A5058603665- Tea Polyphenols and Effects
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Diet and metabolism studies
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemicals and Antioxidant Activities
- Cardiovascular Health and Disease Prevention
- Calibration and Measurement Techniques
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Food Quality and Safety Studies
- Nail Diseases and Treatments
- Advanced Glycation End Products research
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Dermatological diseases and infestations
- GDF15 and Related Biomarkers
- Acne and Rosacea Treatments and Effects
- Cerebrovascular and Carotid Artery Diseases
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Diet, Metabolism, and Disease
The Ohio State University
2017-2024
Rochester Institute of Technology
2018
Metabolic endotoxemia initiates low-grade chronic inflammation in metabolic syndrome (MetS) and provokes the progression towards more advanced cardiometabolic disorders. Our recent works obese rodent models demonstrate that catechin-rich green tea extract (GTE) improves gut barrier integrity to alleviate translocation of gut-derived endotoxin its consequent pro-inflammatory responses mediated through Toll-like receptor-4/nuclear factor κB (TLR4/NFκB) signaling. The objective this clinical...
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect against metabolic endotoxemia by decreasing intestinal permeability and absorption gut-derived endotoxin. However, translation to human health has not been established. We hypothesized that GTE would reduce gut systemic inflammation persons with syndrome (MetS) compared healthy persons. A randomized, double-blind, placebo-controlled, crossover trial adults(n=19, 34±2 y) adults MetS(n=21, 40±3...
Scope Catechin‐rich green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) by lowering endotoxin‐TLR4 (Toll‐like receptor‐4)‐NFκB (nuclear factor kappa‐B) inflammation. This study aimed to define altered MS‐metabolomic responses during high‐fat (HF)‐induced NASH that are restored GTE utilizing livers from an earlier in which decreased endotoxin‐TLR4‐NFκB liver injury. Methods and results Mice fed a low‐fat (LF) or HF diet for 12 weeks then randomized LF diets containing 0% 2%...
Poor diet quality influences cardiometabolic risk. Although potatoes are suggested to adversely affect health, controlled trials that can establish causality limited. Consistent with being rich in micronutrients and resistant starch, we hypothesized their inclusion a Dietary Guidelines for Americans (DGA)-based dietary pattern would improve gut health metabolic syndrome (MetS) persons. In randomized cross-over trial, MetS persons (n = 27; 32.5 ± 1.3 year) consumed DGA-based 2 weeks...
Nonalcoholic steatohepatitis (NASH) increases hepatocellular carcinoma (HCC) risk.
Catechin-rich green tea extract (GTE) limits inflammation in nonalcoholic steatohepatitis (NASH) consistent with a Toll-like receptor 4 (TLR4)-dependent mechanism. It is hypothesized that GTE supplementation during NASH will shift the hepatic metabolome similar to attributed loss-of-TLR4 signaling.
The use of small unmanned aircraft systems (sUAS) for applications in the field precision agriculture has demonstrated need to produce temporally consistent imagery allow quantitative comparisons. In order these aerial images be used identify actual changes on ground, conversion raw digital count reflectance, or an atmospherically normalized space, needs carried out. This paper will describe experiment that compares reflectance calibration panels, with empirical line method (ELM), against a...
Preclinical evidence demonstrated that catechin-rich green tea extract (GTE) improves gut barrier function and reduces intestinal systemic inflammation. Thus, this clinical trial was conducted to test the hypothesis GTE would alleviate inflammation relative cardiometabolic risk in persons with metabolic syndrome (MetS). We a randomized, double-blind, placebo-controlled, crossover adults MetS age- gender-matched healthy who received confections without (placebo) or 1 g/d (890 mg catechins)...
Obesity-related cardiometabolic disorders are driven by inflammation, oxidative stress, and gut dysbiosis. Green tea catechins protect against anti-inflammatory, antioxidant, prebiotic activities. However, whether obesity alters catechin bioavailability remains unknown. We hypothesized that would decrease due to altered microbiota composition. Obese healthy persons completed a pharmacokinetics trial in which confection formulated with green extract (GTE; 58% epigallocatechin gallate, 17%...
Catechins in green tea extract (GTE) (epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (EC), (ECG)) vary bioactivity. We developed a physiologically relevant mathematical model of catechin metabolism to test the hypothesis that fractional catabolic rates catechins would be differentially affected by their structural attributes. Pharmacokinetic data plasma and urine concentrations were used from healthy adults (n = 19) who ingested confections containing 0.5 g GTE (290 mg...
The predominant catechins [epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (EC), (ECG)] in green tea extract (GTE) vary bioactivity. Our objective was to develop a physiologically relevant mathematical model of catechin metabolism and assess their fractional catabolic rates relative structural attributes, which may influence bioactivities. Pharmacokinetic data were collected from healthy adults (n = 18; 27 ± 7 y; 22 2 kg/m2) after oral intake 0.5 g GTE (EGCG: 290 mg,...
Green tea extract (GTE) reduces NFκB‐mediated inflammation during nonalcoholic steatohepatitis (NASH). We hypothesized that its antiinflammatory activities would be mediated along the gut‐liver axis in a Toll‐like receptor‐4 (TLR4)‐dependent manner. Wild‐type (WT) and loss‐of‐function TLR4‐mutant (TLR4m) mice were fed high‐fat diet containing 0 or 2% (w/w) GTE for 8 wk before assessing NASH, inflammation, TLR4 adaptor proteins [myeloid differentiation 88 (MyD88) TIR‐domain‐containing...
Nonalcoholic steatohepatitis (NASH) increases hepatocellular carcinoma (HCC) risk by increasing inflammation and oncogenesis. Antiinflammatory activities of green tea extract (GTE) protect against dietary high‐fat (HF)‐induced NASH. We hypothesized that the hepatoprotective antiinflammatory GTE during NASH would also prevent diethylnitrosamine (DEN)‐induced progression towards HCC. Male C57BL/6J mice (4 wk old) were fed a HF diet devoid of, or supplemented with, at 2% (w/w) received once...
The use of small unmanned aircraft systems (sUAS) for applications in the field precision agriculture has demonstrated need to produce temporally consistent imagery allow quantitative comparisons. In order these aerial images be used identify actual changes on ground, conversion raw digital count reflectance, or an atmospherically normalized space, needs carried out. This paper will describe experiment that compares reflectance calibration panels, with empirical line method (ELM), against a...
Green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) through a mechanism involving the gut-liver axis by limiting endotoxin-TLR4-NFκB inflammation, but independent bioactivities of specific green catechins have not been defined. We hypothesized that epigallocatechin gallate (EGCG) and catechin (CAT) would protect against NASH, to lesser extent than GTE. Male, 6-wk old C57BL6/J mice were provided diet formulated be low-fat (LF), high-fat (HF), or HF containing GTE (2%), EGCG...
Green tea extract (GTE) protects against obesity in rodents by reducing gut permeability that otherwise provokes endotoxemia-mediated inflammation. However, whether affects catechin bioavailability and microbial metabolism is unknown. We hypothesized will reduce increasing biotransformation of catechins. Obese persons (n = 10 M/7F; 33.5 ± 0.7 kg/m2) age-matched healthy M/9F; 21.7 0.4 completed a pharmacokinetics (PK) trial which GTE confection [290 mg epigallocatechin gallate (EGCG), 87...
Restricting dietary sugar is a leading recommendation, but limited biomarkers assessing intake exist. Although 24-h urinary sucrose (U-Suc) and fructose (U-Fruc) excretion has been used with mixed success, collection burdensome.