A5040481919- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Genomics and Phylogenetic Studies
- Mycorrhizal Fungi and Plant Interactions
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Mycobacterium research and diagnosis
- Carbohydrate Chemistry and Synthesis
- Microbial Metabolism and Applications
- Biocrusts and Microbial Ecology
- Protein Structure and Dynamics
- Forest Ecology and Biodiversity Studies
- Microbial Community Ecology and Physiology
- Fungal and yeast genetics research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Algal biology and biofuel production
- Plant biochemistry and biosynthesis
University of Illinois Chicago
2018-2019
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2011-2016
Friedrich Schiller University Jena
2011-2016
Schiller International University
2015
Summary Ectomycorrhizal fungi are thought to have a key role in mobilizing organic nitrogen that is trapped soil matter ( SOM ). However, the extent which ectomycorrhizal decompose and mechanism by they do so remain unclear, considering lost many genes encoding lignocellulose‐degrading enzymes present their saprotrophic ancestors. Spectroscopic analyses transcriptome profiling were used examine mechanisms five species of fungi, representing at least four origins symbiosis, extracted from...
Tuberculosis is an infectious disease of global concern. Members the diazaquinomycin (DAQ) class natural products have shown potent and selective activity against drug-resistant Mycobacterium tuberculosis. However, poor solubility has prevented further development this compound class. Understanding DAQ biosynthesis may provide a viable route for generation derivatives with improved properties. We sequenced genomes two actinomycete bacteria that produce distinct derivatives. While software...
Actinomycete bacteria isolated from freshwater environments are an unexplored source of natural products. Here we report the complete genome Great Lakes-derived Micromonospora sp. strain B006, revealing its potential for product biosynthesis. The 7-megabase pair chromosome B006 was sequenced using Illumina and Oxford Nanopore technologies followed by Sanger sequencing to close remaining gaps. All identified biosynthetic gene clusters (BGCs) were manually curated. Five known BGCs encoding...
Cyanobactins are a large family of cyanobacterial ribosomally synthesized and post-translationally modified peptides (RiPPs) often associated with biological activities, such as cytotoxicity, antiviral, antimalarial activities. They traditionally described cyclic molecules containing heterocyclized amino acids. However, this definition has been recently challenged by the discovery short, linear cyanobactins three to five acids well no residues. Herein we report scytodecamide (1) from...
We report the 9.7-Mb genome sequence of Streptomyces sp. strain F001, isolated from a marine sediment sample Raja Ampat, Indonesia. F001 produces diazaquinomycins, which exhibit potent and selective antituberculosis activity. In addition, it is also known to produce akashin A, blue pigment that has shown cytotoxic
Genome mining provides exciting opportunities for the discovery of natural products.However, in contrast to traditional bioassay-guided approaches, challenges genome include poor or no expression biosynthetic gene clusters (BGCs).Additionally, given that thousands BGCs are now available through extensive sequencing, how does one select discovery?Synthetic biology techniques can be used BGC refactoring and activation, whereas resistancegene-directed is a promising approach discover bioactive...