A5017715604- Estrogen and related hormone effects
- Carbohydrate Chemistry and Synthesis
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Nematode management and characterization studies
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Hemophilia Treatment and Research
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Thyroid Disorders and Treatments
- Ethics and bioethics in healthcare
- Chronic Myeloid Leukemia Treatments
- Plant Virus Research Studies
- Ethics in medical practice
- RNA and protein synthesis mechanisms
- Palliative and Oncologic Care
- Chromosomal and Genetic Variations
- Retinoids in leukemia and cellular processes
Inserm
2023-2025
Université de Montpellier
2023-2025
Centre National de la Recherche Scientifique
2023-2025
Centre de Biologie Structurale
2023-2025
Brazilian Center for Research in Energy and Materials
2019-2024
Brazilian Biosciences National Laboratory
2019-2024
Universidade Estadual de Campinas (UNICAMP)
2019
Universidade Estadual Paulista (Unesp)
2015-2019
Retinoic acid receptors (RARs) are ligand-dependent transcription factors essential for various biological processes, including embryogenesis, differentiation, and apoptosis. RARs function as heterodimers with retinoid X (RXRs) regulate gene expression via retinoic response elements (RAREs). Their transcriptional activity is modulated by coregulators, corepressors maintaining repression in the absence of ligand coactivators enabling upon binding. Structural studies reveal that DNA binding...
The TOPOVIL complex catalyzes the formation of DNA double strand breaks (DSB) that initiate meiotic homologous recombination, an essential step for chromosome segregation and genetic diversity during gamete production. is composed two subunits (SPO11 TOPOVIBL) evolutionarily related to archaeal TopoVI topoisomerase complex. SPO11 TopoVIA subunit orthologue carries DSB catalytic activity. TOPOVIBL shares homology with TopoVIB ATPase subunit. formation, but its molecular function remains...
The use of large-scale genomic analyses has resulted in an improvement transposable element sampling and a significant increase the number reported HTT (horizontal transfer elements) events by expanding sequences general specific families these elements particular, which were previously poorly sampled. In this study, we investigated occurrence group that, until recently, uncommon among records Drosophila - Jockey elements, members LINE (long interspersed nuclear element) order non-LTR...
Abstract The TOPOVIL complex catalyzes the formation of DNA double strand breaks (DSB) that initiate meiotic homologous recombination, an essential step for chromosome segregation and genetic diversity during gamete production. is composed two subunits (SPO11 TOPOVIBL) evolutionarily related to archaeal TopoVI topoisomerase complex. SPO11 TopoVIA subunit orthologue carries DSB catalytic activity. TOPOVIBL shares homology with TopoVIB ATPase subunit. formation, but its molecular function...
Abstract Cardiac function requires appropriate proteins in each chamber. Atria slow myosin to act as reservoirs, while ventricles demand fast for swift pumping. Myosins are thus under chamber-biased cis -regulation, with gene expression imbalances leading congenital heart dysfunction. To identify regulatory inputs cardiac expression, we computationally and molecularly dissected the quail Slow Myosin Heavy Chain III ( SMyHC ) promoter that drives preferential atria. We show states...