A5006217365- Nerve injury and regeneration
- Heart Rate Variability and Autonomic Control
- Venomous Animal Envenomation and Studies
- Optical Imaging and Spectroscopy Techniques
- Neurological disorders and treatments
- Geotechnical Engineering and Soil Mechanics
- Soil, Finite Element Methods
- Geotechnical Engineering and Underground Structures
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinoids in leukemia and cellular processes
- Non-Invasive Vital Sign Monitoring
- Color perception and design
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Ergonomics and Musculoskeletal Disorders
- Impact of Light on Environment and Health
- Parkinson's Disease Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
Fujimoto Pharmaceutical Corporation (Japan)
2019-2021
University of Fukui
2021
Tokyo Medical and Dental University
2017
Nagasaki University
2013
Abstract Glial glutamate transporter GLT1 plays a key role in the maintenance of extracellular homeostasis. Recent human genetic studies have suggested that de novo mutations (EAAT2) cause early‐onset epilepsy with multiple seizure types. Consistent these findings, global null mice show lethal spontaneous seizures. The consequences dysfunction vary between different brain regions, suggesting may also regions. In this study, we generated region‐specific knockout by crossing floxed‐GLT1...
In patients with Parkinson's disease (PD), non-motor symptoms (NMS) including depression and anxiety are often recognized before motor develop. Monoamine oxidase (MAO)-B inhibitors therapeutically effective for symptoms; however, their effects on NMS in PD yet to be fully assessed. Here, we aimed explore the antidepressant-like of propargyl MAO-B inhibitors, selegiline rasagiline, mice treated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a model, elucidate mechanisms underlying...
Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to gradual accumulation glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout body. Pain in extremities early symptom FD; however, underlying pathophysiological mechanisms remain unknown. α-Galactosidase A knockout animals exhibit nociceptive behaviors, with enhanced expression levels several ion channels. These characteristics are observed treated...
2011年東北地方太平洋沖地震では大規模で甚大な被害をもたらした液状化が発生したが,それ以降も,2016年熊本地震や2018年北海道胆振東部地震など,最大震度7を観測し,広い範囲で震度5強以上の強い揺れに見舞われ多くの地域で液状化が発生した.本研究では,詳細な航空写真画像による液状化判定が可能で,震度6弱以上を観測した,2011年東北地方太平洋沖地震,2016年熊本地震,2016年鳥取県中部の地震,2018年大阪府北部の地震,2018年北海道胆振東部地震の5つの地震の液状化発生地点の情報に基づき,4分の1地域メッシュ(以下,250mメッシュと呼ぶ)単位に基づく液状化発生率や250mメッシュ内の液状化面積を考慮した液状化面積率を推定し,液状化発生率と面積率の積による液状化危険率の推定式を提案した.
This study investigates the effect of blue light emitted by phosphor-converted white light-emitting diodes (LEDs) on people’s eye fatigue. We conducted an experiment in which participants performed a visual task under lighting conditions using LED (B-LED) excites phosphors and LEDs (V-LEDs) violet two types phosphors. One V-LEDs had spectral power distribution mimicking those sun (S-LED). During experiment, we measured participants’ subjective fatigue, number blinks, accommodation critical...
Many traffic accidents are caused by human error. In order to help prevent such error, we investigated brain hemodynamics in both the frontal and somatosensory areas functional near-infrared spectroscopy (fNIRS), electrocardiogram (ECG), following two types of task performance with vibratory stimulation: a Tracking Stroop test. To evaluate changes oxygenated hemoglobin concentration (oxyHb), used δoxyHb as previously defined (H. Iwasaki: Availability future prospects usability evaluation,...