A5040235016- Obesity, Physical Activity, Diet
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Physical Activity and Health
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Cardiovascular and exercise physiology
- Crystallization and Solubility Studies
- Exercise and Physiological Responses
- X-ray Diffraction in Crystallography
- Eating Disorders and Behaviors
- Nutrition, Genetics, and Disease
- Genetics and Physical Performance
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Health and Lifestyle Studies
- Diet, Metabolism, and Disease
- DNA and Nucleic Acid Chemistry
- Radical Photochemical Reactions
- Pharmacology and Obesity Treatment
- Bee Products Chemical Analysis
- Metabolism and Genetic Disorders
- Click Chemistry and Applications
- Crystallography and molecular interactions
- High Altitude and Hypoxia
Scripps Institution of Oceanography
2020
Torrey Pines Institute For Molecular Studies
2020
Texas A&M University
2012-2018
San Jose State University
2017
University of Michigan
2007-2008
Harvard University
2007
Boston Children's Hospital
2007
Boston University
2007
VA Boston Healthcare System
2007
This study investigated associations between neighborhood physical and social environments body mass index in 2,865 participants of the Multi-Ethnic Study Atherosclerosis (MESA) aged 45–84 years residing Maryland, New York, North Carolina. Neighborhood (census tract) were measured non-MESA MESA neighborhoods (2000–2002). The environment score combined measures a better walking greater availability healthy foods. aesthetic quality, safety, cohesion less violent crime. Marginal maximum...
While commercial dietary weight-loss programs typically advise exercise, few provide actual programing. The goal of this study was to compare the Curves Complete 90-day Challenge (CC, n = 29), which incorporates exercising and diet, advocating exercise (Weight Watchers Points Plus (WW, Jenny Craig At Home (JC, 27), Nutrisystem Advance Select (NS, 28)) or control (n 20) on metabolic syndrome (MetS) weight loss. We randomized 133 sedentary, overweight women (age, 47 ± 11 years; body mass, 86...
Cattle grazing St. Augustine grass growing on peaty muck soils in the Florida Everglades developed anemia associated with presence of Heinz bodies and suboptimal concentrations selenium blood. Selenium supplementation corrected anemia, prevented body formation, increased weight cows calves, elevated blood selenium. This may be first recorded example widespread a population due to deficiency.
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men women ingested placebo (PLA), 3 g of creatine nitrate (CNL), 6 (CNH) for days. Participants repeated the experiment with alternate supplements after 7-day washout. Hemodynamic responses to postural challenge, fasting blood samples, bench press, leg cycling time trial performance recovery were assessed. Data analyzed by univariate, multivariate, measures general linear models (GLM). No significant differences found...
Genetics contribute to variability in individual response weight-loss interventions. The objective of this study was determine the efficacy a commercially available exercise and program whether alignment diet genotype related lipid metabolism promotes greater success.Sedentary women with obesity (n = 63) had (FABP2rs1799883, PPARG2rs1801282, ADRB3rs4994C3, ADRB2rs1042713, rs1042714) determined using direct-to-consumer genetic screening kit purported promote success through dietary...
Keywords: Body CompositionWeight Loss ProgramHigh Protein DietPeak Oxygen UptakeBody Composition Measure
Objective Commercial weight loss programs offer consumers a pre‐programmed means of managing weight. However, such differ in dietary advice and physical activity recommendations. The aim this investigation was compare the Curves ® Complete 90‐day Challenge (CC), Weight Watchers Points Plus (WW), Jenny Craig At Home (JC), Nutrisystem Advance Select™ (NS) on metabolic syndrome (MetS) loss. Methods We examined 133 sedentary overweight women (47±11 yr, 86±14 kg, 35.4±6 kg/m 2 ) randomized into...
Background A number of nutritional strategies have been developed to optimize nutrient delivery prior exercise. As a result, pre-workout supplements increase energy availability, promote vasodilation, and/ or positively affect exercise capacity. The purpose this study was examine the acute effects ingesting preworkout dietary supplement with and without synephrine on cognitive function, perceptions readiness perform, performance.
The controlled, site-specific ligation of molecules to native DNA remains an unanswered challenge. Herein, we report a simple solution achieve this through the tactical combination two recently developed technologies: One for manipulation in organic media, and another chemoselective labeling alcohols. Reversible Adsorption Solid Support (RASS) is employed immobilize facilitate its transfer into dry acetonitrile. Subsequent with P(V)-based Ψ reagents takes place high yield exquisite...
Enantioenriched <i>α</i>-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks organic synthesis. Recently, CuH-catalyzed asymmetric alkene hydrofunctionalization has become powerful tool to construct stereogenic carbon centers. In contrast, applying CuH cascade catalysis achieve reductive 1,1-difunctionalization of alkynes remains...
Background: Monitoring of uric acid levels is significant importance for the prevention conditions such as gout and kidney disease. Likewise, metabolites produced from reaction with reactive oxygen species are indicative level oxidative stress. Quantitative methods therefore needed measuring these compounds in biological sample matrices. Keywords: 6-aminouracil, allantoin, aqueous normal phase, diol, hyperuricemia, silica hydride, acid.
Keywords: Resistance TrainingExercise ProgramBone Mineral ContentWeight Loss ProgramPeak Oxygen Uptake
Background Consumption of tart cherry juice has been reported to effectively reduce inflammation, muscle damage, and soreness following bouts exercise. The purpose this study was determine if consumption a powdered form cherries derived from skins prior intense endurance exercise promotes similar positive results as seen with consumption.
Keywords: CaffeineRespiratory Exchange RatioRest Energy ExpenditureRepeated Measure MANOVABeta Alanine
41 sedentary women (55.6±10 yr, 45.0±4% body fat, 33.7±5 kg/m2) were randomized to participate in a control group (C) or the Curves Complete® (CC) weight loss and circuit resistance‐exercise program for 12‐wks. Participants CC followed an energy‐restricted diet (30% C, 45% P, 25% F) while participating resistance‐training (3 d/wk) walking (30 min, 3/d wk) program. Fasting blood samples obtained at 0, 4, 8, & 12 wks analyzed by MANOVA. Data are presented as changes from baseline after C...
This study examined whether genotype of some obesity‐related genes (FABP2, PPARG, ADRB2‐79, ADRB2‐46, ADRB3) influences success to different diets while participating in an exercise program. 40 sedentary women (41±13 yrs, 35.8±7.9 kg/m 2 ) were matched according genotypes favoring carbohydrate restricted and less diets. Diets 1,500 kcal/d with 20:35:45 30:25:45 percentages C:F:P. Participants performed a circuit style resistance‐exercise program (4 d/wk) walking (10,000 steps/d, 3 d/wk)....
PURPOSE: As part of a 7-d safety study, we examined the short-term dietary pre-workout supplement (PWS) at difference doses on strength and Wingate anaerobic capacity as secondary outcome. METHODS: We recruited 19 apparently healthy recreationally active men women (21.8±2.1 yr, 21.6±8.7 %fat, 26.9±3.8 kg/m2) with least 6-months resistance training, to participate in double-blind, crossover, randomized placebo-controlled manner. instructed subjects maintain their current diet training...
125 sedentary women (46±12 yr, 45.5±5% body fat, 35.0±5 kg/m2) were randomized to participate in a control group (C) or Curves Complete® (CC), Weight Watchers® (WW), Jenny Craig® (JC), Nutrisystem® (NS) weight loss programs for 12‐ wks. Participants the diet groups encouraged exercise (WW, JC, NS) while those CC participated structured program. Data analyzed by MANOVA ANOVA and are presented as changes from baseline after 12‐wks. had greater waist (C 2.1±6.9; −4.7±3.2; WW −4.1±5.7; JC...
100 sedentary women (46±11 yr, 45.8±5% body fat, 35.2±5 kg/m2) were randomized to participate in a no diet or exercise control group (C) the Curves Complete® 90‐day Challenge (CC), Weight Watchers® Points Plus (WW), Jenny Craig® (JC), Nutrisystem® Advance Select™ (NS) weight loss programs for 12‐wks. Participants groups encouraged (WW, JC, NS) while those CC participated structured circuit‐style resistance training (3 d/wk) and walking program. Fasting blood samples obtained at 0, 4, 8,...
ISEE-551 Objective: The delta-aminolevulinic acid dehydratase (ALAD) polymorphism has been shown in some studies to alter the impact of lead on kidney function and other health outcomes, which may be due associated effects binding tissue distribution kinetics. We evaluated modifying influence ALAD interrelations between erythrocyte lead, urine bone interaction with association plasma among older community-exposed men. Materials Methods: Information genotype, levels blood, (measured using...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp<sup>2</sup>)-C(sp<sup>3</sup>) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and...
Herein, we present the adaptation of reversible adsorption to solid support (RASS) for a DEL setting, which allows reactions be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities DEL. The RASS approach enabled rapid development C(sp 2 )-C(sp 3 ) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first synthetic transformation context), and improved reductive conditions. We believe that...
The controlled, site-specific ligation of molecules to native DNA remains an unanswered challenge. Herein, we report a simple solution achieve this through the tactical combination two recently developed technologies: One for manipulation in organic media, and another chemoselective labeling alcohols. Reversible Adsorption Solid Support (RASS) is employed immobilize facilitate its transfer into dry acetonitrile. Subsequent with P(V)-based Ψ reagents takes place high yield exquisite...
The purpose of this study was to examine the relationship responses a carbohydrate intolerance (CI) questionnaire body composition and markers health. 108 women (31.6±13 yrs, 34.7±7% fat, BMI 25.3±4) donated fasting blood samples, completed CI survey, had health measures determined, underwent 75g, 2‐h OGTT. Pearson product correlations were performed determine questions. Being more than 25 lbs overweight correlated with OGTT G90 (r=0.22), G120 (r=0.25), glucose AUMC (r=0.19), age (r=0.43),...
The OGTT is a gold standard in assessing carbohydrate intolerance (CI) and insulin resistance. However, the test costly time consuming. This study examined whether responses to survey could predict response an OGTT. 108 women (31.6±13 yrs, 34.7±7% body fat, 25.3±4 kg/m2) donated fasting blood samples, completed CI inventory, had composition health measures determined, underwent 75g, 2‐hr Pearson product correlations were performed determine which factors correlated with glucose at 120...