Alexander T Phan

ORCID: 0000-0002-4104-2229
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About
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Research Areas
  • COVID-19 Clinical Research Studies
  • Myasthenia Gravis and Thymoma
  • Cardiac electrophysiology and arrhythmias
  • Pleural and Pulmonary Diseases
  • Sepsis Diagnosis and Treatment
  • Trauma Management and Diagnosis
  • Diabetes and associated disorders
  • Tracheal and airway disorders
  • Blood groups and transfusion
  • Cardiac tumors and thrombi
  • Nail Diseases and Treatments
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Long-Term Effects of COVID-19
  • Lymphoma Diagnosis and Treatment
  • Atrial Fibrillation Management and Outcomes
  • Respiratory Support and Mechanisms
  • Autoimmune Bullous Skin Diseases
  • Antibiotics Pharmacokinetics and Efficacy
  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Neurogenesis and neuroplasticity mechanisms
  • Streptococcal Infections and Treatments
  • Platelet Disorders and Treatments
  • Respiratory and Cough-Related Research
  • Pneumothorax, Barotrauma, Emphysema

Arrowhead Regional Medical Center
2021-2024

Penn Presbyterian Medical Center
2023

Northwell Health
2023

New York University
2023

Cornell University
2020-2023

Loma Linda University
2022-2023

Loma Linda University Medical Center
2022-2023

Kaiser Permanente Fontana Medical Center
2022

St. George's University
2021

Johns Hopkins Medicine
2015-2018

In a classic model of mammalian brain formation, precursors principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron tangentially. These migration modes have significant implications for function. Here we used clonal lineage tracing active glia-like neural stem cells in the adult mouse dentate gyrus and made surprising discovery that proliferating neuronal granule exhibit tangential blood vessels, followed by limited migration. Genetic...

10.1073/pnas.1508545112 article EN Proceedings of the National Academy of Sciences 2015-07-13

Infection by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is known to have the highest mortality rate among elderly and those with pre-existing medical conditions. Viral load has been directly correlated increased risk of in hospitalized patients. Once infected, symptoms first arise approximately six seven days later followed immunoglobulin M (IgM) antibodies appearing 8-12 after onset clinical symptoms. Recent studies noted that monoclonal antibody combination casirivimab...

10.7759/cureus.15280 article EN Cureus 2021-05-27

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6586 article EN 2024-04-30

Alexander T. Phan, Ari A. Ucar, Aldin Malkoc, Janie Hu, Luke Buxton, Alan W. Tseng, Fanglong Dong, Julie P.T. Nguyễn, Arnav P. Modi, Ojas Deshpande, Johnson Lay, Andrew Ku, Dotun Ogunyemi, Sarkis Arabian. Blood Res 2023;58:138-44. https://doi.org/10.5045/br.2023.2023122

10.5045/br.2023.2023122 article EN Blood Research 2023-09-27

Urinary tract stones are found in many locations, such as the kidney or ureter, and, less commonly, bladder. Bladder solid calculi that usually composed of calcified material, most commonly uric acid, and typically weigh than 100 g. There is a higher prevalence bladder males females, which can be explained by pathophysiology how these formed. Namely, tend to form secondary urinary stasis, setting benign prostatic hyperplasia (BPH). However, otherwise healthy individuals without anatomic...

10.7759/cureus.39718 article EN Cureus 2023-05-30

Histoplasmosis is caused by infection with Histoplasma capsulatum (H. capsulatum). Progressive disseminated histoplasmosis a more severe form of and seldom diagnosed in non-endemic regions the world owing to fungus's geographical distribution. In United States (USA), classically known be endemic Mississippi Ohio River valleys, cases areas, such as southwest USA, are exceedingly rare. Patients acquired immunodeficiency syndrome (AIDS) at risk for H. capsulatum, failure recognize treat may...

10.14740/jmc4097 article EN Journal of Medical Cases 2023-07-01

Rib plating is a recommended intervention for patients with multiple rib fractures or flail chest to improve shortness of breath, significantly reduce pain, and shorten the length hospital stay. Here, we report unique extremely rare finding in patient empyema following intrathoracic fixation. A 32-year-old male history alcohol use disorder presented emergency department trauma bay after motor vehicle accident. Computed tomography (CT) showed right hemopneumothorax fourth ninth displacement....

10.14740/jmc4267 article EN Journal of Medical Cases 2024-08-23

Introduction. Strongyloides stercoralis causes a helminthic infection that occurs via penetration of the skin with migration to bloodstream, tracheobronchial tree, and gastrointestinal system. Pulmonary manifestations are rare typically seen in immunosuppressed patients who have hyperinfection syndrome. Eosinophilic pleural effusions strongyloidiasis only cited few case reports. Case Presentation. A 45-year-old male past medical history diabetes mellitus, alcoholic cirrhosis, end-stage renal...

10.1155/2024/6652207 article EN cc-by Case Reports in Pulmonology 2024-04-08

Introduction: Veillonella parvula is a bacteria that can be found in normal oral and gastrointestinal flora. infection rare immunocompetent patients but known to cause periorbital cellulitis, endocarditis, osteomyelitis bacteremia; however, its association with acute respiratory distress syndrome (ARDS) has not been previously documented. Case presentation: A 36-year-old female no history who presented right-sided chest, flank upper abdominal pain after motor vehicle accident. Computed...

10.1097/ms9.0000000000002278 article EN Annals of Medicine and Surgery 2024-06-14

Mirtazapine, an alpha-2 adrenergic receptor, 5-hydroxytryptamine (5-HT)2, and 5-HT3 antagonist, is commonly used in patients for depression anorexia. Its mechanism disinhibits serotonin norepinephrine. Though typically a well-tolerated medication, rare adverse effect arrhythmia, including ventricular bigeminy. To date, no case report has cited normal dosing of mirtazapine as cause premature or atrial contractions. Only cases overdose have been associated with arrhythmias, QT prolongation...

10.14740/jmc4265 article EN Journal of Medical Cases 2024-11-11

Fluoroquinolones (FLQs) are commonly prescribed for infections in both the inpatient and outpatient setting. Though typically well-tolerated, FLQs have been associated with central nervous system adverse effects, especially older adults those who metabolize medications at suboptimal rates. Rarely, these drugs can cause serious neurotoxic manifestations, such as seizures, psychosis, or encephalopathy. Although new quinolone derivatives like levofloxacin most side we show that unwanted effects...

10.14740/jmc4264 article EN Journal of Medical Cases 2024-12-21

Sclerosing epithelioid fibrosarcoma is an aggressive sarcoma subtype with poor prognosis and limited response to conventional chemotherapy regimens. Diagnosis can be difficult owing its variable presentation, cases of sclerosing are rare. typically affects middle-aged individuals, studies inconsistently citing gender predominance. arises from the bones soft tissues often has local recurrence after resection late metastases. Immunohistochemical staining positive for mucin-4. Werner syndrome...

10.1186/s13256-023-04249-6 article EN cc-by Journal of Medical Case Reports 2023-12-17

Intracardiac bronchogenic cysts are extremely rare congenital anomalies that arise during foregut development when the embryologic heart tube and ventral in close proximity to one another. We report a case of an interatrial septal cyst found on non-contrast enhanced computed tomography (CT) 66-year-old female who presented emergency department with chest pain. Further cardiac investigations, including contrast-enhanced CT angiogram heart, transthoracic echocardiogram, transesophageal...

10.14740/cr1511 article EN Cardiology Research 2023-08-01

Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of non-Hodgkin lymphoma. Typical symptoms include cough, chest pain, and dyspnea; however, cardiac tamponade as the primary manifestation exceedingly rare. We hereby present case 34-year-old male with past medical history obesity, who presented to our emergency department chronic dry cough for 4 months. On admission, computed tomography demonstrated large 11.1-cm diameter anterior mass, echocardiography physiology. The patient...

10.14740/jmc4106 article EN Journal of Medical Cases 2023-08-01

COVID-19 pneumonia can cause a wide range of complications including pneumothorax and empyema. However, in severe cases, it lead to bronchopulmonary fistula (BPF) formation persistent air leak due connection between the pleural space bronchial tree. We report case 77-year-old man with history hypertension, who presented emergency department for evaluation dyspnea. Admission labs were significant positive rapid antigen SARS-Cov-2 test elevated troponin I. A chest x-ray demonstrated patchy...

10.7759/cureus.31686 article EN Cureus 2022-11-20
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