A5017386550- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Musculoskeletal pain and rehabilitation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Metal-Catalyzed Oxygenation Mechanisms
- Biotin and Related Studies
- Mindfulness and Compassion Interventions
- Microbial Fuel Cells and Bioremediation
- Histone Deacetylase Inhibitors Research
- Protein Structure and Dynamics
- Complementary and Alternative Medicine Studies
- Receptor Mechanisms and Signaling
- Stroke Rehabilitation and Recovery
- Click Chemistry and Applications
- Enzyme Catalysis and Immobilization
- Ubiquitin and proteasome pathways
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metal Alloys Wear and Properties
- Cancer survivorship and care
- Balance, Gait, and Falls Prevention
- Protein Degradation and Inhibitors
- High Temperature Alloys and Creep
- Autophagy in Disease and Therapy
Zhengzhou University
2018-2025
Beijing Research Institute of Mechanical and Electrical Technology
2023
Shanghai Municipal Center For Disease Control Prevention
2020-2021
Henan Provincial Center for Disease Control and Prevention
2021
University of Chinese Academy of Sciences
2018-2021
Shanghai Municipal Commission of Health and Family Planning
2021
Shanghai Medical Information Center
2016-2019
Chinese Academy of Sciences
2012-2018
Institute of Biophysics
2012-2018
University of Liverpool
2018
Abstract Advances in RNA research and nanotechnology depend on the ability to manipulate probe with high precision through chemical approaches, both vitro mammalian cells. However, covalent labeling methods scope versatility comparable those of current protein strategies are underdeveloped. A method is reported for site‐ sequence‐specific RNAs cells by using tRNA Ile2 ‐agmatidine synthetase (Tias) click chemistry. The crystal structure Tias complex an azide‐bearing agmatine analogue was...
Incorporation of 3-methoxytyrosine boosts the oxidase activity myoglobin model oxidase, stressing importance redox potential tuning tyrosine.
ET encounters jellyfish: Through the incorporation of metal-chelating amino acid pyTyr into green fluorescent protein (GFP) from jellyfish, photoinduced electron transfer (ET) GFP chromophore to a bound CuII ion was shown occur within one nanosecond in distance-dependent manner. The crystal structure with at specific position shows structural basis for nanomolar binding affinity ions.
Abstract Background As a bio‐psycho‐social issue, chronic low back pain ( CLBP ) has been significant topic in health management, and patients' quality of life QOL is gaining extensive attention. Self‐efficacy, fear‐avoidance belief FAB ), coping styles play important roles the patients. However, it remains unclear how self‐efficacy influence through specific styles. This study aimed to explore influencing paths self‐efficacy, , on patients with . Methods relies multisite, cross‐sectional...
Maternal deprivation (MD) is frequently used as an early life stress model in rodents to investigate behavioral and neurological responses under stressful conditions. However, the effect of MD on postnatal development rodents, which when multiple neural systems become established, rarely investigated due methodological limitations. Ultrasonic vocalizations (USVs) are one few produced by neonatal that can be quantitatively analyzed, quantification USVs regarded a novel approach possible...
Chronic low back pain (CLBP) has become a worldwide health concern, and emotional distress is an important issue for CLBP management. However, it remains poorly understood how happens develops. This study aimed to systematically explore the correlates of in patients with CLBP.The was multisite, cross-sectional survey sample 252 urban communities. A battery questionnaires used collect data. Univariate analysis, Pearson correlation hierarchical linear regression analysis were performed.The...
Abstract Advances in RNA research and nanotechnology depend on the ability to manipulate probe with high precision through chemical approaches, both vitro mammalian cells. However, covalent labeling methods scope versatility comparable those of current protein strategies are underdeveloped. A method is reported for site‐ sequence‐specific RNAs cells by using tRNA Ile2 ‐agmatidine synthetase (Tias) click chemistry. The crystal structure Tias complex an azide‐bearing agmatine analogue was...
ET trifft Qualle: Die Einführung der Metallionen chelatisierenden Aminosäure pyTyr in Grün fluoreszierendes Protein (GFP) aus Quallen ermöglicht einen abstandsabhängigen photoinduzierten Elektronentransfer (ET) vom GFP-Chromophor auf ein gebundenes CuII-Ion binnen einer Nanosekunde. Eine Kristallstruktur von GFP mit an bestimmten Position offenbart die strukturelle Grundlage für nanomolare Bindungsaffinität CuII-Ionen. Detailed facts of importance to specialist readers are published as...
There are few cases where tyrosine has been shown to be involved in catalysis or the control of despite its ability carry out chemistry at much higher potentials (1 V versus NHE). Here, it is that a blocks hydrophobic substrate-entry channel copper-haem nitrite reductases can activated like switch by treatment crystals Ralstonia pickettii reductase ( Rp NiR) with nitric oxide (NO) (−0.8 ± 0.2 V). Treatment NO results an opening originating from rotation Tyr323 away Asp CAT 97. Remarkably,...
83 Structures of human nNOS, 55 structures eNOS, 13 iNOS, and about 126 reported NOS-bound compounds are summarized analyzed. Structural statistical analysis show that, at least one copy each analyzed compound binds to the active site (the substrate arginine binding site) NOS. And features three isoforms differences, but preference is not in way helpful for inhibitor design targeting nNOS or activator eNOS. This research shows that there a strong structural functional similarity between...
Classical enzyme kinetic theories are summarized and linked with modern discoveries here. The sequential catalytic events along time axis by analyzed at the molecular level, using master equations, this writing tries to connect microscopic behavior of data (like velocity coefficient k) obtained in experiment: 1/k = t equals sum times taken constituent individual steps. relationships between k, rate or velocity, amount each step physical biochemical conditions system discussed, perspective...
The arginyl-tRNA synthetase (ArgRS) catalyzes the esterification reaction between L-arginine and its cognate tRNA(Arg). Previously reported structures of ArgRS shed considerable light on tRNA recognition mechanism, while aspect amino acid binding in remains largely unexplored. Here we report first crystal structure E. coli (eArgRS) complexed with L-arginine, a series mutational studies using isothermal titration calorimetry (ITC). Combined previously work ArgRS, our results elucidated...