A5005659084- Bipolar Disorder and Treatment
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Sleep and related disorders
- Mental Health Research Topics
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Pain Management and Treatment
- Advanced MRI Techniques and Applications
- Cognitive Abilities and Testing
- Olfactory and Sensory Function Studies
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Migraine and Headache Studies
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2023
IRCCS Ospedale San Raffaele
1996-2023
Vita-Salute San Raffaele University
2006-2023
San Raffaele University of Rome
1991-2020
University of Milan
1991-2000
Recent studies showed that a polymorphism (T to C nucleotide substitution) in the 3' flanking region of human CLOCK gene is associated with diurnal preferences healthy subjects, higher "eveningness" subjects carrying at least one copy allele. We investigated possible role regulation mood fluctuations during major depressive episode. Sample (n = 101) was collected, context previously reported trials, among patients affected by bipolar disorder type I, episode without psychotic features, free...
Depressive insomnia and diurnal fluctuations of mood activity are core clinical features disorders. Here we studied the effect CLOCK 3111 T/C SNP (rs1801260) on actimetric recorded nocturnal sleep 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers C allele had a similar degree severity depression, but showed higher levels in evening, delayed onset (mean 79 min later), reduced amount during night 75 less). Ongoing lithium treatment significantly interacted with rs1801260...
Article Abstract Background: Drug resistance remains a persistent source of morbidity and mortality for patients with bipolar depression. A growing number clinical studies support the usefulness chronotherapeutic interventions, such as total sleep deprivation (TSD) light therapy (LT), in treatment nonresistant Method: To investigate TSD plus LT drug-resistant depression, we treated 60 inpatients 1 week repeated combined ongoing antidepressants lithium salts. All had DSM-IV diagnosis I...
OBJECTIVE: A functional polymorphism in the transcriptional control region upstream of coding sequence 5-hydroxytryptamine transporter (5-HTT) has been reported. This shown to influence antidepressant response fluvoxamine and paroxetine. The authors tested hypothesis that allelic variation 5-HTT-linked polymorphic (5-HTTLPR) could depressed patients total sleep deprivation. METHOD: Sixty-eight drug-free inpatients with bipolar depression underwent a night 5-HTTLPR was genotyped these...
Recent findings suggest that extended bed rest and darkness could stabilize mood swings in rapid cycling bipolar patients.We exposed 16 inpatients affected by a manic episode to regimen of 14 h enforced from 6 p.m. 8 a.m. each night for three consecutive days [dark therapy (DT)]. Pattern changes were recorded with the Young Mania Rating Scale (YMRS) compared control group matched age, sex, age at onset, number previous illness episodes duration current episode, treated as usual (TAU).Adding...
The combination of total sleep deprivation (TSD) and light therapy (LT) in bipolar depression causes rapid antidepressant effects, its mechanism action has been hypothesized to involve the enhancement all monoaminergic systems targeted by drugs (serotonin, dopamine, norepinephrine). It is still unknown if clinical effects are paralleled changes biological rhythms. In a before/after design study correlates response, 39 inpatients affected Type I Bipolar Disorder whose current depressive...
Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD).At the beginning study, 20 patients were free psychotropic drugs and had been receiving lithium medication for at least 6 months. Mood was rated on Hamilton Rating Scale Depression before after TSD; perceived mood changes during treatment evaluated with self-administered visual analog scales. Patients undergoing long-term showed a significantly better response to TSD as both scales: 13 (vs....
The purpose of the present study was to compare efficacy clozapine with that chlorpromazine in an open label manner (both given association lithium salts) treatment acute mania. Thirty hospitalized manic patients were entered into study. All met DSM-IV criteria for bipolar disorder, Manic Episode; 27 completed and three dropped noneompliance. duration 3 weeks. Patients randomly assigned two groups: group 1 (n= 15) treated at a mean dose 166 mg/day 2 (n = 12) 310 mg/day. symptomatology rated...
Despite the impact of depression in terms personal suffering and socioeconomic burden, most currently available treatment options are often ineffective. A particularly difficult-to-treat depressive disorder characteristic elderly is vascular depression, a late-life syndrome related to variety potential mechanisms. Transcranial Direct Current Stimulation (tDCS), non-invasive effective somatic approach also showed positive effects on cognitive deficits.We performed double-blind randomized...
Background. Research on mood disorders has progressively focused the study of seasons and in association with them during depressive or manic episodes yet few studies have seasonal fluctuation that characterizes patient's clinical course both an illness episode euthymic periods. Methods. 113 outpatients 46 affected by major recurrent depression 67 bipolar disorder were recruited. We evaluated impact "rhythmical" factors: seasonality, sleep disturbance, chronotype. Patients completed SPAQ+...