A5078123690- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- Artificial Intelligence in Healthcare and Education
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Poisoning and overdose treatments
- Machine Learning in Healthcare
- Antibiotics Pharmacokinetics and Efficacy
- Topic Modeling
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Pharmacovigilance and Adverse Drug Reactions
- Anesthesia and Neurotoxicity Research
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Pressure Ulcer Prevention and Management
- Ethics in Clinical Research
- Blood disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Cardiac Ischemia and Reperfusion
- Drug-Induced Adverse Reactions
- Helminth infection and control
Elisabeth-TweeSteden Ziekenhuis
2022-2025
Erasmus MC
2025
Eindhoven University of Technology
2023
Radboud University Nijmegen
2013-2020
Radboud University Medical Center
2013-2020
University Medical Center
2020
Large Language Models (LLMs) offer considerable potential to enhance various aspects of healthcare, from aiding with administrative tasks clinical decision support. However, despite the growing use LLMs in a critical gap persists clear, actionable guidelines available healthcare organizations and providers ensure their responsible safe implementation. In this paper, we propose practical step-by-step approach bridge support warranting implementation into healthcare. The recommendations...
Abstract Background Large language models (LLMs) show increasing potential for their use in healthcare administrative support and clinical decision making. However, reports on performance critical care medicine is lacking. Methods This study evaluated five LLMs (GPT-4o, GPT-4o-mini, GPT-3.5-turbo, Mistral 2407 Llama 3.1 70B) 1181 multiple choice questions (MCQs) from the gotheextramile.com database, a comprehensive database of at European Diploma Intensive Care examination level. Their was...
Abstract Objectives Piperacillin/tazobactam combined with vancomycin has been associated a decline in renal function when compared monotherapy. Teicoplanin is glycopeptide similar to vancomycin. We investigated whether piperacillin/tazobactam teicoplanin as well. Methods conducted single-centre retrospective cohort study data from our electronic health records 9 August 2013 15 November 2019, including all adult patients that received either piperacillin/tazobactam, or + teicoplanin. The...
Severe metformin overdose can result in life-threatening conditions such as metabolic acidosis with hyperlactatemia and vasoplegic shock. Current treatment guidelines recommend hemodialysis supportive care. However, this case report presents the use of methylene blue an additional for severe overdose-induced shock, which is not commonly described literature or guidelines.A 55-year-old woman presented to emergency department after ingesting 82.5 g metformin, resulting refractory Despite...
Neuromuscular blocking agents are regularly used in the intensive care unit (ICU) to facilitate mechanical ventilation patients with acute respiratory distress syndrome and patient-ventilator dyssynchronies. However, prolonged neuromuscular blockade is associated adverse effects like ICU-acquired weakness. Residual is, however, not routinely monitored unit, as such, this phenomenon might be unrecognized underreported. We report a case which an unusual effect of was seen after cessation drug,...
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of lethal Aspergillus niger infection patient. Immunological tests showed an impaired innate adaptive immune response to Aspergillus. A history COPD, unresponsiveness antibiotics especially suggestive CT-scan should trigger clinician consider diseases caused by
Augmented renal clearance (ARC) is a pathophysiological phenomenon that can occur in critically ill patients, leading to enhanced function. It defined as creatinine of >130 mL/min/1.73 m2 . ARC lead subtherapeutic levels renally cleared drugs and subsequent treatment failure. In COVID-19, it has only been described the literature few cases. We present case 38-year-old patient with COVID-19 who developed an initial 226 , persisting for 30 days. He required high doses sedatives neuromuscular...
Amphotericin B is a broad-spectrum antifungal agent that used in the treatment of systemic fungal infections. We describe case 62-year-old female patient with recent aneurysmal subarachnoid hemorrhage who was treated for suspected ventriculitis and coinfection. Instead liposomal amphotericin (L-AmB), 465 mg (5 mg/kg) deoxycholate (DOC) inadvertently administered, leading to refractory shock multiple organ failure requiring mechanical ventilation. Since an overdose can lead fatal consequences...
Amphotericin B is a broad-spectrum antifungal agent that used in the treatment of systemic fungal infections. We describe case 62-year-old female patient with recent aneurysmal subarachnoid hemorrhage who was treated for suspected ventriculitis and coinfection. Instead liposomal amphotericin (L-AmB), 465 mg (5 mg/kg) deoxycholate (DOC) inadvertently administered, leading to refractory shock multiple organ failure requiring mechanical ventilation. Since an overdose can lead fatal consequences...