A5076746872- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Metastasis and carcinoma case studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Connective Tissue Growth Factor Research
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Endometrial and Cervical Cancer Treatments
- Inflammasome and immune disorders
- Nutrition and Health in Aging
- Parkinson's Disease and Spinal Disorders
- CAR-T cell therapy research
- Inflammatory Myopathies and Dermatomyositis
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
University of Pittsburgh
2021-2024
UPMC Hillman Cancer Center
2024
University of Pittsburgh Medical Center
2020-2023
Baylor College of Medicine
2020
Duke University
2020
Duke University Hospital
2016
Duke Medical Center
2016
The University of Texas at Austin
2014
Systemic sclerosis (SSc) is a fibrotic and autoimmune disease characterized clinically by skin internal organ fibrosis vascular damage, serologically the presence of circulating autoantibodies. Although etiopathogenesis not yet well understood, results numerous genetic association studies support contributions as an important factor to SSc. In this paper, major genes SSc are reviewed. The most recent genome-wide (GWAS) taken into account along with robust candidate gene studies. literature...
The AP-1 factor basic leucine zipper transcription factor, ATF-like (BATF) is important for CD4+ Th17, Th9, and follicular Th cell development. However, its precise role in Th2 differentiation function remains unclear, the requirement BATF nonallergic settings of type-2 immunity has not been explored. In this article, we show that, response to parasitic helminths, Batf-/- mice are unable generate cells. As a consequence, they fail establish productive during primary secondary infection. T...
Background: Metabolic syndrome has previously been linked to increased risk of endometrial cancer. This study examines the association between metabolic and cancer-specific survival (CSS) in early stage locoregionally advanced Methods: The SEER-Medicare database was used identify a cohort patients with cancer 1992 2011 who underwent hysterectomy. Patients incomplete or grade information were excluded. stratified into (stage I II) III IVa) disease. status determined through Medicare claims 1...
Abstract The influence of sex and body mass index (BMI) on the efficacy immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) patients remains unclear. We conducted a retrospective study to evaluate relationship between sex, BMI, pretreatment weight loss (PWL), clinical outcomes 399 stage IV NSCLC treated with ICIs using data abstracted from medical records. Multivariable Cox proportional hazards models were used assess impact overall survival progression-free...
9540 Background: The majority of unresectable melanoma patients eventually progress on first-line checkpoint blockade therapy. Duvelisib is a potent phosphoinositide 3-kinase (PI3K) δ and γ isoform inhibitor approved for relapsed/refractory CLL. PI3Kγ inhibition has been shown to restore anti-PD1 activity in preclinical tumor models through conversion associated macrophages (TAMs) from an immunosuppressive pro-inflammatory state. PI3Kδ inactivation with impaired T regulatory cell (Treg)...
Abstract Lung cancer has the highest incidence of metastases to brain, with up 40% non-small cell lung (NSCLC) patients developing brain (BM). There is a critical need develop novel treatments effectively prevent and treat NSCLC BM. MET receptor tyrosine kinase that upon binding hepatocyte growth factor (HGF), mediates proliferation, epithelial-mesenchymal transition (EMT), invasion, angiogenesis metastasis. Recent studies have suggested pathway may be significant determinant metastatic...
Abstract Proteasome associated autoinflammatory syndromes (PRAAS) represent a rare class of early-onset diseases, including chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE syndrome). CANDLE is an inherited autosomal recessive disease recurrent fevers, skin lesions, other comorbidities. Point mutations in the proteasome subunit beta type-8 (psmb8) gene, which encodes beta-5i (ß5i) catalytic 20S immunoproteasome, have been linked to CANDLE. The...
e21085 Background: Recent studies suggest that among non-small cell lung cancer (NSCLC) patients treated with immunotherapy (IT), those who are male and/or have higher body mass index (BMI) benefit most; however, the role of other factors such as pretreatment weight loss is not clear. We conducted a retrospective study to further characterize relationship between sex, BMI and response IT in NSCLC. Methods: Patients stage IV NSCLC 2017 2019 at UPMC Hillman Cancer Center were included....
Myasthenia gravis associated with concurrent inflammatory myopathy is a rare but well-described syndrome, most often seen in patients thymoma. We present case of biopsy-proven granulomatous myositis positive acetylcholine receptor binding, blocking, and modulating antistriated antibodies, without clear clinical symptoms myasthenia the absence In addition, we include rarely reported neuromuscular ultrasound findings patient sarcoidosis. Inflammatory may precede development myopathy, it...