A5026402671- Shoulder Injury and Treatment
- Infectious Diseases and Tuberculosis
- Spine and Intervertebral Disc Pathology
- Peripheral Nerve Disorders
- Spinal Fractures and Fixation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma Management and Diagnosis
- Esophageal and GI Pathology
- Infective Endocarditis Diagnosis and Management
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Nerve Injury and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Autopsy Techniques and Outcomes
- Orthopedic Surgery and Rehabilitation
- Cardiac tumors and thrombi
- Shoulder and Clavicle Injuries
- Musculoskeletal Disorders and Rehabilitation
- Adrenal Hormones and Disorders
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Actinomycetales infections and treatment
- Academic integrity and plagiarism
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
University of Rochester Medical Center
2024-2025
Cleveland Clinic
2025
University of Rochester
2021-2025
University of Massachusetts Chan Medical School
2021-2024
Sohag University
2024
MedStar Washington Hospital Center
2024
Alexandria University
2023
Brigham and Women's Hospital
2023
Harvard University
2023
Rutgers, The State University of New Jersey
2023
Maternal immune activation (MIA) disrupts the central innate system during a critical neurodevelopmental period. Microglia are primary cells in brain although their direct influence on MIA phenotype is largely unknown. Here we show that alters microglial gene expression with upregulation of cellular protrusion/neuritogenic pathways, concurrently causing repetitive behavior, social deficits, and synaptic dysfunction to layer V intrinsically bursting pyramidal neurons prefrontal cortex mice....
Intercostal neuralgia can be debilitating and extremely difficult to treat despite multi-modal therapies. The literature describing the role of neuromodulation in patients with intercostal is scarce. In this medically challenging case report, we describe a 56-year-old male near complete resolution intractable chronic neuralgia, secondary traumatic rib fractures multiple surgical interventions, single lead thoracic spinal cord stimulator (SCS) implant. Neuromodulation therapies should...
Introduction Current treatment modalities of lumbar spinal stenosis range from conservative medical management and physical therapy to open surgical decompression. Minimally invasive decompression (MILD) Superion interspinous spacers (SISS) Vertiflex offer the promise effective pain relief with shorter recovery time lesser potential complications compared procedures general anesthesia. Despite their increasing utilization, complication profile is not well established in literature. Methods...
Study Design. Observational epidemiological study. Objective. To identify and comprehensively assess reasons for recalls of spinal implant devices used in patients over the past 21 years. Summary Background Data. The number spine on market continues to rise. Although Food Drug Administration (FDA) regulates safety these devices, there is a paucity literature are recalled. Methods. FDA device recall database was queried using search term “spine” between 2003 2024. Data were collected...
Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when the pathogen eludes or overwhelms host immune system. While effective vaccines and immunotherapies to prevent treat MSKI should be possible, fundamental knowledge gaps our understanding of protective, nonprotective, pathogenic immunity prohibitive. We also lack critical how is affected by microbiome, implants, prior infection, nutrition, antibiotics, concomitant therapies, autoimmunity, other...
Background Surgical site infection (SSI) following spine tumor surgery results in delays radiation therapy and the initiation of systemic treatment. The study aims to assess risk factors for SSI malignancy-related spinal infections rates observed a single center with use betadine irrigation (BI) intrawound vancomycin powder (IVP). Methods Spine patients managed from 11/2012 11/2023 were identified using surgical database (JotLogs, Efficient Apps, Portland, Maine). Inclusion criteria...
The SARS CoV-2 (COVID-19) pandemic presented unprecedented challenges as communities attempted to respond the administration of a novel vaccine that faced cold chain logistical requirements and hesitancy among many, well complicated phased rollout plans changed frequently availability waxed waned. COVID-19 also disproportionately affected color with barriers accessing healthcare. In setting these difficulties, program was created specifically address inequity in focus on linguistic diversity...
Introduction/Purpose: Achilles tendon rupture is a common injury in the adult population. The role of operative and non- management remains controversial with development functional rehabilitation programs. purpose this study to evaluate compare patient-reported outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS) after non-operative treatment acute rupture. PROMIS valid, reliable, effective tool patient for ruptures. Our hypothesis that there no significant...
Abstract Cutibacterium acnes , part of normal skin flora, is increasingly recognized as an opportunistic pathogen capable causing chronic prosthetic joint infections (PJI) associated with total hip and knee arthroplasty. However, there a paucity literature examining the pathogenesis C. during PJI. To study this, we developed implant‐associated osteomyelitis murine model in which 8–10‐week‐old C57BL6 mice were subjected to transtibial implantation titanium or stainless‐steel L‐shaped pins...
Retrospective cohort study.
ABSTRACT Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, cell-cell interactions between patients with FAI OA. In current study, by using integrative single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (Spatial-seq), we identified molecular mechanisms which cells promote OA...