A5037981258- Seaweed-derived Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- Echinoderm biology and ecology
- Microbial Metabolites in Food Biotechnology
- Glioma Diagnosis and Treatment
- Algal biology and biofuel production
- Polysaccharides Composition and Applications
- Cancer Cells and Metastasis
- Marine Bivalve and Aquaculture Studies
- Aluminum toxicity and tolerance in plants and animals
- Cephalopods and Marine Biology
- Aquaculture Nutrition and Growth
- Marine Sponges and Natural Products
- Advanced Cellulose Research Studies
- Biochemical effects in animals
- Digestive system and related health
- Adsorption and biosorption for pollutant removal
- Glycosylation and Glycoproteins Research
- Food Industry and Aquatic Biology
- Neuroblastoma Research and Treatments
- Environmental Chemistry and Analysis
- Marine Biology and Environmental Chemistry
- Marine and coastal plant biology
- Phytochemical and Pharmacological Studies
- Hydrogels: synthesis, properties, applications
Far Eastern Federal University
2013-2023
A.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences
2008-2023
Russian Academy of Sciences
1982-2011
Vladivostok State Medical University
2001-2008
Development Agency of Serbia
1996-2006
Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences
2001-2006
Cerium binding activity of three different water soluble pectin compounds origin was studied in a batch sorption system. The Langmuir, Freundlich and BET models were adopted to describe the reactions between metal ions molecules. Langmuir model provided best fit. Within pH range from 4.0 6.0, largest amount cerium bound by isolated seagrass Phylospadix iwatensis comparison extracted Zostera marina obtained citrus peel (commercial grade). constants also highest for samples P. iwatensis....
Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from known pro-inflammation properties some pharmacological activity, carrageenans can also strongly bind hold metal ions. This property be used for creation of the new drugs elimination metals body or targeted delivery these ions healing purposes. Metal binding activity different aqueous solutions containing Y3+ Pb2+ was studied a batch sorption system. The uptake by is...
Abstract Pro-proliferative oncogenic signaling is one of the hallmarks cancer. Specific targeting such pathways main approaches to modern anti-cancer drug discovery, as opposed more traditional search for general cytotoxic agents. Natural products, especially from marine sources, represent a largely untapped source chemical diversity, which so far have mostly been screened cytotoxicity. Here we present pioneering pipeline high-throughput screening marine-based activities targeted against Wnt...
The carrageenans isolated from red algae demonstrated a variety of activities antiviral and immunomodulatory to antitumor. diverse structure sulfation profile provide great landscape for drug development. In this study, we isolated, purified structurally characterized κo- λo- oligosaccharides the marine Chondrus armatus. We further examined tumor suppressive activity both in gastrointestinal cancer models. Thus, using MTT assay, could demonstrate pronounced antiproliferative effect KYSE-30...
Glioblastoma multiforme is an invasive malignant glial brain tumor with a poor prognosis for patients. The primary reasons that lead to the development of treatment resistance are associated cells infiltrating parenchyma and specific properties stem cells. A crucial research area in medical science search effective agents able act on these targets. Fascaplysin alkaloids possess potent antitumor activity. Modern methods targeted delivery drugs reveal extensive possibilities terms clinical use...
A Pacific brittle star Ophiura sarsii has previously been shown to produce a chlorin (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (ETPA) (1) with potent phototoxic activities, making it applicable photodynamic therapy. Using extensive LC-MS metabolite profiling, molecular network analysis, and targeted isolation de novo NMR structure elucidation, we herein identify five additional compounds from O. its deep-sea relative ooplax:...
Exposure to environmental lead remains a widespread problem in most industrialized countries. Usage of modern agents purposed for elimination heavy metals as well therapy and prevention chronic poisoning does frequently result toxic signs. Dietary nonstarch polysaccharides were suggested be effective when used this purpose. The present study was conducted estimate metal binding capacity effects calcium salts pectate alginate on absorption, distribution, removal with feces. Under vitro...
The purpose of this study was to investigate the pharmacological effects calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. included two experiments. In first experiment animals were given daily CCL4 through gavage for 7 days and then 10, 50, or 250 mg/kg b.w. 21 days. increased bilirubin level, enhanced alanine aspartate aminotransferase activity plasma reduced liver glycogen content induced by partly normalized administration a dose-dependent manner. addition,...