A5038050201- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Childhood Cancer Survivors' Quality of Life
- Reproductive Biology and Fertility
- Melanoma and MAPK Pathways
- Acute Myeloid Leukemia Research
- Vascular Tumors and Angiosarcomas
- Cancer, Hypoxia, and Metabolism
Izaak Walton Killam Health Centre
2021-2024
Dalhousie University
2021-2024
A comprehensive review and description of the clinical features that impact prognosis for patients with diffuse hemispheric glioma, H3 G34-mutant (G34-DHG) is needed. Understanding survival prognostic paramount advancements patient care.
The prognosis and treatment of pediatric low-grade gliomas is influenced by their molecular subtype. MR imaging remains the mainstay for initial work-up surgical planning. We aimed to determine relationship between patterns subtypes gliomas.This was a retrospective bi-institutional study patients diagnosed from 2004 2021 with pathologically confirmed molecularly defined as BRAF fusion, V600E mutant, or wild-type (which neither mutant nor fusion). Two neuroradiologists, blinded, independently...
The aim was to determine the impact of time diagnosis (TTD) on morbidity and mortality identify factors associated with overall survival (OS) in pediatric patients malignant central nervous system (CNS) tumors.This is a retrospective review all CNS tumors presenting 2 tertiary care hospitals from 2000 2019. Cox proportional hazard model analysis outcomes included TTD OS as well morbidity; stratified by tumor category, age, relapse, presence metastatic disease.There were 197 children (mean...
Abstract BACKGROUND Diffuse hemispheric glioma, H3 G34-mutant (G34-DHG) is generally associated with very poor outcome. Little known, however, regarding long-term survivors and prognostic factors. METHODS This retrospective, multicentre study was designed to investigate clinical, molecular, imaging variables that may impact the survival of patients G34-DHG. Patients any age diagnosed G34-DHG after January 1, 1995, at least one measure or progression were eligible. RESULTS 69 (62 G34R, 5...
10-20% of soft tissue sarcomas cannot be accurately classified with histology and immunohistochemistry (IHC) require further molecular investigation. We report an unclassified myoid neoplasm in a 5-year-old girl presenting localized left heel swelling impaired weight-bearing. Histology IHC determined this as undifferentiated sarcoma. Molecular work-up soft-tissue lesion demonstrated novel SRF-MKL2 fusion well chromosomal copy number anomalies including 1p, 6q, 22 loss, 1q gain. Pathologic...
Abstract OBJECTIVE: The prognosis and treatment of pediatric low-grade gliomas (pLGGs) is influenced by their molecular subtype. MRI remains the mainstay for initial work-up surgical planning. We aimed to determine relationship between imaging patterns subtypes pLGGs. METHODS: This a bi-institutional retrospective study patients diagnosed from 2004 2021 with pathologically confirmed pLGG, molecularly defined as BRAF fusion (KIAA1549-BRAF), V600E mutation, or wild-type (negative both mutation...
Abstract BACKGROUND: A comprehensive description of clinical features and factors impacting prognosis for patients with diffuse hemispheric glioma, H3 G34-mutant (DHG H3G34) is not easily accessible. Understanding survival data prognostic paramount advancements ensuring patients/families are fully informed. METHODS: To summarize clinical, basic histomolecular, treatment variables their impacts on DHG H3G34, a systematic review was undertaken. PubMed, Embase, Google Scholar were searched...
e22027 Background: Pediatric cancer patients undergoing treatment are often at risk for infertility or subfertility. Healthcare providers do not consistently deliver fertility information prior to therapy. Our objective was assess if development and implementation of a guideline improves the frequency pre-treatment discussions with pediatric families. Methods: This retrospective cohort study analyzed all consecutively eligible over two time periods. The pre-guideline period 18 months...
Abstract Background Diagnostic delays in pediatric neuro-oncology is a subject of distress for families and providers. We aimed to evaluate the symptom diagnostic interval (SDI) influencing variables children with CNS tumors. Methods This retrospective study analyzed 210 patients diagnosed from 2001–2018 managed at tertiary care facility Halifax, Canada. SDI was defined as time first until tissue diagnosis or, if not available, imaging diagnosis. Non-parametric tests were used compare...