Fabricated microscale tissues that replicate in vivo architectures have shown huge potential regenerative medicine and drug discovery. Owing to the spatial organization of cell-encapsulated hydrogel microstructures, three-dimensional (3D) tissue structures been broadly applied as novel pathological or pharmacological models. However, reorganization arbitrary microstructures with tissue-specific shapes into 3D vitro microtissues mimic physiological morphology nutrient diffusion native...

Three-dimensional (3D) tissue models replicating liver architectures and functions are increasingly being needed for regenerative medicine. However, traditional studies focused on establishing 2D environments hepatocytes culture since it is challenging to recreate biodegradable 3D tissue-like architecture at a micro scale by using hydrogels. In this paper, we utilized gelatin methacryloyl (GelMA) hydrogel as matrix construct lobule-like microtissues co-culture of fibroblasts. GelMA with high...

The in vitro reproduction of three-dimensional (3D) cellular constructs to physiologically mimic human liver is highly desired for drug screening and clinical research. However, the fabrication a liver-mimetic 3D model using traditional bottom-up technologies challenging owing complex architecture specific functions real tissue. This work proposes versatile strategy spatially assembling gear-like microstructures encapsulating multiple cell types, reorganizing them into lobule-like...

Demodulation of fiber optic Fabry-Pérot (F-P) acoustic sensors with high sensitivity and a large dynamic range continues to pose significant challenges. In this paper, we propose an advanced phase-generated carrier (PGC) demodulation algorithm, applied innovatively membrane-free F-P operating under sound pressure. The algorithm optimizes results by adjusting the mixing phase delay, achieving best signal noise distortion ratio (SINAD) total harmonic (THD) (<1%). Additionally, introducing...

Ultrasonic measurement techniques are increasingly used to measure the burning rates of solid rocket fuel, but challenges arise due noise and signal attenuation caused by motor’s multi-layered structure. This paper proposes an adaptive thresholding method combined with a wavelet threshold function for effective ultrasonic denoising. Additionally, extreme value feature fitting algorithm is introduced accurate echo localization, even in low signal-to-noise ratio (SNR) conditions. Numerical...

Wind energy as a renewable source is easily available and widely distributed in cities. However, current wind-energy harvesters are inadequate at capturing from low-speed winds urban areas, thereby limiting their application self-powered sensor networks. A triboelectric-electromagnetic hybrid harvester with low startup wind speed (LSWS-TEH) proposed that also provides output power within wide range of speeds. An engineering-implementable propeller design method developed to reduce the...

A capacitive micromachined ultrasonic transducer structure for use in underwater imaging is designed, fabricated and tested this paper. In structure, a silicon dioxide insulation layer inserted between the top electrodes vibration membrane to prevent ohmic contact. The capacitance-voltage (C-V) characteristic curve shows that offers suitable levels of hysteresis repeatability performance. -6 dB center frequency 540 kHz has bandwidth 840 relative 155%. Underwater pressure 143.43 Pa achieved 1...

Designed microtissues that replicate highly ordered three-dimensional (3D) multicellular in vivo structures have shown huge potential biomedical research and drug discovery. Through microencapsulation microfluidic techniques, cell-laden microcapsules been widely used as pathological or pharmacological models. However, most conventional microtissue construction strategies can only engineer simply predefined with monotonous biological components two dimensions. Here, we propose a flexible 3D...

Magnetic microrobots have been developed for various biomedical applications, such as microswimmers indirect manipulation and assembly of objects. When non-magnetic targets fall or adhere to the substrate by gravity, is required move objects on surface. Inspired human walking, a novel magnetic microrobot with two pseudopods was designed. Driven periodic field, structure can subtly lift feet alternately walk forward. The amplitude frequency oscillation were optimized controllability system...

In vitro three-dimensional (3D) cellular models with native tissue-like architectures and functions have potential as alternatives to human tissues in regenerative medicine drug discovery. However, it is difficult replicate liver constructs that mimic vivo microenvironments using current approaches tissue engineering because of the vessel-embedded 3D structure complex cell distribution liver. This paper reports a pulsed microflow-based on-chip assembly method construct lobule-like spatial...

With the development of society and advancement technology, emergence Internet Things (IoT) has changed people's lifestyles raised demand for energy to a new level. However, there are some drawbacks in terms supply IoT sensors, such as limited battery capacity limitations replacement maintenance. Therefore, it become urgent develop sustainable green source (wind energy) using surrounding environment. Meanwhile, triboelectric nanogenerators (TENGs) with advantages flexible structure, low...

Purpose – The purpose of this paper was to develop a novel capacitive micromachined ultrasonic transducer (CMUT) reception and transmission linear array for underwater imaging at 400 kHz. Compared with traditional CMUTs, the developed offers higher electromechanical coupling coefficient directivity performance. Design/methodology/approach configuration newly CMUT determined by authors’ previous research into new element structures patterned top electrodes simulation analysis. Using...

With the increase of urbanization in modern society, road safety has become a pivotal issue smart cities. The development monitoring is concentrated on innovation and progress sensors. Here, an all-in-one customizable pressure–velocity sensor (PVS) developed for simultaneous traffic flow vehicle velocity. inclined dielectric-electrode middle layer with gradient structure grid electrode designed to eliminate errors caused by data fluctuations improve sensitivity reliability simultaneously....

Magnetic micromachines as wireless end-effectors have been widely applied for drug discovery and regenerative medicine. Yet, the magnetic assembly of arbitrarily shaped cellular microstructures with high efficiency flexibility still remains a big challenge. Here, novel clamp-shape micromachine using nanoparticles was developed indirect untethered bioassembly. With multi-layer template, nickel were mixed polydimethylsiloxane (PDMS) mold replication high-resolution permeability. To actuate...

Engineered microstructures that mimic in vivo tissues have demonstrated great potential for applications regenerative medicine, drug screening, and cell behavior exploration. However, current methods engineering the multi-extracellular matrix multicellular features of natural to realize tissue-mimicking vitro remain insufficient. Here, we propose a versatile method constructing heterogeneous by orderly integration macroscopic hydrogel exchange, microscopic manipulation, encapsulation...