A5064706251- Dendrimers and Hyperbranched Polymers
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Organic and Molecular Conductors Research
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Organometallic Complex Synthesis and Catalysis
- Nonlinear Optical Materials Studies
- Asymmetric Hydrogenation and Catalysis
- Advanced biosensing and bioanalysis techniques
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Covalent Organic Framework Applications
- Molecular Sensors and Ion Detection
- Polyoxometalates: Synthesis and Applications
- Organophosphorus compounds synthesis
- Advanced Polymer Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Nanoparticle-Based Drug Delivery
- Organometallic Compounds Synthesis and Characterization
Centre National de la Recherche Scientifique
2012-2023
Université de Toulouse
2012-2023
Laboratoire de Chimie de Coordination
2011-2023
Université Toulouse III - Paul Sabatier
2009-2018
Institut National Polytechnique de Toulouse
2012-2017
Institut UTINAM
2008-2012
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
2011
Moroccan Foundation for Advanced Science, Innovation and Research
2011
Saarland University
2008
Université de Sherbrooke
2008
Gene therapy, in which oligomeric genetic material is carried into cells by nano-sized gene delivery vehicles to interfere with expression, represents a promising approach for preventive therapy against HIV/AIDS pandemic. Herein, we evaluate the usefulness of phosphorus-containing dendrimer G4(NH+Et2Cl-)96 as agent ODNs and siRNAs. formed stable complexes or siRNAs exhibited very low cytotoxicity Sup T1 PBMC. Functional validation was performed using specific siRNA HIV-1 Nef, siNEF...
A series of novel monomeric and dendritic thiazolyl phosphines (generations 1 3) was prepared the activity these ligands conferred to palladium in Suzuki couplings evaluated. The heteroaryl were revealed be very efficient able perform reactions mild conditions. Besides, their efficiency compared that corresponding triphenylphosphines. Moreover, possibility reuse both families explored phosphine-based catalytic systems could successfully recycled for five consecutive without loss activity,...
Controlled titanium alkoxide mineralization in the presence of phosphonated, dendrimeric nano-building blocks provides a new family hierarchically porous dendrimer-bridged dioxide materials.
The dinuclear gold complexes [{Au(PPh 3)} 2(mu- dmid)] ( 1) dmid = 1,3-dithiole-2-one-4,5-dithiolate) and dddt)] 2) dddt 5,6-dihydro-1,4-dithiine-2,3-dithiolate) were synthesized characterized by X-ray crystallography. Both exhibit intramolecular aurophilic interactions with Au...Au distances of 3.1984(10) A for 1 3.1295(11) 2. self-assembly reaction between 4,5-bis(2-hydroxyethylthio)-1,3-dithiole-2-thione (HOCH 2 CH ) dmit) [AuCl(tht)] affords the complex [AuCl{ dmit}] 4), which possesses...
Abstract The need to design organocatalysts or water‐soluble catalysts for a number of reactions industrial interest helps explain the renewed in ligands which allow such take place. Among them, “cage‐like” phosphines, known some time, offer new perspectives as also do their corresponding metal transition complexes. role these ligands, Verkade‐type bases, 1,3,5‐triaza‐7‐phosphatricyclo[3.3.1.1]decane (PTA), 2,4,10‐trimethyl‐1,2,4,7,10‐hexaaza‐3‐phosphatricyclo[3.3.1.1 3,7 ]decane (THPA), and...
Functionalized phenols based on tyramine were synthesized in order to be selectively grafted hexachlorocyclotriphosphazene, affording a variety of functionalized dendrons type AB(5). The B functions comprised fluorescent groups (dansyl) or dyes (dabsyl), whereas the A function was provided by either an aldehyde amine. characterization these is reported. An unexpected behaviour and water-soluble dendron dansyl mixtures dioxane/water observed.
Aims: The objective was to study if cationic phosphorus dendrimers can be used as DC-based vaccine or adjuvant in anti-HIV-1 development when associated with HIV-1 derived peptides. Materials & Methods: HIVderived peptides uptake DC and the phenotype of iDC mDC were studied using Flow Cytometry analysis. Migration evaluated by an vitro chemotaxis assay. Allogenic T-cells proliferative response induced assays. Cytokines production analysed Diaclon DIAplex Th1/Th2/Inflammation kit. Results:...
Abstract The versatile reactivity of hexachlorocyclotriphosphazene (N 3 P Cl 6 ) has been developed for the synthesis specifically engineered dendrimers. Dendrimers are hyperbranched macromolecules built by concentric layers constituted associated monomeric units. Many properties dendrimers depend on type their surface (terminal) functions, which generally all identical. For some specific purposes, it is desirable to have one function that different at level core....
Polyphosphorhydrazone (PPH) dendrimers have been grafted on silica nanoparticles, and the surface functions of derivatized to phosphonates with lateral poly(ethyleneglycol) (PEG) chains. All materials thoroughly characterized by MAS NMR, FT-IR, electron microscopy, TGA elemental analysis. These successfully hosted silver oxide nanoparticles. The resulting composites exhibit antibacterial activity.
The synthesis of a G0 polyamidoamide (PAMAM) dendrimer end‐capped with four β‐cyclodextrin (β‐CD) units, named as Tetra‐CD was performed by using copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC). This new platform presents considerable high water‐solubility in comparison to native β‐CD. Tumbling process involving half the CD cavities D 2 O evidenced 1 H NMR spectroscopy. Interaction adamantane has been fully investigated 1D/2D techniques and mass spectrometry besides joint study on...
ABSTRACT The synthesis of new series PPH (poly(phosphorhydrazone)) dendrimers with amino‐PEG phosphonates or the corresponding phosphonic acids as terminal groups is presented, from generations 1–3. size PEG‐terminated experimentally measured by diffusional NMR, and means dynamic light scattering. Classical molecular dynamics well‐tempered metadynamics simulations are used to assess confirm formation aggregates in some cases. influence PEG capping on cytotoxicity profiles evaluated human...
Novel organosilylated tetrathiafulvalenes (TTFs) possessing Si-H or Si-Si bonds have been synthesised. The crystal structures of several derivatives determined by X-ray diffraction, including that dimeric (Si2Me4)(TTF)2 (11) incorporating a diatomic SiMe2-SiMe2 linker. Cyclic voltammetry measurements in all cases show two oxidation waves. DFT calculations were performed to rationalize the absence an electronic communication between TTF moieties 11 through disilanyl spacer. reactivity bond...
Various strong non-ionic phosphazene bases were obtained by a new, efficient and very simple method involving the lithium phosphonium azayldiide Ph3P=NLi as precursor.
Bis[(dimethoxyphosphoryl)methyl)]amino- and bis(phosphonomethyl)amino-terminated samples of poly(ethylene glycol) (PEG) were prepared from commercially available PEG in fair-to-good yields by means adaptations the Moedritzer–Irani Kabachnik–Fields procedures, respectively. An alternative route involving silylation phosphonates subsequent methanolysis to afford phosphonic acid groups was also examined.
Playing with the versatile reactivity of thiazole and phosphorus derivatives leads to active ligands complexes in catalysis.
Difluoroboron complexes of monomeric and dimeric diketones generations 0–4 phosphorus dendrimers ended by diketone ligands are synthesized characterized. Their photoluminescence properties measured. All compounds exhibit an intense absorption band in the near UV region. Both model dimers show a marked hypsochromic shift this compared with difluoroboron complex. The fluorescence dioxaborine complex subunit multichromophoric dendritic architectures is quenched emission isolated fluorophore,...
Abstract This review presents the synthesis of dendrons (dendritic wedges) based on cyclotriphosphazene cores, in which one function is a fluorescent group, and five remaining functions are used for growing dendritic branches. The branches carried out by divergent method, using two‐step process implies hydroxybenzaldehyde phosphorhydrazide H 2 NNMeP(S)Cl . Four different fluorophores have been used, derived from maleimide, julolidine, pyrene, or near‐infra‐red fluorophore. Depending type...