A5027378720- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Ruminant Nutrition and Digestive Physiology
- Foot and Ankle Surgery
- Bone fractures and treatments
- Lower Extremity Biomechanics and Pathologies
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Breast Cancer Treatment Studies
- Elbow and Forearm Trauma Treatment
- Maternal and Perinatal Health Interventions
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Hip and Femur Fractures
- Hip disorders and treatments
- Breast Lesions and Carcinomas
- Shoulder Injury and Treatment
- Preterm Birth and Chorioamnionitis
- Milk Quality and Mastitis in Dairy Cows
- Airway Management and Intubation Techniques
- Antimicrobial Resistance in Staphylococcus
- Assisted Reproductive Technology and Twin Pregnancy
Virginia Commonwealth University
2015-2024
Orthopaedic Research of Virginia
2003-2019
Virginia Commonwealth University Medical Center
2013-2019
New York University Press
2019
Columbia University
2019
Institute of Cancer Research
2007-2017
Royal Manchester Children's Hospital
2015-2017
Breast Cancer Now
2017
Velindre NHS Trust
2017
University College London
2017
PURPOSE: To compare relapse rates and toxicity associated with para-aortic (PA) strip or PA ipsilateral iliac lymph node irradiation (dogleg [DL] field) (30 Gy/15 fractions/3 weeks) for stage I testicular seminoma. PATIENTS AND METHODS: Between July 1989 May 1993, 478 men seminoma (T1 to T3; no inguinoscrotal operation before orchiectomy) were randomized (PA, 236 patients; DL, 242 patients). RESULTS: Median follow-up time is 4.5 years. Eighteen relapses, nine in each treatment group, have...
To correlate articular cartilage function, as reflected in biomechanical properties and biochemical composition, with magnetic resonance (MR) imaging parameters of normal partially depleted matrix components.Normal from 12 porcine patellae was evaluated biomechanically, biochemically, MR (with without gadolinium enhancement). The were then enzymatically treated to deplete the either collagen or proteoglycan reevaluated imaging. Correlations between cartilaginous tissue function made....
The purpose of this study was to compare the response rate, overall and 1-year survival in patients with advanced melanoma treated a standard therapy, dacarbazine interferon-alpha (DTIC/IFN), or combination chemotherapy, consisting dacarbazine, BCNU, cisplatin tamoxifen (DBCT). Treatment toxicity time spent hospital were secondary end points. One hundred five (of whom 100 eligible) randomized receive either DTIC/IFN DBCT. trial designed detect 25% absolute difference rate 80% power. There no...
Falls in temperature the first nine hours after delivery were studied a group of 12 babies whose mothers had received diazepam labour, and 13 comparable not exposed to diazepam. A significantly lower mean was found test within three hours. Cord blood levels did correlate with either maternal at delivery, extent drop, or condition baby birth, though there an increased incidence assisted resuscitation infants group.
The current literature on femoroacetabular impingement (FAI) is focused acetabular orientation and femoral head asphericity, with little emphasis the effect of version neck. A biomechanical model was developed to determine causative effect, if any, retroversion hip contact stress and, present, delineate type FAI neck retroversion. Five pairs cadaveric hips (n = 10) were tested by loading in 90° flexion measured peak joint pressure location pressure. experiment repeated after performing a...
Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when the pathogen eludes or overwhelms host immune system. While effective vaccines and immunotherapies to prevent treat MSKI should be possible, fundamental knowledge gaps our understanding of protective, nonprotective, pathogenic immunity prohibitive. We also lack critical how is affected by microbiome, implants, prior infection, nutrition, antibiotics, concomitant therapies, autoimmunity, other...
The incidence of femur fracture around total hip arthroplasties continues to increase at substantial cost society. These fractures are frequently associated with a loose femoral component. Consequently, we sought test whether component loosening predisposes periprosthetic fracture. Because many spiral in nature, evaluated the torsional characteristics implanted which only design variable was instability We used synthetic (polyurethane) (n = 15) and paired cadaveric femora 10) specimens...
Surgical gloves can be damaged during the course of a procedure, which place surgeon and patient at risk. Glove perforation may not always readily apparent, determining risk factors for glove aid in deciding when change is advisable. Time wear needle sticks have been well studied; however, other mechanisms including mechanical stress from surgical equipment had limited evaluation to date.We evaluated that were caught rotatory device (such as drills reamers). The aims our study (1) determine...
Many different techniques for ankle arthrodesis have been described. Experience at our institution with crossed screws internal fixation has not met the 90+% union rate reported in literature. A compression blade plate is one technique which evaluated biomechanically. biomechanical study comparing two groups of sawbone fusion constructs fixed and plates was performed order to evaluate stiffness rigidity these techniques. The construct demonstrated superior during dorsiflexion (p < 0.001)...
Background Ruptured medial collateral ligaments are capable of healing over time, but biomechanical and biochemical properties remain inferior to normal tissue. Low-intensity ultrasound may improve healing. Hypothesis Medial treated with will demonstrate superior Study Design Controlled laboratory study. Methods Twenty-one late-adolescent male rabbits underwent bilateral ligament transection. One from each rabbit received treatment every other day for 6 total treatments. Contralateral sham...
Bony procedures play an essential role in the operative treatment of stage II posterior tibial tendon insufficiency and often substantially alter loading characteristics foot.Eight matched pairs cadaver lower extremities were axially loaded onto a TekScan HR Mat. (TekScan, Inc., South Boston, MA) After intact testing, each specimen had lateral column lengthening (either calcaneocuboid distraction arthrodesis [CCDA] or Evans procedure), medializing calcaneal osteotomy (MCO), plantarflexion...
Talonavicular fusion is performed for a variety of indications. This study examined the effects fixation techniques on plantar pressures, construct stiffness, and strength.Eight matched pairs cadaveric lower extremities were axially loaded intact after talonavicular with 3.5 reconstruction plate, plate plus cancellous screw (plate/screw), or three screws (screws). Recorded pressures divided into forefoot, two midfoot, hindfoot regions. Cantilevered bending excised constructs provided...
Background: This study evaluated the effects of locking vs nonlocking configuration on biomechanical performance a calcaneal reconstruction plate in an osteoporotic cadaveric model. Materials and Methods: A Saunders II B type fracture was created ten matched pair calcanei. Each fixed with Ascension using either or screws same hole pattern. Specimens were axially loaded for 1000 cycles through talus followed by load to failure. Statistical comparisons made between constructs displacements...