A5003335216- Vitamin C and Antioxidants Research
- Cannabis and Cannabinoid Research
- Skin Protection and Aging
- Cancer-related Molecular Pathways
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Cell death mechanisms and regulation
- Antioxidant Activity and Oxidative Stress
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Exercise and Physiological Responses
- Redox biology and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HIV Research and Treatment
- Iron Metabolism and Disorders
- bioluminescence and chemiluminescence research
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Blood properties and coagulation
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Sleep and Wakefulness Research
University of Rome Tor Vergata
2015-2025
Ospedali Riuniti di Ancona
2016
Istituti di Ricovero e Cura a Carattere Scientifico
1994-2005
Universidade Federal de São Paulo
2003-2004
Sapienza University of Rome
2004
Laboratoire de Biochimie
2000
Weatherford College
2000
Istituto Dermopatico dell'Immacolata
1997-1998
Università Cattolica del Sacro Cuore
1994
Vanderbilt University
1994
MicroRNA (miR)-126 is frequently downregulated in malignancies, including breast cancer (BC). Despite its tumor-suppressive role, the mechanisms underlying miR-126 deregulation BC remain elusive. Through silencing experiments, we identified Early B Cell Factor 1 (EBF1), ETS Proto-Oncogene 2 (ETS2), and Krüppel-Like (KLF2) as pivotal regulators of expression. These transcription factors were found to be due epigenetic or a “poised but not transcribed” promoter state, impairing Gene Ontology...
Abstract: To infect target cells, the human immunodeficiency virus (HIV) type I (HIV‐1) must engage not only well‐known CD4 molecule, but it also requires one of several recently described coreceptors. In particular, CXCR4 (LESTR/fusin) receptor allows fusion and entry T‐tropic strains HIV, whereas CCR5 is major coreceptor used by primary HIV‐1 that macrophages + T‐helper cells (M‐tropic viruses). addition, α chemokine SDF1α β chemokines MIP1α, MIP1β, RANTES, natural ligands CCR5,...
Several phytochemical-containing herbal extracts are increasingly marketed as health-promoting products. In particular, chamomile (Matricaria recutita L.) is well known for its anti-inflammatory, analgesic, and antitumor properties. Here, we evaluated differences in chemical composition among six commercially available products their potential impact on biological activity human immortalized colonocytes. Our investigation encompassed: (i) preparation of dry yield evaluation; (ii) qualitative...
Among the surrounding cells influencing tumor biology, platelets are recognized as novel players they release microvesicles (MVs) that, once delivered to cancer cells, modulate signaling pathways related cell growth and dissemination. We have previously shown that physiological delivery of platelet MVs enriched in miR-126 exerted anti-tumor effects different breast (BC) lines. Here, we seek further insight by identifying AKT2 kinase a miR-126-3p direct target, assessed bioinformatic analysis...