A5039960024- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Molecular Spectroscopy and Structure
- Radical Photochemical Reactions
- Carbohydrate Chemistry and Synthesis
- Inorganic Fluorides and Related Compounds
- Autophagy in Disease and Therapy
- Photochemistry and Electron Transfer Studies
- Endoplasmic Reticulum Stress and Disease
- Synthesis and properties of polymers
- Cellular transport and secretion
- Advanced Chemical Physics Studies
- Nonlinear Optical Materials Research
- RNA and protein synthesis mechanisms
- Transgenic Plants and Applications
- Fluorine in Organic Chemistry
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
Scripps Research Institute
2015-2023
Amherst College
2016-2021
Scripps (United States)
2019
Torrey Pines Institute For Molecular Studies
2019
Scripps Institution of Oceanography
2019
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although provides access libraries unprecedented size diversity, the idiosyncratic hydrophilic nature tag severely limits scope applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed eluted from solid supports, this phenomenon been utilized...
Abstract Tyrosine O‐sulfation is a common protein post‐translational modification that regulates many biological processes, including leukocyte adhesion and chemotaxis. Many peptides with therapeutic potential contain one or more sulfotyrosine residues. We report one‐step synthesis for Fmoc‐fluorosulfated tyrosine. An efficient Fmoc‐based solid‐phase peptide synthetic strategy then introduced incorporating the fluorosulfated tyrosine residue into of interest. Standard simultaneous...
Abstract Tyrosine O‐sulfation is a common protein post‐translational modification that regulates many biological processes, including leukocyte adhesion and chemotaxis. Many peptides with therapeutic potential contain one or more sulfotyrosine residues. We report one‐step synthesis for Fmoc‐fluorosulfated tyrosine. An efficient Fmoc‐based solid‐phase peptide synthetic strategy then introduced incorporating the fluorosulfated tyrosine residue into of interest. Standard simultaneous...
Pharmacological activation of the activating transcription factor 6 (ATF6) arm unfolded protein response (UPR) has proven useful for ameliorating proteostasis deficiencies in cellular and mouse models numerous etiologically diverse diseases. Previous high-throughput screening efforts identified small molecule AA147 as a potent selective ATF6 compound that operates through mechanism involving metabolic its 2-amino-p-cresol substructure affording quinone methide, which then covalently modifies...
Summary Autophagy-lysosomal impairment is an early and prominent feature of neurodegeneration. Autophagy activation reduces protein aggregates lipid level abnormalities. We performed a high-content imaging-based screen assessing 940,000 small molecules to identify those that reduce droplet numbers. Of 77 validated, structurally diverse hits, 24 increased autophagy flux reporter activity, consistent with accelerated clearance by lipophagy. these, we show CCT020312 activates independently...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp<sup>2</sup>)-C(sp<sup>3</sup>) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp 2 )-C(sp 3 ) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and improved reductive conditions. We believe that...