A5058166419- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Genetic diversity and population structure
- Liver physiology and pathology
- RNA and protein synthesis mechanisms
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Plant-Microbe Interactions and Immunity
- Machine Learning in Bioinformatics
- Herpesvirus Infections and Treatments
- Synthesis and biological activity
- Microbial Applications in Construction Materials
- Nanomaterials for catalytic reactions
- Natural Antidiabetic Agents Studies
- Mesenchymal stem cell research
- Fungal Biology and Applications
- Digital Imaging for Blood Diseases
- interferon and immune responses
- Forensic and Genetic Research
- Hepatitis Viruses Studies and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Blood groups and transfusion
- Brucella: diagnosis, epidemiology, treatment
Abdul Wali Khan University Mardan
2017-2025
University of Swat
2022
Pakistan Institute of Engineering and Applied Sciences
2017
Bridgeport Hospital
1991
The removal of toxic metals like lead (Pb) and cadmium (Cd) is very urgent keeping their hazardous effects in view. In this work, seeds Albizia lebbeck Melia azedarach trees were converted into activated carbon adsorbents applied for the adsorptive Pb Cd from an aqueous solution. as prepared characterised by Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM). efficiencies both strongly dependent on initial concentration, contact time, pH, temperature quantity...
This study investigated the phytochemical characteristics and antioxidant activity in leaves, roots, stem, flower, seed parts of Datura alba (D. alba). The also assessed heavy metal (Cr, Mn, Zn, Cu) accumulation each part plant. Among phytochemicals, alkaloids were found only leaves while tannins, flavonoids, phenols present all For activity, free radical scavenging assay for 2,2-diphenyl-1-picrylhydrazyl (DPPH) was performed using ascorbic acid as standard. Higher shown by stem extract...
Pyrazinoic acid-resistant tuberculosis is a severe chronic disorder. First-line drugs specifically target the ribosomal protein subunit-1 (RpsA) and stop trans-translation in wild-type bacterium, causing bacterial cell death. In mutant strain, deletion of ala438 does not let pyrazinoic acid to bind active site RpsA ensures that bacterium survives. Hence, such cases require an immediate successful regime. The current study was designed identify inhibitors could state protein. Initially,...
Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that involved in inflammasome activation, and the aberrant expression of NLRP3 responsible for diabetes mellitus, its complications, many other inflammatory diseases. considered a promising drug target novel design. Here, pharmacophore model was generated from most potent inhibitor, validation performed by Gunner-Henry scoring method. The validated used to screen selected compounds databases. As result, 646 were mapped on...
The association between microbes and plant roots involves a complex chemical dialogue featured by IAA flavonoids in addition to other signals. Current study is focused on the role of as essential elements an endophytic fungus maize roots. strain was isolated from leaves Withania somnifera identified Aspergillus fumigatus greenish 18S rDNA sequence. Culture filtrate contained phyotstimulant (IAA, ammonia ACC) signaling compounds including IAA, flavonols. effectively colonized enhanced its...
Plasmodium falciparum is an obligate intracellular parasite of humans that causes malaria. Falciparum malaria a major public health threat to human life responsible for high mortality. Currently, the risk multi-drug resistance P. rapidly increasing. There need address new anti-malarial therapeutics strategies combat drug-resistance threat.The essential proteins were retrieved from recently published studies. These initially scanned against host and its gut microbiome proteome sets by...
Plant species represent the hierarchical expression of vegetation as it is affected by various environmental gradients. We explored plant composition, distribution pattern, communities formation and their respective indicators under influence factors in Dhirkot region, Azad Jammu Kashmir. It was hypothesized that different were responsible for each with a distinct indicator. Quantitative ecological techniques used sampling vegetation. A total 114 quadrats established 13 selected sites....
The hyperglycemic condition due to diabetes could be managed through retardation of the carbohydrate metabolism by inhibiting enzymes involved in its degradation. Currently available therapeutic drugs for as inhibitors α-glucosidase have limitations on safety, efficacy, and potency. Terpenes been traditionally used treatment different ailments humans. Pharmacological activities related types terpenes include antiviral, anticancer, antidepressant, anti-inflammatory, antidiabetic among others....
Carbamazepine (CBZ) is a widely used antiepileptic drug that shows resistance to removal by conventional water treatment technologies. This study reported novel combination of ultrafiltration (UF) and photocatalysis as photocatalytic membrane for CBZ removal. First, UF with surface-immobilized titanium dioxide nanoparticles (TiO2 NPs) was prepared using approach in our previous studies. The performed without UV light at flow rate 0.5 L/min under varying transmembrane pressure (TMP)...
The genomic miscellany of malaria parasites can help inform the intensity transmission and identify potential deficiencies in control programs. This study was aimed at investigating miscellany, allele frequencies, MOI P. falciparum infection.A total 85 confirmed isolates out 100 were included this that collected from patients aged 4 months to 60 years nine districts Khyber Pakhtunkhwa Province. Parasite DNA extracted 200µL whole blood samples using Qiagen extraction kit following...
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry autoreactive T cells to cross-activate. The aim of the current study was implement immunoinformatics approaches infer sequence- between human proteomic datasets. all so far known human-infecting viruses were obtained from VIPR database, complete proteome data retrieved NCBI repository. Based on a predefined, stringent...
Naswar, a smokeless tobacco product, commonly consumed in Pakistan, is associated with 10-fold increase the risk of oral cancer. However, little known about Naswar's underlying toxicity mechanisms.The current study aimed to investigate effects Naswar use on health and salivary parameters.A case-control was conducted among users (n=42) age-matched healthy controls Pakistan 2019. Participant data were collected using questionnaires. Decayed, missing, filled teeth (DMFT) scores computed during...
Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, activity can be restored inhibiting the interaction MDMX (2N0W) and MDM2 (4JGR) proteins with protein. Objective: current, study in silico approaches were adapted to use a natural product as source therapy. Methods: current For studies, Chemdraw Molecular Operating Environment used for structure drawing molecular docking, respectively. Flavonoids...
Plasmodium vivax variant interspersed repeats (vir) refer to the key protein used for escaping host immune system. Knowledge in genetic variation of vir genes can be development vaccines or diagnostic methods. Therefore, we evaluated diversity P. populations several Asian countries, including Pakistan, which is a malaria-endemic country experiencing significant rise malaria cases recent years. We analyzed and population structure 4 (vir 4, 12, 21, 27) Pakistan compared these features those...
Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a major candidate for the blood-stage malaria vaccine. Genetic polymorphisms of global pfama-1suggest that genetic diversity gene can disturb effective vaccine development targeting this antigen. This study was conducted to explore and structure pfama-1 among P. isolates collected in Khyber Pakhtunkhwa (KP) province Pakistan. A total 19 full-length sequences were obtained from KP-Pakistan isolates, polymorphism natural selection...