The article presents the state-of-the-art of alternating physisorption oppositely charged polyelectrolytes, so-called "layer-by-layer" method or "electrostatic self-assembly" (ESA), for preparation thin polymer coatings. In comparison to other, more established self-organization techniques, this recent is distinguished by its simplicity, versatility, and speed. particular, tendency self-healing unique. Emphasis given role molecular structure nature support. Also, various parameters...

Micellar complexes of human apolipoprotein A-I and phosphatidylcholine, with or without cholesterol, were prepared by adding (apo A-I) to sodium cholate-lipid mixtures. Cholate was removed dialysis the apo A-I.lipid isolated gel filtration chromatography density gradient ultracentrifugation. The lipid mixtures consisted dipalmitoylphosphatidylcholine egg yolk phosphatidylcholine in presence various molar ratios cholesterol. formation examined at different (PC)-to-apo ratios, PC-to-cholate...

Although most treatment research on bipolar disorder has focused mania, depressive episodes occur more frequently among patients with disorder. Here, we report the results of 2 identically designed, 8-week, multicenter, randomized, double-blind, placebo-controlled studies (CN138-096 and CN138-146) to evaluate efficacy safety aripiprazole monotherapy in outpatients I experiencing a major episode without psychotic features. Patients were randomized placebo or (initiated at 10 mg/d, then...

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO2MA) and hydroxyl-terminated oligo(ethylene glycol) (HOEGMA). The amount of hydroxyl reactive groups incorporated into the was varied by changing composition monomer mixture. These coatings were subsequently functionalized a natural antibacterial peptide, magainin I, via an oriented chemical grafting groups, which maintains...

Abstract We prepared and isolated defined, reconstituted high density lipoprotein (r-HDL) particles containing apolipoprotein A-I (apoA-I), palmitoyloleoylphosphatidylcholine, cholesterol. The initial r-HDL were by the sodium cholate method, then part of preparation was depleted phospholipid exposure to LDL, resulting, stable species gel filtration. characterized in terms their size, alpha-helix content, conformation apoA-I as reported fluorescence properties tryptophan residues. Then...

Phenylboronic acids are known to form covalent complexes with polyol compounds such as glucose. A novel polyelectrolyte, containing phenylboronic acid a glucose-sensitive moiety, has been synthesized and used for the fabrication of hollow polyelectrolyte capsules using layer-by-layer technique. The response glucose was observed rather fast dissolution when brought into contact glucose-containing medium. These first able respond stimulus that can be provided by human body (i.e., an increase...

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTThermo-Responsive Polymer Brushes with Tunable Collapse Temperatures in Physiological RangeAlain M. Jonas, Karine Glinel, Ron Oren, Bernard Nysten, and Wilhelm T. S. HuckView Author Information Melville Laboratory for Synthesis; Department of Chemistry; University Cambridge; Lensfield Road, Cambridge CB2 1EW, U.K. Cite this: Macromolecules 2007, 40, 13, 4403–4405Publication Date (Web):May 24, 2007Publication...

We prepared a spherical reconstituted high density lipoprotein (rHDL) particle in pure form and compared it with its homogeneous discoidal rHDL precursors, terms of the structure stability apolipoprotein A-I (apoA-I) component, dynamics surface lipids, relative reactivity lecithin-cholesterol acyltransferase. The apoA-I-structure was examined particles by circular dichroism fluorescence spectroscopic methods, binding monoclonal antibodies specific for apoA-I epitopes. on assessed effects...

The composition of temperature-responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature ∼35 °C. chains are grafted by antibacterial magainin I peptide, whose activity tested at different temperatures against various bacteria. switch from bactericidal cell-repellent below and slightly above 35 °C, respectively, due the progressive vertical brush. Detailed facts importance specialist readers published as "Supporting Information". Such...

The influence of the charge density polyelectrolytes on growth polyelectrolyte multilayers via layer-by-layer self-assembly from pure aqueous solutions was studied. Multilayers were built strong polyanions, namely poly(styrenesulfonate) and an exfoliated synthetic hectorite, cationic copolymers diallyldimethylammonium chloride (DADMAC) with N-methyl-N-vinylformamide (NMVF) for which composition thus varied systematically. analysis system {cationic copolymer/poly(styrenesulfonate)} reveals...

Polymer crystallization is notoriously difficult to control. Here, we demonstrate that the orientation of polymer crystals can be fully controlled at nanoscale by using nanoimprint lithography (NIL) with molds bearing nanotrenches shape thin films poly(vinylidene fluoride). This unprecedented control due thermomechanical history experienced during embossing, shift nucleation mechanism from heterogeneous homogeneous in confined regions mold, and constraining fast growth axis along direction...

We report on the fabrication of planar surfaces bearing nanoscale chemical patterns, obtained by combining electron beam lithography and gas-phase silanation, offering an unprecedented range functionalities down to 20−25-nm feature size level. Compared previously reported methods, this method combines a number desirable features such as high resolution, large accessible functions, possibility pattern surfaces, potential for higher throughput. The formation from gas phase silane monolayers...

We report on the first successful example of preparation triblock copolymers via a cationic ring-opening polymerization procedure. A library 30 was prepared from 2-methyl-, 2-ethyl-, 2-nonyl-, and 2-phenyl-2-oxazoline in single-mode microwave reactor. The polymers exhibited narrow molecular weight distributions showed only minor deviations targeted monomer ratio 33:33:33. glass-transition temperature spanned range 50 to 100 °C depending incorporated monomers. micellization behavior...

The abbreviations used are: HDL, high density plasma lipoprotein; apo A-I, major protein component of HDL; E, apolipoprotein found in very low lipoproteins, nascent and certain abnormal HDLs; Dm, fluorescent dansyl (5-dimethylaminonaphtha-

Micellar, discoidal complexes of human apolipoproteins A-I, A-11, C-I, (2-11, C-111-1, and C-111-2 with egg phosphatidylcholine (egg-PC) cholesterol were prepared by the cholate dialysis method.The complexes, isolated gel filtration, had similar lipid protein contents weight, on average: 1.77:0.083: 1 .O, egg-PC/cholesteroI/apolipoprotein (w/ w).The diameters discs, visualized electron microscopy estimated ranged from 100 to 200 A. The a-helix content in was 60-72%, their fluorescence...

Microwave-assisted polymerization has been utilized to synthesize amphiphilic poly(2-ethyl-2-oxazoline-block-2-"soy alkyl"-2-oxazoline) diblock copolymers (PEtOx-PSoyOx). The block have used prepare aqueous spherical micelles consisting of a PEtOx corona and PSoyOx core, which further cross-linked by UV irradiation. morphology these shown reversibly change from spheres short rods referred as rice grains whenever the were transferred water into acetone, nonselective solvent for constituent...

We elucidate the sequence of events occurring during collapse transition thermoresponsive copolymer brushes based on poly(di(ethyleneglycol) methyl ether methacrylate) chains (PMEO2MA) grown by atom-transfer radical polymerization (ATRP). The bulk brush is followed quartz crystal microbalance measurements with dissipation monitoring (QCM-D), and its outer surface assessed measuring equilibrium water contact angles in captive bubble configuration. collapses over a broad temperature interval...

Superhydrophobic aluminum surfaces with excellent corrosion resistance were successfully prepared by electrospinning of a novel fluorinated diblock copolymer solution. Micro- and nanostructuration the coating was obtained which proved to be an easy cheap technology fabricate superhydrophobic coating. The is made poly(heptadecafluorodecylacrylate-co-acrylic acid) (PFDA-co-AA) random as first block polyacrylonitrile (PAN) second one. promotes hydrophobicity surface reducing tension, while its...