A5089781833- Digital Imaging in Medicine
- Hidradenitis Suppurativa and Treatments
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Social Media in Health Education
- Microscopic Colitis
- Chemotherapy-related skin toxicity
- Telemedicine and Telehealth Implementation
- Inflammasome and immune disorders
- Inflammatory Myopathies and Dermatomyositis
- Pharmaceutical industry and healthcare
- Dermatological and Skeletal Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Adverse Reactions
- Skin Diseases and Diabetes
- Herpesvirus Infections and Treatments
- Galectins and Cancer Biology
- Infrared Thermography in Medicine
- Wound Healing and Treatments
- Nonmelanoma Skin Cancer Studies
- Advanced Image Fusion Techniques
- Epigenetics and DNA Methylation
- Patient-Provider Communication in Healthcare
- Acne and Rosacea Treatments and Effects
- Genomics and Chromatin Dynamics
Duke University
2020-2024
Applied Genetic Technologies (United States)
2021
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle sweat gland density. These can present with purulent drainage scar formation. Dysregulation multiple immune pathways drives the complexity HS pathogenesis may account for heterogeneity treatment response patients. Using transcriptomic approaches, including single-cell sequencing protein analysis, we here characterize innate...
Patient-submitted images vary considerably in quality and usefulness. Studies that characterize patient-submitted a real-life setting are lacking.To evaluate the perceived usefulness of as determined by dermatologists agreement their responses.This survey study included patient submitted to Department Dermatology at Duke University (Durham, North Carolina) between August 1, 2018, December 31, 2019. From total pool 1200 images, 10 evaluated 200 or 400 each, with every image being 3...
The image quality received for clinical evaluation is often suboptimal. goal to develop an analysis tool assess patient- and primary care physician–derived images using deep learning model. Dataset included from August 21, 2018 June 30, 2022 with 4 unique labels. VGG16 model was fine tuned input data, optimal threshold determined by Youden's index. Ordinal labels were transformed binary a majority vote because distinguishes between 2 categories (good vs bad). At of 0.587, area under the...
Journal Article Association between age at symptom onset and disease severity in older patients with hidradenitis suppurativa Get access Simon W Jiang, Jiang Department of Dermatology https://orcid.org/0000-0002-9509-9001 Search for other works by this author on: Oxford Academic Google Scholar Amy J Petty, Petty Jennifer L Jacobs, Jacobs Camille Robinson, Robinson Sravya M Bhatia, Bhatia Jeffery T Kwock, Kwock Beiyu Liu, Liu Biostatistics Bioinformatics, Duke University School Medicine,...
Abstract Noncoding regulatory elements control gene expression and govern all biological processes. Epigenomic profiling assays have identified millions of putative elements, but systematically determining the function each those remains a substantial challenge. Here we adapt CRISPR-dCas9-based epigenomic element screening (CERES) technology to screen >100,000 non-coding defined by open chromatin sites in human K562 leukemia cells for their role regulating essential cellular In an initial...
Calcinosis cutis is the deposition of calcium salts in skin and subcutaneous tissue, manifesting as variably shaped papules, nodules, plaques that can substantially impair quality life. The pathophysiology calcinosis involves dysregulation proinflammatory cytokines, leukocytes, other components innate immune system. In some conditions associated with cutis, elevated serum calcium, phosphate, vitamin D may also perturb immunity. mechanisms by which these lead to cutaneous calcification likely...
Patient-submitted images can be helpful for medical decision-making when requested by dermatologists. However, unsolicited photographs may burden dermatologists and have variable clinical usefulness. In this survey study, we characterized dermatologists’ views on patient across various practice settings.
Dermatomyositis is an inflammatory myopathy involving the skin that typically affects patients between 40-60 years of age and more likely to be diagnosed in women. Around 10-20% dermatomyositis cases present with subclinical or absent muscle involvement, termed "clinically amyopathic." Presence anti-transcription intermediary factor 1? (TIF1?) antibodies important indicator underlying malignancy. We a patient anti-TIF1? positive amyopathic associated bilateral breast cancer. The was safely...
<sec> <title>BACKGROUND</title> The quality of the images received for Teledermatology evaluation is often suboptimal, with up to 50% patients providing that are poorly lit, off-center, or blurry. To ensure a similar level care in-person consultations, high-quality essential. </sec> <title>OBJECTIVE</title> aim this project develop an image analysis (IQA) tool assess patient and primary physicians derived using deep learning model, leveraging multiple instance ordinal regression model...
Background The quality of the images received for teledermatology evaluation is often suboptimal, with up to 50% patients providing that are poorly lit, off-center, or blurry. To ensure a similar level care in-person consultations, high-quality essential. Objective aim this study develop an image analysis tool assess patient- and primary physician (PCP)–derived using deep learning model leveraging multiple instance ordinal regression predictions. Methods data set used was acquired from...
Abstract Proteasome associated autoinflammatory syndromes (PRAAS) represent a rare class of early-onset diseases, including chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE syndrome). CANDLE is an inherited autosomal recessive disease recurrent fevers, skin lesions, other comorbidities. Point mutations in the proteasome subunit beta type-8 (psmb8) gene, which encodes beta-5i (ß5i) catalytic 20S immunoproteasome, have been linked to CANDLE. The...
<sec> <title>BACKGROUND</title> Store-and-forward (SAF) teledermatology uses electronically stored information, including patient photographs and demographic for clinical decision-making asynchronous to the encounter. The integration of SAF into practice has been increasing in recent years, especially during COVID-19 pandemic. Despite this growth, data regarding outcomes are limited. A key distinction among current literature involves comparing quality utility images obtained by patients...