19) susceptible assess potential rate particles. Two scenarios...
Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An transmission was noted also in many hospitals. We analyzed SARS-CoV-2 room air hospitalized Omicron infected patients and compared results with previous findings pre-Delta variants to study if more prevalent patient rooms after introduction Omicron. Only 4 75 (5%) samples, from 3 43 included patients, were positive early wave, 14/120 (12%), 10 60 initial wave. No certain...
Exhaled SARS-CoV-2-containing aerosols contributed significantly to the rapid and vast spread of covid-19. However, quantitative experimental data on infectivity such is missing. Here, we quantified emission rates infectious viruses in exhaled aerosol from individuals within their first days after symptom onset Six samples three were culturable, which five successfully using TCID50. The source strength was highest during singing, when they 4, 36, or 127 TCID50/s, respectively. Calculations...
Background . Airborne SARS‐CoV‐2 plays a prominent role in COVID‐19 transmission. Numerous studies have sampled air from patient rooms, but airborne spread to other hospital areas such as corridors is less investigated. Methods Size‐fractionated aerosol particles were collected weekly, with 12 hours of sampling time daily, at two infectious disease wards southern Sweden between March 2020 and May 2021. Samples analysed real‐time reverse transcription polymerase chain reaction (RT‐qPCR) for...
e20570 Background: Melflufen is a novel peptide-drug conjugate that rapidly delivers cytotoxic payload into tumor cells. + dex showed efficacy and manageable safety profile in pts with poor-risk, heavily pretreated RRMM the phase 2 HORIZON study (Mateos et al. ASH 2019. Abs. 1883). For RRMM, longer TTNT indicative of disease stabilization clinical benefit associated lower costs (Chen J Manag Care Spec Pharm. 2017). This report after melflufen from is, to our knowledge, first trial population...
Healthcare workers in obstetric clinics may be exposed to airborne SARS-CoV-2 when treating patients with COVID-19.
RMC-035 is a modified version of alpha-1-microglobulin, an endogenous protein developed as renoprotective agent. Its intended use to reduce the risk irreversible loss kidney function in cardiac surgery patients and delayed graft transplant recipients. This first-in-human study aimed evaluate pharmacokinetics safety
Welders are exposed to gas and particle emissions that can cause severe lung disease, such as chronic obstructive pulmonary disease (COPD), a leading of mortality morbidity worldwide. It is difficult detect COPD early therefore mitigating measures may be delayed. The aim this study was investigate health in welders evaluate new sensitive methods with potential assess onset changes occupational settings.This assessed the symptoms active (n = 28) controls 17). Lung measurements were performed...
Background: Despite recent advances in MM therapy, the disease remains incurable. Patients (pts) with late‐stage RRMM refractory to pom and/or dara have limited effective treatment options. Melflufen is a novel peptide‐conjugated alkylator potentiated by intracellular aminopeptidases, which are markedly overexpressed MM. In previous data cut for phase 2 HORIZON study, melflufen + dexamethasone (dex) showed encouraging efficacy pts exposed IMiDs and proteasome inhibitors (PIs) (overall...
Abstract Background: Melflufen is an alkylating peptide belonging to a novel class of peptidase-enhanced compounds. Aminopeptidases are heavily overexpressed and key for the transformation process in multiple myeloma (MM). selectively targets MM through aminopeptidase-driven accumulation, leading 50-fold enrichment metabolites vs melphalan (Chauhan et al. Clin Can Research. 2013). In Phase I/II O-12-M1 study, melflufen showed activity pts with RRMM (overall response rate [ORR], 31%; median...