A5065831014- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Reproductive Health and Contraception
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Trophoblastic Disease Studies
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Nitric Oxide and Endothelin Effects
- Growth Hormone and Insulin-like Growth Factors
- Blood Coagulation and Thrombosis Mechanisms
- Biomarkers in Disease Mechanisms
- Genetic Syndromes and Imprinting
- Public Health and Environmental Issues
- Pluripotent Stem Cells Research
Xiangya Hospital Central South University
2018-2025
Central South University
2017-2025
Hunan Provincial Center for Disease Control and Prevention
2024-2025
Taipei Veterans General Hospital
2024
Second Xiangya Hospital of Central South University
2017-2020
Hangzhou Women’s Hospital
2020
Intrauterine adhesion and cesarean scar diverticulum are the main complications of poor healing after uterine injury. Human umbilical cord MSCs transplantation has been regarded as most potential treatment in clinic, safety efficacy which however, remains unclear.In this study, ten patients were enrolled: six with intrauterine four diverticulum. All injected human twice into uterus. Beside chest X-ray, ECG abdominal ultrasound, many laboratory tests including blood routine, liver renal...
Placenta increta is a serious complication of pregnancy that needs variety intraoperative hemostatic methods to stop bleeding. However, the efficacy different still not known. This study aimed evaluate in placenta increta. A total 187 patients underwent treatment at Xiangya Hospital Central South University from March 1, 2017 January 31, 2021 were included this retrospective study. Perioperative data with retrospectively analyzed. The distributed into two groups according hemostasis methods,...
Embryo implantation in a cesarean scar resulting pregnancy (CSP) is special form of ectopic pregnancy. The aim this article to present our clinical classification and therapeutic strategy for CSP assess the efficacy, safety, social benefits.We categorized as either risky or stable. Risky have high risk severe hemorrhage should be treated immediately, while stable patients neither obvious vaginal bleeding nor significantly elevated serum β-human chorionic gonadotrophin (β-hCG). According...
Abstract Objectives The decidua is a tissue that contacts both maternal and foetal components pivotal to labour onset due its location. Due the heterogeneity of decidual tissue, it challenging study role in peripartum period. Herein, we analysed transcriptomes at single‐cell resolution. Materials methods Single‐cell RNA sequencing was performed for 29 231 cells before after delivery characterize transcriptomes. Results Eight major cell types (including endothelial cells, fibroblasts)...
Abstract Background Acute fatty liver of pregnancy (AFLP) is an uncommon but potentially life-threatening complication. Lacking prognostic factors and models renders prediction outcomes difficult. This study aims to explore develop a model predict three-month mortality AFLP. Methods retrospective included 78 consecutive patients fulfilling both clinical laboratory criteria Swansea for diagnosis Univariate multivariate cox regression analyses were used identify predictive mortality....
Objective: To evaluate the use of tourniquet and forceps to reduce bleeding during surgical treatment severe placenta accreta spectrum (placenta increta percreta). Methods: A was used in lower part uterus spectrum. Severe classified into two types according relative position surgery: upper-tourniquet type, which entire above tourniquet, lower-tourniquet or all below tourniquet. The effects were retrospectively compared. We then added group achieve further reduction. Finally, prospectively...
Placentae from patients with preeclampsia have increased susceptibility to necroptosis and phosphoglycerate mutase 5 (PGAM5) plays a role in many necrosis pathways. We determined whether PGAM5 promotes of trophoblast cells the underlying mechanisms this study.The injury model was established by treating JEG3 hypoxia for 24 h. The functional measurements were assessed cell counting kit-8, propidium iodide (PI)/Annexin V staining, JC-1 staining firefly luciferase ATP assay. expression proteins...
Neuromedin B (NMB) and its receptor regulate labor onset by mediating inflammatory factors; however the underlying mechanisms remain poorly understood. The present study is aimed to investigate of NMB-induced cyclo-oxygenase 2 (COX-2) expression interleukin (IL)-6 generation in human primary myometrial cells. results indicated that NMB could increase phosphorylation nuclear factor κB (NF-κB) transcription p65 (p65) Jun proto-oncogene, activator protein 1 (AP-1) subunit (c-Jun), turn,...
Bilateral renal agenesis (BRA) is a lethal con genital anomaly caused by the failure of normal development both kidneys early in embryonic development. Oligohydramnios on fetal ultrasonography reveals BRA. Although exact causes are not clear, BRA associated with mutations many genes. However, molecular diagnostics do pick up clinical patients. Nephronectin (NPNT) may be candidate protein for widening diagnosis. It essential kidney development, and knockout Npnt mice frequently leads to or...
Abstract Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F 2α agonist for the F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However, off-target activation closely related such as E subtype EP3 (EP3 receptor) by carboprost results in side effects limits clinical application. Meanwhile, FP selective latanoprost not suitable PPH due its poor solubility fast clearance. Here, we present...
IntroductionWe evaluated the quality of published clinical practice guidelines on placenta accreta spectrum (PAS) disorders to provide reference for development high-quality PAS guidelines.MethodsChina National Knowledge Infrastructure (CNKI), Wan Fang, PubMed, Embase, Web Science, and Cochrane Library were systematically searched. Quality assessments conducted using appraisal research evaluation (AGREE) II framework Reporting Items Guidelines in Healthcare (RIGHT) checklist. Intraclass...
Cervical cerclage is an established procedure for treating cervical insufficiency; however, its efficacy in twin pregnancies remains uncertain. This study aimed to evaluate the effectiveness of transvaginal complicated by insufficiency. Data were retrospectively collected from 155 women with diagnosed Participants divided into two groups: group (n = 131) and non-cerclage 24). The was further subdivided emergency ultrasound-indicated subgroups detailed analysis. duration gestation found be...
Preterm birth (PTB) is the most important cause of neonatal morbidity and mortality next to congenital anomalies in developed world. NF-κB AP-1 were reported play an role parturition initiation. However, interaction relationship between 2 molecules labor initiation has not yet been reported.This study aimed investigate their intracellular translocation during human late pregnant myometrial cells (HLPMCs).Co-immunoprecipitation (Co-IP), Western blot analysis, immunohistochemistry (IHC),...
Intercellular communication in the decidua plays important roles relaying information between maternal and fetal systems maintenance of pregnancy transition to labor. To date, several studies have explored cell-cell communications during different periods pregnancy, but systematically decoding intercellular network, its internal cascades, their involvement labor are still lacking. In this study, we reconstructed a decidual network based on scRNA-seq peripartum via CellCall method. The...
Histone deacetylase 6 (HDAC6) is a unique cytoplasmic enzyme in the HDAC family. The HDAC6 has been shown to play important roles several biological processes. Meanwhile, it also an attractive therapeutic target for variety of diseases. However, mechanism function not fully understood yet, and still lacking highly specific targeted drugs. Here, we generated homozygous knockout human embryonic stem cell (hESC) line, WAe009-A-21 by CRISPR/Cas9-based gene editing method. line does express...
Background: The termination of pregnancy in patients with placenta accreta spectrum disorder (PASD) during the second trimester remains uncertain. In addition, interventional radiology techniques, such as arterial embolization and balloon placement, are potential options. We evaluated outcomes PASD effectiveness preoperative techniques.