A5038626831- Microtubule and mitosis dynamics
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Temporomandibular Joint Disorders
- Plant Reproductive Biology
- Plant nutrient uptake and metabolism
- Mitochondrial Function and Pathology
- Nuclear Structure and Function
- Liver Disease Diagnosis and Treatment
- Cephalopods and Marine Biology
- Coral and Marine Ecosystems Studies
- Orthodontics and Dentofacial Orthopedics
- Dermatology and Skin Diseases
- Biocrusts and Microbial Ecology
- Plant Gene Expression Analysis
- Obstructive Sleep Apnea Research
- Facial Trauma and Fracture Management
- Marine Biology and Ecology Research
- Heavy Metal Exposure and Toxicity
- Garlic and Onion Studies
- Endodontics and Root Canal Treatments
- ATP Synthase and ATPases Research
- Plant Stress Responses and Tolerance
- Dysphagia Assessment and Management
- Contact Dermatitis and Allergies
Nagoya University
1982-2023
Okayama University Hospital
2017
Tokushima Bunri University
2014
Pharmaceutical Biotechnology (Czechia)
2014
In-Q-Tel
2014
Okayama University
2007-2010
Tokyo University of Pharmacy and Life Sciences
2007
Kyushu Dental University
2005
Osaka University
1992
Tokyo Teishin Hospital
1982
Abstract Asymmetric cell division (ACD) underlies the development of multicellular organisms. In animal ACD, site is determined by active spindle-positioning mechanisms. contrast, it considered that in plants prior to mitosis microtubule-actin belt known as preprophase band (PPB) and localization mitotic spindle typically static does not govern plane. However, some plant species, ACD occurs absence PPB. Here, we isolate a hypomorphic mutant conserved microtubule-associated protein TPX2 moss...
Summary To treat sleep bruxism ( SB ), symptomatic therapy using stabilisation splints SS ) is frequently used. However, their effects on psychological stress and quality have not yet been examined fully. The objective of this study was to clarify the use quality. subjects (11 men, 12 women) were healthy volunteers. A crossover design Sleep measurements performed for three consecutive days or longer without (baseline) with an palatal splint PS data final day evaluated. We measured masseter...
Manganese accumulation in neuronal cells may be enhanced by interleukin-6<italic>via</italic>the up-regulation of ZIP14 and the down-regulation ZnT10.
The reaction center-binding D1 protein of Photosystem II is oxidatively damaged by excessive visible light or moderate heat stress. metalloprotease FtsH has been suggested as responsible for the degradation protein. We have analyzed distribution and subunit structures in spinach thylakoids various membrane fractions derived from using clear native polyacrylamide gel electrophoresis Western blot analysis. was found not only stroma but also II-enriched grana membranes. Monomeric, dimeric,...
Abstract The precise control of cell growth and proliferation underpins the development plants animals. These factors affect size organs body. In plants, cells are regulated by environmental stimuli intrinsic signaling, allowing different types to have specific characteristics. An increasing number that division been identified. However, mechanisms underlying type–specific characteristics in normal developmental context poorly understood. Here, we analyzed rice mutant osmo25a1, which is...
KCBP is a microtubule (MT) minus-end-directed kinesin widely conserved in plants. It was shown Arabidopsis that controls trichome cell shape by orchestrating MT and actin cytoskeletons using its tail motor domains. In contrast, the knockout (KO) line moss Physcomitrella patens showed defect nuclear organelle positioning apical stem cells. Moss postulated to transport nucleus chloroplast via direct binding their membranes, since it binds transports liposomes composed of phospholipids vitro....
Abstract Asymmetric cell division (ACD) underlies the development of multicellular organisms. It is considered that site in land plants predetermined prior to mitosis and localization mitotic spindle does not govern plane. This contrasts with animal ACD, which defined by active spindle-positioning mechanisms. Here, we isolated a hypomorphic mutant conserved microtubule-associated protein TPX2 moss Physcomitrium patens observed abnormal motility during division. defect compromised position...
Plant cells lack centrosomes and instead utilize acentrosomal microtubule organizing centers (MTOCs) to rapidly increase the number of microtubules at onset spindle assembly. Although several proteins required for MTOC formation have been identified, how is positioned right place not known. Here, we show that inner nuclear membrane protein SUN2 association with envelope (NE) during mitotic prophase in moss Physcomitrium patens. In actively dividing protonemal cells, accumulate around NE...
Abstract Kinesin-1, also known as conventional kinesin, is widely utilised for microtubule plus-end-directed (“anterograde”) transport of various cargos in animal cells. However, a motor functionally equivalent to the kinesin has not been identified plants, which lack kinesin-1 genes. Here, we show that plant-specific armadillo repeat-containing (ARK) long sought-after versatile anterograde transporter plants. In ARK mutants moss Physcomitrium patens , motility nuclei, chloroplasts,...
歯の喪失に至る歯周病や齲蝕は,口腔内微生物によって形成されるプラークに起因している.健全な口腔内環境を維持するには,患者の意識改革を得た上でプラークコントロールが継続されることが必要であり,そのためには歯科医師のみならず歯科衛生士の役割が重要となる.しかしながら,良好なプラークコントロールを得るたあに歯科衛生士による口腔衛生指導がどの程度必要なのか,また目標とした口腔衛生状態が得られた後の管理期間に良好な状態がどの程度持続し,またどの程度の間隔で歯科衛生士による衛生指導が必要かなど,口腔衛生指導における達成目標や時間を意識した報告は少ない.近年,歯科領域において医療の質を評価・改善するシステムであるクリティカルパスが導入されつつある.適切なクリティカルパスが導入されることにより,医療の標準化,患者へのインフォームド・コンセントの改善などが期待される.今回,歯科衛生士による口腔衛生指導用クリティカルパス作成を目的として,本学附属病院保存治療科を受診した患者を対象に,歯科衛生士によるブラッシング指導の回数とプラーク・コントロール・レコード(PCR)の変化との関係について検討した.患者...
The terminal position of mastication (centricocclusion: CO) has been reported to coincide with the intercuspal (ICP), which is defined as mandibular where maximum intercuspation occurs. However, relationship between ICP and CO still remains unclear.The purpose this study investigate CO.Recording analysis three-dimensional were performed in fourty subjects normal occlusion, fifty abnormal sixty craniomandibular disorders by using Sirognathograph Analyzing System.As a result, non-coincidence...
Abstract Plant cells lack centrosomes and instead utilise acentrosomal microtubule organising centres (MTOCs) to rapidly increase the number of microtubules at onset spindle assembly. Although several proteins required for MTOC formation have been identified, how is positioned right place not known. Here, we show that inner nuclear membrane protein SUN2 association with envelope (NE) during mitotic prophase in moss Physcomitrium patens . In actively dividing protonemal cells, accumulate...
肝移植後C型肝炎に対するDirect Acting Antivirals（DAA）治療効果を検討した．Genotype1は29症例で，ダクラタスビル＋アスナプレビル（DCV＋ASV）5例，ソホスブビル＋レジパスビル（SOF＋LDV）25例（含DCV＋ASV無効1例），Genotype2が2症例でSOF＋リバビリン治療を行った．DCV＋ASVは5例中4例で治療完遂，3例でSustained viral response（SVR）24を達成．SOF＋LDVは全例SVR24を達成．移植後2カ月以内の肝炎再燃例も含まれているが問題なく治療完遂可能であった．Genotype2はSVR24を達成．SOF中心レジメンで100％のSVR24達成率であり，移植後早期においても問題なくウイルス駆除達成可能であった．C型肝硬変の肝移植適応評価においてC型肝炎のネガティブインパクトはなくなったと言っても過言ではない．
KCBP is a microtubule (MT) minus-end-directed kinesin widely conserved in plants. It was shown Arabidopsis that controls trichome cell shape by orchestrating MT and actin cytoskeletons using its tail motor domains. In contrast, the knockout (KO) line moss Physcomitrella patens showed defect nuclear organelle positioning apical stem cells. Moss postulated to transport nucleus chloroplast via direct binding their membranes, since it binds transports liposomes composed of phospholipids vitro ....
コルチコステロイド含有軟膏(「ス」軟)7製品, コルチコステロイド含有クリーム(「ス」クリーム)9製品, コルチコステロイド含有ゲル(「ス」ゲル)3製品, 非ステロイド抗炎症剤含有軟膏(非「ス」軟)2製品, 非ステロイド抗炎症剤含有クリーム(非「ス」クリーム)2製品の合計23製品, およびホリスタースティア, トリイアレルゲンのうちから外用剤に配合されている可能性の高いアレルゲン27種と基剤2種を114例の皮膚疾患患者にclosed patch testを施行した。Closed testの結果製品の(+)以上(本邦基準)陽性率は48時間判定, 72時間判定の順に, 「ス」軟1.5%, 0.8%, 「ス」クリーム1.8%, 2.0%, 「ス」ゲル9.2%, 15.1%, 非「ス」軟6.2%, 5.4%, 非「ス」クリーム6.6%, 10.6%あつた。アレルゲンの陽性率(ICDRG基準)は上位5位まで, ネオマイシン13.8%, アクリノール5.4%, レゾルシン3.4%, ラノリンアルコール3.3%, P. G. 3.3%, ホルマリン3.3%, メントール3.3%であつた。