A5048227366- Microbial Natural Products and Biosynthesis
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Toxic Organic Pollutants Impact
- Bacterial Genetics and Biotechnology
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Biochemical and Molecular Research
- Microbial Metabolic Engineering and Bioproduction
- Psychedelics and Drug Studies
- Genomics and Phylogenetic Studies
- Genomics, phytochemicals, and oxidative stress
- Nitrogen and Sulfur Effects on Brassica
- Polyamine Metabolism and Applications
- Peptidase Inhibition and Analysis
- Enzyme Structure and Function
- Chemical synthesis and alkaloids
- RNA modifications and cancer
- Pesticide and Herbicide Environmental Studies
- Chemical Synthesis and Analysis
- Plant biochemistry and biosynthesis
- Microbial bioremediation and biosurfactants
- Biocrusts and Microbial Ecology
Technical University of Munich
2016-2021
Max Planck Computing and Data Facility
2020-2021
Ludwig-Maximilians-Universität München
2021
German Center for Infection Research
2021
Center for Integrated Protein Science Munich
2016-2019
Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing pandemic disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation our vector vaccine based on modified vaccinia virus Ankara (MVA) against Middle East (MERS-CoV), which causes an infection in humans similar to SARS COVID-19. Here, describe construction preclinical characterization of a recombinant MVA...
Serratia plymuthica WS3236 was selected for whole genome sequencing based on preliminary genetic and chemical screening indicating the presence of multiple natural product pathways. This led to identification a putative sodorifen biosynthetic gene cluster (BGC). The is volatile organic compound (VOC) with an unusual polymethylated hydrocarbon bicyclic structure (C16H26) produced by strains S. plymuthica. BGC encoding consists four genes, two which (sodA, sodB) are homologs genes enzymes...
The epipolythiodioxopiperazine (ETP) gliotoxin mediates toxicity via its reactive thiol groups and thereby contributes to virulence of the human pathogenic fungus Aspergillus fumigatus. Self-intoxication mold is prevented either by reversible oxidation reduced or irreversible conversion bis(methylthio)gliotoxin. latter produced S-methyltransferase TmtA attenuates ETP biosynthesis. Here, we report crystal structure in complex with S-(5′-adenosyl)-l-homocysteine. features one substrate...
The biosynthetic pathway to the ambigols A–C from <italic>Fischerella ambigua</italic> 108b has been identified, cloned, heterologously expressed and functionally studied, including in-depth analysis of biaryl coupling biochemistry<italic>in vivo</italic>and<italic>in vitro</italic>.
Abstract The severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing pandemic disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation our vector vaccine based on vaccinia virus MVA against Middle East (MERS-CoV), which causes an infection in humans similar to SARS COVID-19. Here, describe construction preclinical characterization of a recombinant expressing...
The cyanobacterium <italic>Fischerella ambigua</italic> is a natural producer of polychlorinated aromatic compounds, the ambigols A–E. Here insights into biosynthesis these products are revealed.
Die Antibiotika Penicillin, Vancomycin und Daptomycin sind prominente Beispiele für mikrobielle Peptide. Viele solcher Peptide werden nicht in Ribosomen synthetisiert, sondern von nichtribosomalen Peptidsynthetasen (NRPS).1) NRPS können sehr groß sein: Ein Beispiel ist die Kolossin-Synthetase Kol, als einzelnes Protein mit einer Molekülmasse zirka 1,81 MDa an Größe bakterieller heranreicht.2) Dem hohen metabolischen Aufwand, der Biosynthese verbunden ist, steht enorme chemische Strukturraum...