A5063712604- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Thyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Streptococcal Infections and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Organ Transplantation Techniques and Outcomes
- interferon and immune responses
- Uterine Myomas and Treatments
- Pressure Ulcer Prevention and Management
- Pancreatic function and diabetes
- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- Infectious Diseases and Mycology
- Orthopedic Infections and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gastrointestinal disorders and treatments
- Cancer and Skin Lesions
Consejo Superior de Investigaciones Científicas
2024
Hospital Universitario Insular de Gran Canaria
1998-2023
Universidad de Las Palmas de Gran Canaria
2001-2023
Universidad de Granada
2019
Hospital La Paloma
2008-2013
Hospital Perpetuo Socorro
2010-2011
Hospital Materno-Infantil
2008
Canary Institute of Cancer Research
2002-2008
Parque Tecnológico de la Salud
2007
Hospital Universitario de Gran Canaria Doctor Negrín
1992-2001
Sleep disturbance is a classic sign of hepatic encephalopathy. However, there are limited data regarding its prevalence in cirrhotic patients without overt We assessed the characteristics sleep cirrhosis using questionnaire (n = 44) and actigraphy 20). The results were compared with those subjects chronic renal failure healthy controls. Presence subclinical encephalopathy, chronotypology profile, individual’s affective state also analyzed. indicated an elevated number (47.7%) (38.6%) who...
The aim of this study was to analyze the outcomes treatment necrotizing soft-tissue infections (NSTIs) in feet diabetic patients and determine factors associated with limb salvage mortality. A retrospective a consecutive series 145 suffering from NSTIs treated Diabetic Foot Unit, La Paloma Hospital done. were classified as cellulitis if it involved subcutaneous tissue skin, fasciitis deep fascia, myonecrosis those cases where muscular necrosis present. In group (n = 109), 8 (7.3%) major...
Eccrine sweat glands (ESGs) are critical for thermoregulation and involved in wound healing. ESGs have traditionally been considered as separate skin appendages without connection to the pilosebaceous unit (PSU). However, recent preliminary evidence has encouraged hypothesis that PSU ESG more interconnected than previously thought. To re‐evaluate morphology of human adnexa with an integrated three‐dimensional (3D) perspective order explore possible interconnections may form. A systematic 3D...
<h3>BACKGROUND</h3> Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, significant inverse correlation between postparacentesis changes activity and systemic vascular resistance has been demonstrated these patients, suggesting that peripheral arterial vasodilatation could be responsible for this dysfunction, but the mechanisms which removal induces such are unknown...
The aim of this study was to compare the outcomes surgical treatment osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) with cases methicillin-sensitive (MSSA).We abstracted data a series 185 consecutive patients diabetes and foot undergoing surgery within first 12 h after admission at single hospital. Bone infection confirmed histopathological studies. Only where isolated from bone specimens were included in analysis. We analysed several variables between two groups:...
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide, but precise intracellular mechanisms underlying progression this inflammation associated cancer are not well established. SOCS2 protein plays an important role in carcinogenesis different tumors by regulating cytokine signalling through JAK/STAT axis. However, its HCC unclear. Here, we investigate potential as biomarker. The effects were evaluated experimental model diethylnitrosamine (DEN)-induced...
The purpose of this study was to analyze the outcomes major lower extremity amputations (MLEAs) in a series, including diabetic patients, with aim whether diabetes mellitus is risk factor in-hospital mortality and perioperative complications. A retrospective analysis 283 MLEAs (221 these patients were 62 nondiabetic) performed between January 1, 1998, December 31, 2008, at General Surgery Department Diabetic Foot Unit La Paloma Hospital Las Palmas de Gran Canaria (Canary Islands) done....
Abstract The high prevalence of antibiotic resistant bacteria (ARB) in several environments is a great concern threatening human health. Particularly, wastewater treatment plants (WWTP) become important contributors to the dissemination ARB receiving water bodies, due inefficient management or highly antibiotic-concentrated wastewaters. Hence, it vital develop molecular tools that allow proper monitoring genes encoding resistances these therapeutic compounds (antibiotic genes, ARGs). For an...
The liver of adult mammals contains various classes polyploid hepatocytes produced by a process that is partially regulated hormones. However, it not well understood how the hormones affect rate hepatocyte proliferation under physiological conditions. Here we have studied specific roles 3,5,3'-triiodothyronine (T3), growth hormone (GH), and sex steroids on percentage diploid nuclei in S phase population tetraploid (4C) cell several rat model systems. Gonadal had no effect but account for...
Fourteen cirrhotic patients with tense ascites were treated total paracentesis and intravenous isotonic saline infusion. Standard liver kidney function tests, plasma renin activity aldosterone concentration measured before, at 48 hrs 7 days after paracentesis. The volume of removed was 7.7 +/- 5.6 l (mean S.E.M.). None the had clinical complications or significant alterations in test results. Paracentesis infusion not associated changes mean concentration. These results suggest that this...
Surgery is usually used to treat diabetic foot osteomyelitis (DFO), whether primarily or in cases which antibiotics are not able control infection. In many cases, the bone only partially removed, means that residual infection remains margins, and wound left open heal by secondary intent. The use of culture-guided postoperative antibiotic treatment adequate management must be addressed. No trials exist dealing with local these complicated DFO. We decided test a super-oxidized solution,...
Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because this, TPO expression may be impaired in selected diseases. The goal this study to analyze immune differentiated cancer, and determine whether has any prognostic value.A total 139 patients who required surgery due nodule with signs or symptoms suspicious malignancy during their physical, ultrasound and/or cytology examination were consecutively study. A immunohistochemical was carried...
Introduction: Coagulase-negative staphylococci are considered as microorganisms with little virulence and usually contaminants. In order to establish the role of Staphylococcus epidermidis a pathogen in diabetic foot osteomyelitis, addition isolation sole bacterium from bone it will be necessary demonstrate histopathological changes caused by infection. Methods: A consecutive series 222 patients osteomyelitis treated surgically Diabetic Foot Unit at La Paloma Hospital (Las Palmas de Gran...
Twenty patients with cirrhosis and ascites but no renal failure were given piretanide, a new loop diuretic, in order to investigate its efficacy relate the diuretic response pretreatment plasma aldosterone concentration. Eleven responded piretanide 12 mg/day (equivalent potency 80 mg furosemide); there was nine patients. Both groups similar regard liver function, urea, serum creatinine, electrolytes, urine volume, potassium The basal urinary sodium excretion significantly higher those who...