A5038354919- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Galectins and Cancer Biology
- Heat shock proteins research
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Protein Tyrosine Phosphatases
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Estrogen and related hormone effects
- Lipoproteins and Cardiovascular Health
- Monoclonal and Polyclonal Antibodies Research
- Macrophage Migration Inhibitory Factor
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Apelin-related biomedical research
- Bioactive Compounds and Antitumor Agents
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
Universidad de Las Palmas de Gran Canaria
2019-2024
University of Oxford
2016-2019
Hospital Universitario Fundación Jiménez Díaz
2012-2018
Universidad Autónoma de Madrid
2014-2018
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2014-2018
Sir Robert McAlpine (United Kingdom)
2017
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2014-2015
Universitat de València
2010
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. activation involved inflammatory response but mechanisms by which it modulates inflammation have incompletely described. In this study, we investigated expression, function macrophages to establish role during response. We observed that murine tissues increased endotoxemia, hyperglycemia hypercholesterolemia. Ex vivo studies revealed mRNA LPS other...
Heat shock proteins (HSPs) are induced by cellular stress and function as molecular chaperones that regulate protein folding. Diabetes impairs the function/expression of many HSPs, including HSP70 HSP90, key regulators pathological mechanisms involved in diabetes complications. Therefore, we investigated whether pharmacological HSP90 inhibition ameliorates diabetes-associated renal damage atheroprogression a mouse model combined hyperglycemia hyperlipidemia (streptozotocin-induced diabetic...
Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand cellular molecular basis actions apoA1, we explored effect acute human apoA1 exposure on migratory capacity monocyte-derived cells in vitro vivo. Acute (20–60 min) treatment induced a substantial (50–90%) reduction macrophage chemotaxis to range chemoattractants. This was vivo as shown by pre-treatment monocytes prior adoptive...
Interactive relationships between metabolism, inflammation, oxidative stress, and autophagy in the vascular system play a key role pathogenesis of diabetic cardiovascular disease. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is stress-sensitive guarantor cellular homeostasis, which cytoprotective contributions extend beyond antioxidant defense. We investigated beneficial effects underlying mechanisms Nrf2 inducer tert-butyl hydroquinone (tBHQ) on diabetes-driven atherosclerosis. In...
Activation of Janus kinase/signal transducers and activators transcription (STAT) pathway by hyperglycemia dislypidemia contributes to the progression diabetic complications, including atherosclerosis. Suppressor cytokine signaling (SOCS) proteins negatively regulate kinase/STAT have emerged as promising target for anti-inflammatory therapies. We investigated whether a cell-permeable lipopeptide corresponding kinase inhibitory region SOCS1 could reduce atherosclerosis in mice identified...
Diabetes is the main cause of CKD and ESRD worldwide. Chronic activation Janus kinase signal transducer activator transcription (STAT) signaling contributes to diabetic nephropathy by inducing genes involved in leukocyte infiltration, cell proliferation, extracellular matrix accumulation. This study examined whether a cell-permeable peptide mimicking kinase-inhibitory region suppressor cytokine signaling-1 (SOCS1) regulatory protein protects against suppressing STAT-mediated responses...
Among patients with diabetes, increased production of immunoglobulins against proteins modified by diabetes is associated proteinuria and cardiovascular risk, suggesting that immune mechanisms may contribute to the development complications, such as nephropathy. We investigated contribution IgG Fcγ receptors diabetic renal injury in hyperglycemic, hypercholesterolemic mice. used streptozotocin induce apolipoprotein E-deficient mice deficient both E γ-chain, common subunit activating...
GPR84 is an orphan G-protein-coupled receptor that expressed on immune cells and implicated in several inflammatory diseases. The validation of as a therapeutic target hindered by the narrow range available chemical tools consequent poor understanding pathophysiology. Here we describe discovery characterization DL-175, potent, selective, structurally novel agonist first to display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, human U937 cells....
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide, but precise intracellular mechanisms underlying progression this inflammation associated cancer are not well established. SOCS2 protein plays an important role in carcinogenesis different tumors by regulating cytokine signalling through JAK/STAT axis. However, its HCC unclear. Here, we investigate potential as biomarker. The effects were evaluated experimental model diethylnitrosamine (DEN)-induced...
Macrophages are key cells in both acute and chronic inflammatory settings. Their activation function highly depends on the cytokines, chemokines adhesion molecules that direct monocytes to infiltrate tissues, differentiate into macrophages, finally lead clearance of such signals. Galectins, β‐galactoside‐binding lectins, differentially expressed by various immune cells, some members this family have been identified as regulators leukocyte recruitment activation. Galectin-1 (Gal-1) galectin-9...
Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients. We hypothesize that Fcγ receptors for IgG constant region participate atherogenesis regulating the inflammatory state of lesional macrophages. In vivo we examined role activating atherosclerosis progression using bone marrow transplantation from mice deficient γ-chain (the...
Chemerin is a chemotactic protein that induces migration of several immune cells including macrophages, immature dendritic and NK cells. binds to three G protein-coupled receptors (GPCRs), CCRL2. The exact function CCRL2 remains unclear. Ccrl2 expression rapidly upregulated during inflammation, but it lacks the intracellular DRYLAIV motif required for classical GPCR downstream signalling pathways has not been reported internalise chemerin upon binding. aim this study was investigate what...
The endocannabinoid system consists of endogenous lipid mediators and cannabinoid receptors (CB) 1 2. It has previously been demonstrated that activation the leukocyte-expressed CB2 anti-inflammatory effects in vivo. Here, we report its role under baseline conditions a model low-dose endotoxemia by comparing knockout to littermate control mice. CB2-deficient mice displayed significantly more neutrophils fewer monocytes bone marrow steady state. In initial validation experiments,...
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling catabolism of surfactant material, a lipid/protein fluid essential for respiratory function. The liver X receptors (LXR), LXRα LXRβ, are transcription factors important lipid metabolism inflammation. While LXR activation exerts anti-inflammatory actions lung injury caused by lipopolysaccharide (LPS) other inflammatory stimuli, full extent endogenous transcriptional activity pulmonary...