A5000764134- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Inflammatory mediators and NSAID effects
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Neuroendocrine regulation and behavior
- Medication Adherence and Compliance
- Cardiovascular Health and Disease Prevention
- Pharmaceutical Economics and Policy
- Heart Rate Variability and Autonomic Control
- Health and Medical Studies
- Pharmacogenetics and Drug Metabolism
- Nitric Oxide and Endothelin Effects
- Eating Disorders and Behaviors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Syncope and Autonomic Disorders
- Fatty Acid Research and Health
- Evolutionary Psychology and Human Behavior
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
Osnabrück University
2011-2024
LVR-Klinik Bonn
2024
Hypertension Institute
2014
National Institute for Health Research
2013
Novartis (Switzerland)
2013
University College London
2013
University Hospital Bonn
2001-2012
University of Bonn
1985-2012
GTx (United States)
2009-2012
Boehringer Ingelheim (India)
2003
Body image disturbance is associated with several mental disorders. Previous research on body has focused mostly women, largely neglecting in men. Moreover, only a small number of studies have conducted gender comparisons over the lifespan and included participants aged 50 years older. With regard to measurement, often been assessed terms dissatisfaction, disregarding further aspects such as appreciation or importance appearance. The aim this cross-sectional study was explore different...
Introduction Pulse wave velocity (PWV) and augmentation index (AIx) are parameters of arterial stiffness reflection. PWV AIx strong indicators for cardiovascular risk used increasingly in clinical practice. Previous systems assessment investigator dependent time consuming. The aim this study was to validate the new oscillometric method (Arteriograph) determining by comparing it two clinically validated, broadly accepted tonometric piezo-electronic (SphygmoCor Complior). Design were measured...
The recent outbreak of the coronavirus disease (Covid-19) has plunged countries across world into crisis. Both in general population and specific subgroups such as infected people or health care workers, studies have reported increased symptoms anxiety, depression stress. However, reactions individuals with mental disorders to Covid-19 largely been neglected. present study therefore aimed investigate perceived impact its psychological consequences on disorders. In this online survey,...
AbstractThe present open and prospective study was performed to investigate the effect of angiotensin II receptor blocker (ARB) valsartan on sexual function in hypertensive males. Patients who were either newly treated or switched from other treatment regimens received 80–160 mg/day. Blood pressure decreased an average 158/94 mmHg 136/82 during 6 months (p < 0.001). The patients' assessed before after using International Index Erectile Function (IIEF), internationally validated 15‐item...
In the present study we describe intracellular pathways for transmission of growth signals by potent vasoconstricting eicosanoids prostaglandin H2 and thromboxane A2 in smooth muscle cells from rat aorta. Carbocyclic U46619 are stable mimetics acting at common A2/prostaglandin receptor. (10(-6) mol/L) induced an approximately 2.5-fold increase [Ca2+]i above basal value 25 seconds. Maximal stimulation 42-kD mitogen-activated protein kinase isoform both occurred 5 minutes. Both a concentration...
Post-Stroke Depression (PSD) is a severe condition, affecting about 30% of stroke survivors within five-year period after stroke. Post-stroke functional impairments (FI) and social support are associated with PSD. It inconclusive, whether one the factors, post-stroke FI PSD, shows stronger predictive value on respective other over time. The aims present study were to 1) investigate relationship between FI, patients in 3-year prospective design, 2) address methodological shortcomings previous...
Elevated brachial blood pressure (BP) is associated with increased cardiovascular risk and predicts morbidity mortality in humans. Recently, 24-hour ambulatory BP monitoring assessment of central aortic have been introduced to improve phenotyping. The Ambulatory Central Aortic Pressure (AmCAP) study combines these approaches describes, for the first time, diurnal patterns simultaneously measured pressures a prespecified substudy embedded within clinical trial lowering patients hypertension....
1. Aprotinin, a potent kallikrein inhibitor, was given to conscious rats with and without expansion of the extracellular fluid volume isotonic saline. 2. In non-expanded aprotinin had no effect on arterial pressure, glomerular filtration rate (GFR), hippuran clearance, urinary flow rate, absolute sodium potassium excretion or free-water clearance. 3. volume-expanded significantly reduced GFR, urine (V) UNaV, UKV Cwater/GFR systemic pressure. 4. Urinary immunoreactive prostaglandin E2...