A5068265574- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Advanced NMR Techniques and Applications
- Cardiac Imaging and Diagnostics
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Mitochondrial Function and Pathology
- Atomic and Subatomic Physics Research
- Brain Tumor Detection and Classification
- Diet and metabolism studies
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- AI in cancer detection
- Liver Disease and Transplantation
- Bone and Joint Diseases
- Ultrasound Imaging and Elastography
- Hematological disorders and diagnostics
- Radiation Dose and Imaging
- NMR spectroscopy and applications
- Advanced X-ray and CT Imaging
University of Minnesota
2016-2025
Resonance Research (United States)
2014-2024
University Hospital Heidelberg
2024
Johns Hopkins University
2024
Fred Hutch Cancer Center
2024
University of California, San Francisco
2024
University of Maryland, Baltimore
2024
Sidney Kimmel Comprehensive Cancer Center
2024
Cancer Research Center
2024
University of Washington
2024
Purpose To determine if the change in tumor apparent diffusion coefficient (ADC) at diffusion-weighted (DW) MRI is predictive of pathologic complete response (pCR) to neoadjuvant chemotherapy for breast cancer. Materials and Methods In this prospective multicenter study, 272 consecutive women with cancer were enrolled 10 institutions (from August 2012 January 2015) randomized treatment 12 weekly doses paclitaxel (with or without an experimental agent), followed by weeks four cycles...
To determine if changes in the concentration of choline-containing compounds (tCho) from before primary systemic therapy (PST) to within 24 hours after first treatment enable prediction clinical response patients with locally advanced breast cancer.Sixteen women biopsy-confirmed cancer scheduled undergo doxorubicin-based PST were recruited. Magnetic resonance (MR) imaging and spectroscopy performed at 4 T prior treatment, dose, fourth dose. Lesion size was assessed by using...
Abstract The objective of this study was to investigate the feasibility whole‐body imaging at 7T. To achieve objective, new technology and methods were developed. Radio frequency (RF) field distribution specific absorption rate (SAR) first explored through numerical modeling. A body coil then designed built. Multichannel transmit receive coils also developed implemented. With in hand, an survey “landscape” human 7T conducted. Cardiac appeared be possible. potential for breast spectroscopy...
Abstract This work describes a methodology for quantifying levels of total choline‐containing compounds (tCho) in the breast using vivo 1 H MR spectroscopy (MRS) at high field (4 Tesla). Water is used as an internal reference compound to account partial volume adipose tissue. Peak amplitudes are estimated by fitting one peak time over narrow frequency band allow measurement small metabolite resonances spectra with large lipid peaks. quantitative method significantly improves previously...
Quantitative diffusion-weighted imaging (DWI) MRI is a promising technique for cancer characterization and treatment monitoring. Knowledge of the reproducibility DWI metrics in breast tumors necessary to apply as clinical biomarker. To evaluate repeatability tumor apparent diffusion coefficient (ADC) multi-institution trial setting, using standardized protocols quality assurance (QA) procedures. Prospective. In all, 89 women from nine institutions undergoing neoadjuvant chemotherapy invasive...
Stress-associated conditions such as psychoemotional reactivity and depression have been paradoxically linked to either weight gain or loss. This bi-directional effect of stress is not understood at the functional level. Here we tested hypothesis that pre-stress level adaptive thermogenesis brown adipose tissue (BAT) functions explain vulnerability resilience stress-induced obesity.
Purpose To describe the design, conduct, and results of Breast Multiparametric MRI for prediction neoadjuvant chemotherapy Response (BMMR2) challenge. Materials Methods The BMMR2 computational challenge opened on May 28, 2021, closed December 21, 2021. goal was to identify image-based markers derived from multiparametric breast MRI, including diffusion-weighted imaging (DWI) dynamic contrast-enhanced (DCE) along with clinical data predicting pathologic complete response (pCR) following...
Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted (UE) on weight, body composition, intake, glycemic measures, metabolic flexibility. In this 12-week randomized-controlled trial, we measured (primary outcome), composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), intake (24-h recall), flexibility (indirect calorimetry during hyperinsulinemic-euglycemic...
PURPOSE: To determine whether the addition of in vivo quantitative hydrogen 1 (1H) magnetic resonance (MR) spectroscopy can improve radiologist's diagnostic accuracy interpreting breast MR images to distinguish benign from malignant lesions. MATERIALS AND METHODS: The study was approved by institutional review board and, where appropriate, compliant with Health Insurance Portability and Accountability Act. All patients provided written informed consent. Fifty-five imaging cases—one lesion...
Purpose To assess the feasibility of using fat‐fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy. Materials and Methods Thirteen women with gynecologic malignancies who were to receive radiation and/or chemotherapy recruited this study. Subjects imaged on a 3T magnetic resonance (MR) scanner at baseline (after surgery but before or chemotherapy), 6 months, 12 months after treatment. Water–fat was used generate high‐resolution,...
Abstract Dynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). The purpose of this retrospective study is test if prediction models combining multiple features outperform with single features. Four were quantitatively calculated in each exam: volume, longest diameter, sphericity, contralateral background parenchymal enhancement. Logistic regression analysis was used the relationship...
To improve the ability to move from preclinical trials in mouse models of Huntington's disease (HD) clinical humans, biomarkers are needed that can track similar aspects progression across species. Brain metabolites, detectable by magnetic resonance spectroscopy (MRS), have been suggested as potential HD. In this study, R6/2 transgenic model HD was used investigate relative sensitivity metabolite profiling and brain volumetry anticipate progression. Magnetic imaging (MRI) 1 H MRS data were...
Purpose To develop multiparametric magnetic resonance (MR) imaging models to generate a quantitative, user-independent, voxel-wise composite biomarker score (CBS) for detection of prostate cancer by using coregistered correlative histopathologic results, and compare performance CBS-based with that single quantitative MR parameters. Materials Methods Institutional review board approval informed consent were obtained. Patients diagnosis underwent before surgery treatment. All voxels in the...
Purpose To estimate the accuracy of predicting response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer using MR spectroscopy (MRS) measurements made very early treatment. Materials and Methods This prospective Health Insurance Portability Accountability Act (HIPAA)–compliant protocol was approved by American College Radiology local-site institutional review boards. One hundred nineteen women invasive ≥3 cm undergoing NACT were enrolled between September...
Abstract Detecting metabolites in breast lesions by vivo 1 H MR spectroscopy can be difficult due to the abundance of mobile lipids which produce spurious sidebands that interfere with metabolite signals. Two‐dimensional J ‐resolved has been demonstrated brain as a means eliminate these artifacts from large water signal; coherent are resolved at their natural frequencies, leaving noncoupled resonances zero‐frequency trace 2D spectrum. This work demonstrates using trace—or equivalently...
Abstract Eight‐ and sixteen‐channel transceive stripline/TEM body arrays were compared at 7 T (297 MHz) both in simulation experiment. Despite previous demonstrations of similar for use applications, a quantitative comparison the two configurations has not been undertaken to date. Results obtained on male pelvis assessing transmit, signal noise ratio, parallel imaging performance evaluate local power deposition versus transmit B 1 ( + ). All measurements simulations conducted after...
Background Diffusion-weighted imaging (DWI) shows promise in detecting and monitoring breast cancer, but standard spin-echo (SE) echo-planar DWI methods often have poor image quality low spatial resolution. Proposed alternatives include readout-segmented (RS) axially reformatted (AR)-simultaneous multislice (SMS) imaging. Purpose To compare the resolution of SE with two high-spatial-resolution alternatives, RS AR-SMS imaging, for Materials Methods In a prospective study (2016-2018), three...
Abstract Respiratory motion is well known to cause artifacts in magnetic resonance spectroscopy (MRS). In MRS of the breast, dominant artifact not due breast itself, but rather it produced by B 0 field distortions associated with respiratory tissues chest and abdomen. This susceptibility has been reported occur brain, more apparent anatomic proximity lungs. these shot‐to‐shot frequency shifts, which vary an average 24 Hz during a typical 1 H scan at 4 T. variation can be corrected...