Mehmet Gökhan Çağlayan

ORCID: 0000-0002-4212-3549
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Research Areas
  • Analytical Methods in Pharmaceuticals
  • Advanced biosensing and bioanalysis techniques
  • Biosensors and Analytical Detection
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Spondyloarthritis Studies and Treatments
  • Electrochemical Analysis and Applications
  • Molecular Sensors and Ion Detection
  • Analytical Chemistry and Chromatography
  • Autoimmune and Inflammatory Disorders Research
  • Antibiotics Pharmacokinetics and Efficacy
  • Analytical Chemistry and Sensors
  • Connective tissue disorders research
  • Pregnancy-related medical research
  • Electrochemical sensors and biosensors
  • Microfluidic and Capillary Electrophoresis Applications
  • Forensic Toxicology and Drug Analysis
  • Reproductive System and Pregnancy
  • S100 Proteins and Annexins
  • Musculoskeletal pain and rehabilitation
  • Stroke Rehabilitation and Recovery
  • Peptidase Inhibition and Analysis
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Protein Interaction Studies and Fluorescence Analysis
  • Rheumatoid Arthritis Research and Therapies
  • Neuropeptides and Animal Physiology

Ankara University
2014-2024

Dicle University
2013-2023

Bowling Green State University
2015-2017

Diyarbakır Askeri Hastanesi
2014

Objective: Stroke does not only affect the physical state of patients but also emotional their relatives, most effectively caregivers. The study aims to examine mood caregivers experienced with care for stroke who are highly dependent on assistance and establish relationship between severity disability patients.Methods: This contained a total 76 sufficient cognitive functions severe disabilities hemiplegia caused by cerebrovascular accident 94 controls. functional was assessed Barthel Index...

10.1080/10749357.2017.1280901 article EN Topics in Stroke Rehabilitation 2017-03-20

Background Calprotectin is one of the major leukocyte S100 proteins showing both calcium binding and antimicrobial characteristics. The serum level calprotectin markedly elevated in patients with inflammatory bowel disease, rheumatoid arthritis, as well systemic lupus erythematosus has been suggested to play a prominent role progression pathogenesis these diseases. Aim purpose this study was investigate ankylosing spondylitis (AS) its association disease activity other clinical...

10.1097/jim.0000000000000095 article EN Journal of Investigative Medicine 2014-08-01

Recognition of electroneutral Lewis bases and anions in aqueous media is extremely difficult. We show that fluorescent coordinatively unsaturated metal complexes can recognize various while providing an easy-to-detect fluorescence response. This approach applied to the detection adrafinil, a banned performance-enhancing drug.

10.1039/c6cc03640f article EN Chemical Communications 2016-01-01

The purpose of this study was to investigate the effect carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats.Twenty-four male rats were equally divided into three groups: group I, control treatment; II, MTX-treated; and III, MTX+CAR-treated. A single dose CAR (73 mg/kg) administered intraperitoneally III first day experiment a MTX (20 groups II second experiment. Blood samples kidney tissue obtained from each animal 8 for measurement malondialdehyde (MDA), total oxidant status...

10.25011/cim.v37i1.20865 article EN Clinical and investigative medicine 2014-02-01

In this experimental study, we developed lateral flow immunoassay strips for the detection of <italic>Escherichia coli</italic>.

10.1039/c7ay02974h article EN Analytical Methods 2018-01-01

Objective: This study aims to examine the overall and domain-specific quality of life in patients with stroke identify variables predicting after stroke.Material Methods: A total 104 sufficient cognitive functions having hemiplegia because cerebrovascular accident 108 controls were included this study.Demographic clinical features recorded.The Barthel Index (BI) Functional Ambulation Category scale employed assess functional state patients.Quality was evaluated by Short Form 36 (SF-36)...

10.5152/tftrd.2015.80090 article EN Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 2015-08-04

Behçet's disease (BD) is an inflammatory with multisystem chronic vasculitis. The characterized by attacks of oral and genital ulcerations, skin lesions, arthritis, uveitis deep vein thrombosis. main histopathological feature known to be vascular change. Calprotectin (MRP8/MRP14) has been identified as important alarmin that expressed activated phagocytes, granulocytes, monocytes endothelial cells, recognized toll-like receptors, induces a thrombogenic response in human microvascular...

10.3109/00365513.2014.984319 article EN Scandinavian Journal of Clinical and Laboratory Investigation 2014-12-04

This study was performed to investigate serum prolidase enzyme activity and oxidative stress in patients diagnosed with fibromyalgia (FM).The population consisted of 40 a previous diagnosis FM 30 healthy subjects. We measured activity, total antioxidant status (TAS), (TOS), index (OSI), paraoxonase-1 (PON-1) levels.On average, were within 3.2 years symptom onset, had mean 14 tender points. There no significant differences between controls age, body mass index, TAS, or PON-1 levels. However,...

10.1179/1351000213y.0000000079 article EN Redox Report 2014-01-03

In this study, an electrochemical DNA biosensor was developed using a straightforward methodology to investigate the interaction of indinavir with calf thymus double-stranded deoxyribonucleic acid (ct-dsDNA) for first time. The decrease in oxidation signals deoxyguanosine (dGuo) and deoxyadenosine (dAdo), measured by differential pulse voltammetry, upon incubation different concentrations can be attributed binding mode ct-dsDNA. currents dGuo dAdo peaks decreased linearly concentration range...

10.1016/j.jpha.2020.08.004 article EN cc-by-nc-nd Journal of Pharmaceutical Analysis 2020-08-10

ABSTRACT Colorimetric silver nanoparticle sensor was developed for determination of aminoglycosides in milk. Silver nanoparticles were synthesized by using sodium borohydride as reducing agent and dodecyl sulfate stabilizer. Yellow color turned into orange red proportion to the concentrations analytes. Quantitative analyses performed decrease absorbance at 394 nm. Linear ranges 20–60 ng mL−1, 23–60 60–100 mL−1 gentamicin, tobramycin, amikacin, respectively. The method optimized terms pH,...

10.1080/00387010.2013.845577 article EN Spectroscopy Letters 2013-10-11

This paper describes a lipoic acid capped europium nanoparticle-based assay for the fluorimetric detection of primary amines.

10.1039/c4ay02957g article EN Analytical Methods 2014-12-19

Tri-serine tri-lactone based C3 symmetry fluorescent sensors were synthesized. Citrate is shown to bind sensors, while displaying an increase in fluorescence intensity for the sensor with thiourea and a quenching sulfonamide. Information-rich responses of enable us discriminate structurally similar anions, including mono-, di- tri-carboxylates 100% correct classification. A simple two-sensor array enables determination concentration citrate urine without any sample preparation high accuracy...

10.1039/c5cc08759g article EN Chemical Communications 2015-11-30

Two fluorometric sensors based on the tri-serine tri-lactone scaffold and thiourea or sulfonamide moieties serving as hydrogen bond donors allowing for anion binding are described. The sensor utilizing a recognition moiety shows fluorescence enhancement while with quenching upon addition of phosphates. Sensor arrays composed two able to discriminate structurally similar organic phosphates in presence interferents human blood serum. quantitative analysis ATP serum high accuracy (the root mean...

10.1039/c6ob01378c article EN Organic & Biomolecular Chemistry 2016-01-01

Abstract Background Tacrolimus is a CYP 3A4 inhibitor and can alter colchicine metabolism. In this study, we aimed to evaluate plasma levels in different stages of kidney disease as well transplant ( KT x) recipients using tacrolimus. Method This study included six familial Mediterranean fever FMF ) patients with normal glomerular filtration rate GFR controls, three low , on hemodialysis HD ), who were x After three‐d washout period, measured at 0 (pre‐dose), one, two, four, eight, 24 h...

10.1111/ctr.12448 article EN Clinical Transplantation 2014-08-14

Objective: Low back pain [LBP] is an important health issue due the diagnosis and treatment expenses loss of workforce it leads to. Biomechanical changes in vertebral column caused by lumbosacral angles [LSAs] may lead to LBP. The purpose this study was assess body mass index [BMI] LSAs patients with LBP investigate association between LBP, BMI.Methods: Lumbar lordotic angle [LLA], LSA, sacro-horizontal [SHA] sacral inclination [SIA] were measured 117 chronic 85 healthy normal controls...

10.3109/10582452.2014.907855 article EN Journal of Musculoskeletal Pain 2014-05-22

The aim of the present study was to emphasize collagen turnover in 2 most common chronic inflammatory rheumatic diseases by evaluating serum prolidase activity (SPA) ankylosing spondylitis (AS) and rheumatoid arthritis (RA). 30 patients who met modified New York Criteria for classification AS, 29 2010 Rheumatoid Arthritis Classification RA, 31 healthy controls were enrolled study. Serum samples collected SPA measured a spectrophotometric method. comparison these 3 groups statistically...

10.4137/cmamd.s12602 article EN Clinical Medicine Insights Arthritis and Musculoskeletal Disorders 2013-01-01
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