A5058555147- Studies on Chitinases and Chitosanases
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022-2023
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction therefore an important cure strategy. Some nonnucleoside reverse transcriptase inhibitors induce selective cytotoxicity in vitro require concentrations far exceeding approved dosages. Focusing on this secondary activity, we found bifunctional compounds with HIV-1–infected cell kill potency at clinically...
Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that lead to eradication of persistent viral reservoirs in people living with (PLWH) remains an outstanding challenge achieving cure. Utilizing a phenotypic screen, we identified novel chemical class capable killing infected peripheral blood mononuclear cells. Tool compounds ICeD-1 ICeD-2 ("inducer cell death-1 2"), optimized for potency...