A5048148127- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- interferon and immune responses
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Cannabis and Cannabinoid Research
- Cellular transport and secretion
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Sirtuins and Resveratrol in Medicine
- Glycosylation and Glycoproteins Research
University of Regensburg
2020-2024
Goethe University Frankfurt
2023
ETH Zurich
2019
Abstract Circular RNAs (circRNAs) encompass a widespread and conserved class of RNAs, which are generated by back-splicing downstream 5′ to upstream 3′ splice sites. CircRNAs tissue-specific have been implicated in diseases including cancer. They can function as sponges for microRNAs (miRNAs) or RNA binding proteins (RBPs), example. Moreover, some contain open reading frames (ORFs) might be translated. The functional relevance such peptides, however, remains largely elusive. Here, we report...
The Mediator kinase module regulates eukaryotic transcription by phosphorylating transcription-related targets and modulating the association of RNA polymerase II. activity its catalytic core, cyclin-dependent 8 (CDK8), is controlled Cyclin C regulatory subunit MED12, with deregulation contributing to numerous malignancies. Here, we combine in vitro biochemistry, cross-linking coupled mass spectrometry, vivo studies describe binding location N-terminal segment MED12 on CDK8/Cyclin complex...
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members FAM134 family play a critical role stress-induced ER-phagy. However, mechanisms on how they are activated remain largely unknown. In this study, we analyze phosphorylation trigger FAM134-driven ER-phagy upon mTOR (mechanistic target rapamycin) inhibition. An unbiased...
Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- nonsense mutations in the gene encoding for Tectonin β-propeller repeat containing protein 2 (TECPR2). While TECPR2 required lysosomal consumption of autophagosomes ER-to-Golgi transport, it remains elusive how exactly involved autophagy secretion what downstream sequels arise from defective due to its involvement these processes. To address questions, we determine molecular consequences...
Understanding the molecular signatures of colorectal cancer progression under chemotherapeutic treatment will be crucial for success future therapy improvements. Here, we used a xenograft-based mouse model to investigate, how whole transcriptome change during metastatic and such are affected by LDM chemotherapy using RNA sequencing. We characterized mRNAs as well non-coding RNAs microRNAs, long circular in colorectal-cancer bearing mice with or without chemotherapy. Furthermore, found that...
Vascular smooth muscle cells (SMCs) can transition between a quiescent contractile or "differentiated" phenotype and "proliferative-dedifferentiated" in response to environmental cues, similar what occurs the wound healing process observed fibroblasts. When dysregulated, these processes contribute development of various lung cardiovascular diseases such as Chronic Obstructive Pulmonary Disease (COPD). Long non-coding RNAs (lncRNAs) have emerged key modulators SMC differentiation phenotypic...
Abstract Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members FAM134 family play a critical role stress-induced ER-phagy. However, mechanisms on how they are activated remain largely unknown. In this study, we analyzed phosphorylation trigger FAM134-driven ER-phagy upon mTOR (mechanistic target rapamycin) inhibition. An...