A5032988288- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Protein Degradation and Inhibitors
- Cannabis and Cannabinoid Research
- Esophageal Cancer Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Kruppel-like factors research
- Microbial Metabolites in Food Biotechnology
- Peroxisome Proliferator-Activated Receptors
- Colorectal Cancer Screening and Detection
- Metabolism, Diabetes, and Cancer
- Food composition and properties
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Genomics and Chromatin Dynamics
- bioluminescence and chemiluminescence research
- Computational Drug Discovery Methods
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Phenothiazines and Benzothiazines Synthesis and Activities
University of Rome Tor Vergata
2020-2025
MicroRNA (miR)-126 is frequently downregulated in malignancies, including breast cancer (BC). Despite its tumor-suppressive role, the mechanisms underlying miR-126 deregulation BC remain elusive. Through silencing experiments, we identified Early B Cell Factor 1 (EBF1), ETS Proto-Oncogene 2 (ETS2), and Krüppel-Like (KLF2) as pivotal regulators of expression. These transcription factors were found to be due epigenetic or a “poised but not transcribed” promoter state, impairing Gene Ontology...
Several phytochemical-containing herbal extracts are increasingly marketed as health-promoting products. In particular, chamomile (Matricaria recutita L.) is well known for its anti-inflammatory, analgesic, and antitumor properties. Here, we evaluated differences in chemical composition among six commercially available products their potential impact on biological activity human immortalized colonocytes. Our investigation encompassed: (i) preparation of dry yield evaluation; (ii) qualitative...
Among the surrounding cells influencing tumor biology, platelets are recognized as novel players they release microvesicles (MVs) that, once delivered to cancer cells, modulate signaling pathways related cell growth and dissemination. We have previously shown that physiological delivery of platelet MVs enriched in miR-126 exerted anti-tumor effects different breast (BC) lines. Here, we seek further insight by identifying AKT2 kinase a miR-126-3p direct target, assessed bioinformatic analysis...
Wholegrain wheat flours are in great demand from consumers worldwide because they considered healthier then refined flours. They can be obtained by either stone milling, which is experiencing a revival Europe, or roller milling. In order to study compositional differences due the milling technology and explore possibility of better qualification wholegrain means nutritionally oriented quality parameters, eight mixes soft grains were milled products analyzed for their protein, ash, lipids,...