A5101765349- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Legume Nitrogen Fixing Symbiosis
- Glioma Diagnosis and Treatment
- Plant Reproductive Biology
- Cancer Research and Treatments
- Protist diversity and phylogeny
- Nematode management and characterization studies
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
Fujian Agriculture and Forestry University
2016-2019
The University of Kansas Cancer Center
2011-2013
University of Kansas Medical Center
2011-2013
University of Kansas
2012
Activation of the sonic hedgehog (SHh) pathway is required for growth numerous tissues and organs recent evidence indicates that this often recruited to stimulate cancer stem cells (CSCs) orchestrate reprogramming via epithelial mesenchymal transition (EMT). The objectives study were examine molecular mechanisms by which (-)-epigallocatechin-3-gallate (EGCG), an active compound in green tea, inhibits self-renewal capacity pancreatic CSCs synergizes with quercetin, a major polyphenol...
Recent evidence from in vitro and vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway regulates genes promote cellular proliferation various human cancer stem cells (CSCs). Therefore, chemotherapeutic agents inhibit activation Gli transcription factors have emerged as promising novel therapeutic drugs for pancreatic cancer. GDC-0449 (Vismodegib), orally administrable molecule belonging to 2-arylpyridine class, inhibits SHH by blocking...
Dysregulation of the sonic hedgehog (Shh) signaling pathway has been associated with cancer stem cells (CSC) and implicated in initiation pancreatic cancer. Pancreatic CSCs are rare tumor characterized by their ability to self-renew, responsible for recurrence accompanied resistance current therapies. The lethality these incurable, aggressive invasive tumors remains a daunting clinical challenge. Thus, objective this study was investigate role Shh examine molecular mechanisms which...
Glioblastoma multiforme is the most common form of primary brain tumor, often characterized by poor survival. initiating cells (GICs) regulate self-renewal, differentiation, and tumor initiation properties are involved in growth, recurrence, resistance to conventional treatments. The sonic hedgehog (SHH) signaling pathway essential for normal development embryonic morphogenesis. objectives this study were examine molecular mechanisms which GIC characteristics regulated NPV-LDE-225...
Trans‑3,4',5‑trihydroxystilbene (resveratrol) is a naturally occurring polyphenolic phytoalexin with marked anticancer activities, and mainly found in grapes, berries peanuts. However, due to low bioavailability, it has not progressed clinical practice for cancer treatment. Therefore, the aims of present study were examine activities resveratrol derivative, triacetyl (TCRV), pancreatic cells. Apoptosis was measured by fluorescence‑activated cell sorting terminal deoxynucleotidyl transferase...
Abstract Aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway promotes prostate cancer (PC) growth and progression by regulating cancer‐related genes through its downstream effectors GLI1 GLI2. Therefore, targeting SHH‐GLI provides an alternative approach to avoid progression. The aim this study was delineate underlying molecular mechanisms which GDC‐0449 (a SMO receptor inhibitor) GANT‐61 GLI transcription factor regulate cellular proliferation self‐renewal in human PC stem...
Abstract Volvariella volvacea is an important crop in Southeast Asia, but erratic fruiting presents a serious challenge for its production and breeding. Efforts to explain inconsistent have been complicated by the multinucleate nature, typical lack of clamp connections, incompletely identified sexual reproductive system. In this study, we addressed life cycle V. using whole genome sequencing, cloning MAT loci, karyotyping spores, assays. Microscopy analysis spores had previously indicated...
Abstract The existence of cancer stem cells (CSCs) in prostate has profound implications for prevention and/or treatment. CSC population resides within the tumor mass and they may be responsible drug resistance, recurrence cancer. Therefore, development novel strategies to target CSCs by nontoxic agent resveratrol is an innovative idea management Activation Wnt, sonic hedgehog (Shh) Notch pathways are required growth numerous tissues organs recent evidence indicates that these often...
Abstract Multiple lines of evidence suggest that the Sonic Hedgehog (Shh) signaling pathway is aberrantly reactivated in pancreatic cancer stem cells (CSCs). The objectives this study were to examine molecular mechanisms by which GANT-61 (Gli transcription factor inhibitor) regulates cell characteristics and tumor growth. Effects on CSC's viability, spheroid formation, apoptosis, DNA-binding transcriptional activities, epithelial-mesenchymal transition (EMT) measured. Humanized...