A5080477542- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Neuroscience and Neural Engineering
- Gene Regulatory Network Analysis
- Planarian Biology and Electrostimulation
- Diabetic Foot Ulcer Assessment and Management
- Immune cells in cancer
- Evolution and Genetic Dynamics
- Advanced Sensor and Energy Harvesting Materials
- Photoreceptor and optogenetics research
- Analytical Chemistry and Sensors
- Traffic control and management
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
- Ecosystem dynamics and resilience
- Species Distribution and Climate Change
- Nonlinear Dynamics and Pattern Formation
- Vehicular Ad Hoc Networks (VANETs)
- Microfluidic and Capillary Electrophoresis Applications
- Transportation Planning and Optimization
- Plant and Biological Electrophysiology Studies
- Smart Agriculture and AI
- Leaf Properties and Growth Measurement
- Stability and Control of Uncertain Systems
- Advanced Memory and Neural Computing
University of California, Santa Cruz
2017-2024
Applied Mathematics (United States)
2019-2024
University of California, Berkeley
2016-2017
Rice University
2015
California Institute of Technology
2012-2014
Universitat Autònoma de Barcelona
1999
In this paper we investigate connected cruise control in which vehicles rely on ad hoc wireless vehicle-to-vehicle communication to their longitudinal motion. Intermittencies and packet drops channels are shown introduce stochastic delays the feedback loops. Sufficient conditions for almost sure stability of equilibria derived by analyzing mean covariance dynamics. addition, concept nσ string is proposed characterize input-output response steady state. The results summarized using charts...
ABSTRACT The spatial organization of microbial communities arises from a complex interplay biotic and abiotic interactions, is major determinant ecosystem functions. Here we design microfluidic platform to investigate how the arrangement microbes impacts gene expression growth. We elucidate key biochemical parameters that dictate mapping between positioning patterns. show distance can establish low-pass filter periodic inputs enhance fidelity information processing. Positive negative...
Evaluating and tracking wound size is a fundamental metric for the assessment process. Good location estimates can enable proper diagnosis effective treatment. Traditionally, laboratory healing studies include collection of images at uniform time intervals exhibiting wounded area process in test animal, often mouse. These are then manually observed to determine key metrics —such as progress— relevant study. However, this task time-consuming laborious In addition, defining edge could be...
Wildland conservation efforts require accurate maps of plant species distribution across large spatial scales. High-resolution mapping is difficult in diverse, dense communities, where extensive ground-based surveys are labor-intensive and risk damaging sensitive flora. satellite imagery available at scales needed for community areas, but can be cost prohibitive lack resolution to identify species. Deep learning analysis drone-based aid classification these communities regions. This study...
The regulation of most physiological processes relies on a state equilibrium called homeostasis, which is achieved through biological control loop involving sensors and actuators. However, disease aging can disrupt these loops, leading to impaired or slower homeostatic mechanisms. Bioelectronic devices offer the opportunity interface artificial technology with systems, enabling measurement specific using To effectively interact complex dynamics adapt changing environmental conditions,...
Abstract The ability to deliver drugs with precise dosages at specific time points can significantly improve disease treatment while reducing side effects. Drug encapsulation for gradual delivery has opened the doors a superior regimen. To expand on this ability, programming bioelectronic devices small molecules enables ad‐hoc personalized therapeutic profiles that are more complex than release. Here, wearable device an integrated electrophoretic ion pump affords on‐demand drug dose control...
In this paper we investigate the concept of connected cruise control (CCC) where vehicles rely on ad-hoc wireless vehicle-to-vehicle (V2V) communication to their longitudinal motion. While V2V potentially allows build detailed knowledge about traffic environment, intermittencies and packet drops introduce stochastic delays into channels that make very challenging. Moreover, while occurs in discrete time, vehicle dynamics still takes place continuous time. We convert time analyze effects...
From the simplest unicellular organisms to complex animals, feedback control based on sensing and actuation is a staple of self‐regulation in biological processes key life itself. Malfunctioning this loop can often lead disease or death. Bioelectronic devices that interface electronics with systems be used for have potential novel therapeutic applications. Due complexity challenge affecting their innate self‐regulation, closing between bioelectronics difficult achieve. Herein, bioelectronic...
The capacity of machine-learning methods to handle large and complex datasets makes them suitable for applications in precision medicine. Current automate data analysis predict physiological outcomes patients with various types clinical inform treatment strategies. In this perspective, we propose ways which machine learning can be leveraged even further advance optimizing patient treatment. Namely, used expand feedback control direct the response biological systems predictably automatically....
Abstract Background Wound healing involves careful coordination among various cell types carrying out unique or even multifaceted functions. The abstraction of this complex dynamic process into four primary wound stages is essential to the study care for timing treatment and tracking progression. For example, a that may promote in inflammatory stage prove detrimental proliferative stage. Additionally, time scale individual responses varies widely across within same species. Therefore, robust...
Impaired wound healing affects millions worldwide, especially those without timely healthcare access. TheraHeal provides a portable, wireless platform for real-time, continuous, and personalized care. The integrates wearable device imaging delivery of therapy with an AI Physician. Physician analyzes images, diagnoses the stage, prescribes therapies to guide optimal healing. Bioelectronic actuators in deliver therapies, including electric fields or drugs, dynamically closed-loop system....
Wound infections are a significant medical challenge, often leading to chronicity or systemic infection. Selective serotonin reuptake inhibitors (SSRIs) have emerged as potential non-antibiotic candidates with demonstrated ability limit growth and biofilm formation in Gram-negative bacteria, addition their pro-healing activity. Here, we compared direct delivery of the SSRI fluoxetine by topical bolus dosing from an iontophoresis bandage device actuator for temporally controlled drug...
The development of wearable bioelectronic systems is a promising approach for optimal delivery therapeutic treatments. These can provide continuous ions, charged biomolecules, and an electric field various medical applications. However, rapid prototyping controlled specific treatments with scalable fabrication process challenging. We present system comprised polydimethylsiloxane (PDMS) device cast in customizable 3D printed molds circuit board (PCB), which employs commercially available...
Bioelectronic devices have shown their unprecedented potential in a wide range of biomedical applications due to vast functionality. To fully unleash potential, bioelectronic should be able precisely respond real-time changes the environment drive biological systems' response towards desired goals. However, controlling with is challenging presence uncertainties, stochasticity, unmodeled dynamics, and complex nonlinearities. Here, we demonstrate promise leveraging tools synthetic biology an...
A potentiostat is an essential piece of analytical equipment for studying electrochemical devices and reactions. As the design evolve, applications systems with multiple working electrodes have become more common. These drive a need low-cost multi-channel systems. We developed portable, scalable system modular that can support 8 to 64 channels at cost as low $8 per channel. This replace functionality commercial potentiostats which upwards $10k certain applications. Each channel in has...
Ions and biomolecules are signal carriers in biological systems transfer information for intracellular communication organism function. As such, bioelectronic devices that conduct ions rather than electrons holes provide an interface to monitor control physiological processes. These processes often affected by multiple distinct ionic species. Here, we develop ion pump can the delivery of species on same chip. We demonstrate on-chip H+, Na+, Cl− monitoring dynamic concentration change using...
Macrophages can exhibit pro-inflammatory or pro-reparatory functions, contingent upon their specific activation state. This dynamic behavior empowers macrophages to engage in immune reactions and contribute tissue homeostasis. Understanding the intricate interplay between macrophage motility status provides valuable insights into complex mechanisms that govern diverse functions. In a recent study, we developed classification method based on morphology, which demonstrated movement...
Precision medicine endeavors to personalize treatments, considering individual variations in patient responses based on factors like genetic mutations, age, and diet. Integrating this approach dynamically, bioelectronics equipped with real-time sensing intelligent actuation present a promising avenue. Devices such as ion pumps hold potential for precise therapeutic drug delivery, pivotal aspect of effective precision medicine. However, implementing bioelectronic devices encounters formidable...
Electrical signaling plays a crucial role in the cellular response to tissue injury wound healing and an external electric field (EF) may expedite process. Here, we have developed standalone, wearable, programmable electronic device administer well-controlled exogenous EF, aiming accelerate vivo mouse model provide pre-clinical evidence. We monitored process by assessing re-epithelization rate ratio of M1/M2 macrophage phenotypes through histology staining. Following three days treatment,...
Bioelectronic devices that interface electronics with biological systems can actuate and control processes. The potassium ion plays a vital role in cell membrane physiology, maintaining the potential (Vmem) generating action potentials. In this work, we present two bioelectronic pumps use an electronic signal to modulate concentration solution. first pump is designed integrate directly six-well culture plates for optimal ease of integration vitro culture, second on-chip provides high spatial...
Bioelectronics integrates electronic devices and biological systems with the ability to monitor control processes. From homeostasis sensorimotor reflexes, closed-loop feedback is a staple of most fundamental life itself. Apart from few examples in bioelectronic medicine, processes using bioelectronics not as widespread nature. We note that adoption has been slow because traditional methods are difficult apply complex dynamics their sensitivity environmental changes. Here, we postulate...