A5020511843- vaccines and immunoinformatics approaches
- Poxvirus research and outbreaks
- Transgenic Plants and Applications
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Microbial Natural Products and Biosynthesis
- Bacteriophages and microbial interactions
- Influenza Virus Research Studies
- Microbial Metabolism and Applications
- Malaria Research and Control
- Bacterial Genetics and Biotechnology
- Enzyme function and inhibition
- Cervical Cancer and HPV Research
- Viral Infectious Diseases and Gene Expression in Insects
- Vaccine Coverage and Hesitancy
- Biotin and Related Studies
- Genetic Associations and Epidemiology
- Herpesvirus Infections and Treatments
- Face and Expression Recognition
- IoT and Edge/Fog Computing
- SARS-CoV-2 and COVID-19 Research
- Face recognition and analysis
- Mosquito-borne diseases and control
Beijing University of Technology
2019-2024
Abdul Wali Khan University Mardan
2017-2023
The emerging monkeypox virus (MPXV) is a zoonotic orthopoxvirus that causes infections in humans similar to smallpox. Since May 2022, cases of (MPX) have been increasingly reported by the World Health Organization (WHO) worldwide. Currently, there are no clinically validated treatments for MPX infections. In this study, an immunoinformatics approach was used identify potential vaccine targets against MPXV. A total 190 MPXV-2022 proteins were retrieved from ViPR database and subjected various...
Leishmania tropica is a vector-borne parasitic protozoa that the leading cause of leishmaniasis throughout global tropics and subtropics. L. multidrug-resistant parasite with diverse set serological, biochemical, genomic features. There are currently no particular vaccines available to combat leishmaniasis. The present study prioritized potential vaccine candidate proteins using subtractive proteomics vaccinomics approaches. These were downstream analyzed predict B- T-cell epitopes based on...
Lumpy skin disease is a fatal emerging of cattle, which has started to gain extensive attention due its rapid incursions across the globe. The epidemic causes economic loss and cattle morbidity. Currently, there are no specific treatments safe vaccines against lumpy virus (LSDV) halt spread disease. current study uses genome-scan vaccinomics analyses prioritize promiscuous vaccine candidate proteins LSDV. These were subjected top-ranked B- T-cell epitope prediction based on their...
Monkeypox virus (MPXV) is an orthopoxvirus, causing zoonotic infections in humans with smallpox-like symptoms. The WHO reported MPXV cases May 2022 and the outbreak caused significant morbidity threats to immunocompromised individuals children. Currently, no clinically validated therapies are available against infections. present study based on immunoinformatics approaches design mRNA-based novel vaccine models MPXV. Three proteins were prioritized high antigenicity, low allergenicity,...
Shigella sonnei is a gram-negative bacterium and the primary cause of shigellosis in advanced countries. An exceptional rise prevalence disease has been reported Asia, Middle East, Latin America. To date, no preventive vaccine available against S . infections. This pathogen shown resistances towards both first- second-line antibiotics. Therefore, an effective broad spectrum development indispensable. In present study, vaccinomics-aided immunoinformatics strategies were pursued to identify...
Abstract Human papilloma virus (HPV) is a serious threat to human life globally with over 100 genotypes including cancer causing high risk HPVs. Study on protein interaction maps of pathogens their host recent trend in ‘omics’ era and has been practiced by researchers find novel drug targets. In current study, we construct an integrated map HPV its Cytoscape analyze it further using various bioinformatics tools. We found out 2988 interactions between 12 2061 proteins among which identified...
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry autoreactive T cells to cross-activate. The aim of the current study was implement immunoinformatics approaches infer sequence- between human proteomic datasets. all so far known human-infecting viruses were obtained from VIPR database, complete proteome data retrieved NCBI repository. Based on a predefined, stringent...
Leishmania tropica is a tropical parasite causing cutaneous leishmaniasis (CL) in humans. Leishmaniasis serious public health threat, affecting an estimated 350 million people 98 countries. The global rise antileishmanial drug resistance has triggered the need to explore novel therapeutic strategies against this parasite. In present study, we utilized recently available multidrug resistant L. strain proteome data repository identify alternative targets based on comparative subtractive...
The gram negative bacteria species of Pseudomonas putida (P. putida) are important for heterologous expression diverse biosynthetic pathways and numerous secondary metabolites biosynthesis. genes code such proteins organized in microbial genomes as clusters to bring the concerted entire machinery. complete whole genome sequences more than fifty different strains available public DNA databases provide an excellent opportunity investigate genetically encoded potential ecologically P. strains....
Influenza A virus (IAV) infection is a serious public health problem not only in South East Asia but also European and African countries. Scientists are using network biology to dig deep into the essential host factors responsible for regulation of infections. Researchers can explore invasion cells by studying virus-host relationship based on their protein-protein interaction network. In this study, we present comprehensive IAV-host that obtained literature-curated protein datasets some...
Dengue Virus (DENV) is a serious threat to human life worldwide and one of the most dangerous vector-borne diseases, causing thousands deaths annually. We constructed comprehensive PPI map DENV with its host Homo sapiens performed various bioinformatics analyses. found 1195 interactions between 858 10 proteins. Pathway enrichment analysis was on two sets gene products, top 5 proteins maximum number dengue viral revealed noticeable results. The non-structural protein NS1 in had protein,...
Prevention of Clostridium difficile infection is challenging worldwide owing to its high morbidity and mortality rates. C . currently being classified as an urgent threat by the CDC. Devising a new therapeutic strategy become indispensable against due rates reinfection increasing antimicrobial resistance. The current study based on core proteome data identify promising vaccine drug candidates. Immunoinformatics vaccinomics approaches were employed construct multi-epitope-based chimeric...
The microbial genome sequences provide solid in silico framework for interpretation of their drug-like chemical scaffolds biosynthetic potentials. Pseudomonas fluorescens strains are metabolically versatile and producing therapeutically important natural products.The key objective the present study was to mine publically available data P. genomes putative metabolites identification.We implemented computational biology resources AntiSMASH BAGEL3 secondary prediction from sequences. predicted...