A5077591484- Cardiac electrophysiology and arrhythmias
- Angiogenesis and VEGF in Cancer
- Photoacoustic and Ultrasonic Imaging
- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Thermoregulation and physiological responses
- Advanced MEMS and NEMS Technologies
- Cerebrovascular and Carotid Artery Diseases
- Environmental Quality and Pollution
- Pancreatic and Hepatic Oncology Research
- Wound Healing and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neural Engineering
- Lymphatic System and Diseases
- Soil Carbon and Nitrogen Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Structural Anomalies and Repair
- Receptor Mechanisms and Signaling
- Magneto-Optical Properties and Applications
- Skin Protection and Aging
- Barrier Structure and Function Studies
- Analog and Mixed-Signal Circuit Design
- Cell Adhesion Molecules Research
- PARP inhibition in cancer therapy
- Geochemistry and Geologic Mapping
Stanford University
2023-2024
ETH Zurich
1995-2019
University of Zurich
2019
Institute for Biomedical Engineering
2019
Novartis (Switzerland)
2013
Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and pathogenesis tumor progression. We investigated innervation LVs response to agonists antagonists autonomic nervous system vivo. While skin-draining collecting express muscarinic, α1- β2-adrenergic receptors on lymphatic endothelial cells smooth muscle cells, intestinal lacteals only β-adrenergic muscarinic their cells. Quantitative vivo near-infrared imaging exposed flank-collecting LV revealed that...
Abstract Angiogenesis during wound healing is essential for tissue repair and also affected cancer treatment by anti-angiogenic drugs. Here, we introduce a minimally invasive model in the mouse ear to assess angiogenesis with high spatiotemporal resolution longitudinal manner vivo using two-photon microscopy mice expressing GCaMP2 arterial endothelial cells. The development of vascular sprouts occurred highly orchestrated within time window 8 days following wounding. Novel developed...
Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) azithromycin (AZM) were used as a combination therapy in the treatment COVID-19 patients at beginning pandemic, leading to higher complication rates comparison respective monotherapies. Here, we human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) systematically investigate HCQ, AZM, on structure functionality...
Molecular imaging using positron emission tomography (PET) provides sensitive detection and mapping of molecular targets. While cancer-associated fibroblasts integrins have been proposed as targets for pancreatic ductal adenocarcinoma (PDAC), herein, spatial transcriptomics proteomics human surgical samples are applied to select PDAC We find that selected cancer cell surface markers spatially correlated provide specific localization, whereas the correlation between immune-related or...
Abstract Despite known adverse effects of hydroxychloroquine (HCQ) and azithromycin (AZM) on cardiac function, HCQ AZM have been used as combination therapy in the treatment COVID-19 patients. Recent clinical data indicate higher complication rates with HCQ/AZM comparison to monotherapy. Here, we human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) systematically investigate individually combination. The clinically observed QT prolongation caused by could be recapitulated...
Atherosclerosis is an inflammatory process resulting in the deposition of cholesterol and cellular debris, narrowing vessel lumen clot formation. Characterization morphology vulnerability lesion essential for effective clinical management. Photoacoustic imaging has sufficient penetration sensitivity to map characterize human atherosclerotic plaque. Here, near infrared photoacoustic shown detect plaque components and, when combined with ultrasound imaging, differentiate stable vulnerable In...