A5064854782- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Microscopic Colitis
- Psoriasis: Treatment and Pathogenesis
- HIV Research and Treatment
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
Centre de Recherche en Cancérologie de Lyon
2017-2024
Université Claude Bernard Lyon 1
2017-2024
Centre National de la Recherche Scientifique
2017-2024
Centre Léon Bérard
2017-2024
Inserm
2017-2024
Cancer Research Center
2022-2023
Providence Portland Medical Center
2022
CD4+ Th cells play a key role in orchestrating immune responses, but the identity of involved antitumor response remains to be defined. We analyzed cell infiltrates head and neck squamous carcinoma colorectal cancers identified subset distinct from FOXP3+ Tregs that coexpressed programmed death 1 (PD-1) ICOS. These tumor-infiltrating lymphocyte (CD4+ TILs) had tissue-resident memory phenotype, were present MHC class II-rich areas, proliferated tumor, suggesting local antigen recognition. The...
Highlights•Limited metabolite availability results in cellular stress•Cellular stress enhances Th17 cell polarization•Cellular induces de novo differentiation•Cellular can substitute for TGF-β differentiationSummaryT helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting stress, such as low oxygen, glucose, isotonic particularly enhance the generation of cells. Pharmacological inhibition reduces differentiation while...
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site tumor development. However, whether this multifactorial oncogenic process, which commonly in intestines, can be initiated a specific immune cell population is unclear. Here, we show an intestinal T subset, derived from interleukin-17 (IL-17)-producing helper (T
Abstract Both identity and plasticity of CD4 T helper (Th) cells are regulated in part by epigenetic mechanisms. However, a method that reliably readily profiles DNA base modifications is still needed to finely study Th cell differentiation. Cytosine methylation (5mC) cytosine hydroxymethylation (5hmC) identify stable phenotypes but their potential characterize intermediate transitions has not yet been evaluated. To assess transition states cells, we developed new profile using cas9-targeted...
Abstract Murine peripheral lymph node TCR γδ T cells have been divided into type 1 and 17 functional categories based on phenotypic markers. Localized in the gut epithelial barrier, intestinal intraepithelial lymphocytes (iIEL) constitute a peculiar subset of involved homeostasis. However, whether iIEL obey 1/type dichotomy is unclear. Using both global transcriptional signatures expression cell surface markers, we reveal that murine compose distinct population, expressing ∼1000 specific...
<h3>Background</h3> CD4 T helper (Th) cells play a key role in orchestrating immune responses, but the identity of Th involved response against cancer remains to be defined. <h3>Methods</h3> To better define composition infiltrating human solid tumors, we analyzed phenotype 22 patients with head and neck squamous cell carcinoma 16 microsatellite stable colorectal by high dimensional flow cytometry. In addition, determined their spatial location cellular interactions tumor microenvironment...
Abstract Both identity and plasticity of CD4 T helper (Th) cells are regulated in part by epigenetic mechanisms. However, a method that reliably readily profiles DNA base modifications is still needed to finely study Th cell differentiation. Cytosine methylation CpG context (5mCpG) cytosine hydroxymethylation (5hmCpG) identify stable phenotypes, but their potential characterize intermediate transitions has not yet been evaluated. To assess transition states cells, we developed profile using...