A5034196135- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
Centro di Riferimento Oncologico
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
BackgroundMetastatic colorectal cancer (CRC) remains a deadly disease. Identifying locally advanced CRC patients with high risk of developing metastasis and improving outcome metastatic require discovering master regulators metastasis. In this context, the non-coding part human genome is still largely unexplored.MethodsTo interrogate disclose metastasis, we combined transposon-based forward genetic screen novel in vitro assay, which forces cells to grow deprived cell-substrate cell-cell...
TP53 is the most frequently mutated gene in human cancers. Most genomic alterations are missense mutations, which cause a loss of its tumour suppressor functions while providing mutant p53 (mut_p53) with oncogenic features (gain-of-function). Loss alters transcription both protein-coding and non-protein-coding genes. Gain-of-function mut_p53 triggers modification expression as well; however, impact on genes whether these affect properties cancer cell lines not fully explored. In this study,...