A5070208025- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Hip and Femur Fractures
- Parasitic Diseases Research and Treatment
- Respiratory and Cough-Related Research
- Cardiac, Anesthesia and Surgical Outcomes
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Ion Channels and Receptors
- Inflammatory mediators and NSAID effects
- Planarian Biology and Electrostimulation
- Osteoarthritis Treatment and Mechanisms
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Photoreceptor and optogenetics research
- Pediatric Pain Management Techniques
- Spondyloarthritis Studies and Treatments
- Peroxisome Proliferator-Activated Receptors
- Pelvic and Acetabular Injuries
- Neuropeptides and Animal Physiology
- Bone fractures and treatments
- Dermatology and Skin Diseases
- Bone and Joint Diseases
First Affiliated Hospital of Fujian Medical University
2023-2025
Fujian Medical University
2023-2025
Putian University
2022-2025
The purpose of this study was to explore the clinical value metagenomic next-generation sequencing (mNGS) in diagnosis polymicrobial periprosthetic joint infection (PJI).Patients with complete data who underwent surgery at our hospital between July 2017 and January 2021 for suspected (PJI), according 2018 ICE diagnostic criteria, were enrolled, all patients microbial culture mNGS detection, which performed on BGISEQ-500 platform. Microbial cultures two samples synovial fluid, six tissue,...
Abstract Background A fundamental tenet of the hygiene theory is inverse association between helminth infections and emergence immune-mediated diseases. Research has been done to clarify processes by which helminth-derived molecules can inhibit immunological disorders. This study aimed evaluate ability Trichinella spiralis chitinase (Ts-chit) ameliorate symptoms allergic airway inflammation. Methods Recombinant (rTs-chit) was expressed in Escherichia coli BL21, its structural homology murine...
Abstract The interaction between the nervous system and immune during chronic bacterial infection remains unclear. Here, it is reported that Staphylococcus aureus ( S. ) induces calcitonin gene‐related peptide (CGRP) secretion from intra‐articular transient receptor potential cation channel subfamily V member 1 positive (TRPV1 + nociceptive nerves through its pore‐forming toxin (PFT) α‐hemolysin. released CGRP then inhibits production of chemotactic cytokines by CX3CR1 tissue‐resident...
Abstract Background The interaction between the nervous system and immune can affect outcome of a bacterial infection. Staphylococcus aureus skin infection is common infectious disease, elucidating relationship may help to improve treatment strategies. Results In this study, we found that local release calcitonin gene-related peptide (CGRP) increased during S. infection, could promote CGRP from transient receptor potential cation channel subfamily V member 1 (TRPV1 + ) neurons in vitro....
Many observational studies have found an association between Alzheimer's disease (AD) and osteoporosis. However, it is unclear whether there causal genetic osteoporosis AD.A two-sample Mendelian randomization (MR) study was used to investigate a relationship AD. Genes for AD were obtained from published the genome-wide (GWAS). Single nucleotide polymorphisms (SNPs) with significant differences (p < 5 × 10-8) independent (r2 0.001) selected, SNPs F ≥ 10 further analyzed. Inverse variance...
Abstract The pathogenesis of osteoarthritis (OA) is still unclear. Fatty acid binding protein 4 (FABP4), a novel adipokine, has been found to play role in OA. This study aimed explore the NF‐κB FABP4‐induced In vivo study, four pairs 12‐week‐old male FABP4 knockout (KO) and wild‐type (WT) mice were included. activation was assessed. parallel, 24 6‐week‐old C57/Bl6 fed high‐fat diet (HFD) randomly allocated groups: daily oral gavage with (1) PBS solution; (2) QNZ (NF‐κB‐specific inhibitor, 1...
Many observational studies have shown that obesity strongly affects skin and soft tissue infections (SSTIs). However, whether a causal genetic relationship exists between SSTIs is unclear. A two-sample Mendelian randomization (MR) study was used to explore causally associated with using publicly released genome-wide association (GWAS). An inverse-variance weighted (IVW) analysis as the primary analysis, results are reported odds ratios (ORs). Heterogeneity tested Cochran's Q test I2...
Abstract The role of nociceptive nerves in modulating immune responses to harmful stimuli via pain or itch induction remains controversial. Compared conventional surgery, various implant surgeries are more prone infections even with low bacterial loads. In this study, an optogenetic technique is introduced for selectively activating peripheral using a fully implantable, wirelessly rechargeable device. By targeting nociceptors the limbs awake, freely moving mice, it found that activation...
Aims This aim of this study was to analyze the detection rate rare pathogens in bone and joint infections (BJIs) using metagenomic next-generation sequencing (mNGS), impact mNGS on clinical diagnosis treatment. Methods A retrospective analysis conducted 235 patients with BJIs who were treated at our hospital between January 2015 December 2021. Patients divided into no-mNGS group (microbial culture only) (mNGS testing microbial culture) based whether used or not. Results total 147 included 88...
Objectives The study aimed to evaluate differences in clinical characteristics and treatment outcomes of periprosthetic joint infection (PJI) attributed rare versus common pathogens. Methods Data on PJI patients who underwent hip or knee arthroplasty at our center from April 2013 December 2022 were retrospectively collected. Among the 219 enrolled patients, we compared 32 cases caused by pathogens with 187 controls pathogens, analyzing demographic information, characteristics, outcomes....
Purpose This study aimed to introduce and investigate the safety efficiency of intraoperative central measurement method femoral head (IM-CMFH) prevent leg length discrepancies (LLD) after hemiarthroplasty. Methods Overall, 79 patients aged 75 85 years with neck fractures who underwent hemiarthroplasty were divided into two groups: Control group ( n = 46) IM-CMFH 33). The groups compared for postoperative LLD proportions greater than 10 mm, 6–10 within 5 offset (FO) difference incremental mm...
To investigate the feasibility of pre-drilling combined with a finger reduction tool for difficult-to-reduce intertrochanteric fractures.Patients diagnosed complicated fractures during period from July 2016 to May 2021 at Affiliated Hospital our College were enrolled in this study. All patients underwent by followed fixing proximal femoral nail antirotation. The outcome was evaluated intraoperative fluoroscopy. operation time, fluoroscopy frequency, and incidence postoperative complications...