A5000724742- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cannabis and Cannabinoid Research
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
Goethe University Frankfurt
2022-2025
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members FAM134 family play a critical role stress-induced ER-phagy. However, mechanisms on how they are activated remain largely unknown. In this study, we analyze phosphorylation trigger FAM134-driven ER-phagy upon mTOR (mechanistic target rapamycin) inhibition. An unbiased...
Autophagy facilitates the degradation of cellular content via lysosome and is involved in homeostasis stress response pathways. As such, malfunction autophagy linked to a variety diseases ranging from organ-specific illnesses like cardiomyopathy systemic such as cancer or metabolic syndromes. Given autophagic functions within cell tissue, regulation complex contains numerous positive negative feedback loops. While our knowledge mechanisms for cargo selectivity has significantly improved over...
Recent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology other mechanisms, including autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) received considerable attention from drug development community. ATTECs are based on recruitment targets LC3/GABARAP, a family ubiquitin-like proteins presumably bind membrane and tether cargo-loaded autophagy receptors into...
Summary Autophagy-lysosomal impairment is an early and prominent feature of neurodegeneration. Autophagy activation reduces protein aggregates lipid level abnormalities. We performed a high-content imaging-based screen assessing 940,000 small molecules to identify those that reduce droplet numbers. Of 77 validated, structurally diverse hits, 24 increased autophagy flux reporter activity, consistent with accelerated clearance by lipophagy. these, we show CCT020312 activates independently...
Abstract Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members FAM134 family play a critical role stress-induced ER-phagy. However, mechanisms on how they are activated remain largely unknown. In this study, we analyzed phosphorylation trigger FAM134-driven ER-phagy upon mTOR (mechanistic target rapamycin) inhibition. An...