A5022105614- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroendocrine regulation and behavior
- Advanced Neuroimaging Techniques and Applications
- Sleep and related disorders
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Ion channel regulation and function
Vita-Salute San Raffaele University
2016-2025
IRCCS Ospedale San Raffaele
2014-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
University of Verona
2025
San Raffaele University of Rome
1999-2015
Neuroscience Institute
2015
Villa Pineta Hospital
2004-2009
In-Q-Tel
2006
European Union
2006
Immune-inflammatory mechanisms are promising targets for antidepressant pharmacology. Immune cell abnormalities have been reported in mood disorders showing a partial T defect. Following this line of reasoning we defined an potentiation treatment with add-on low-dose interleukin 2 (IL-2). IL-2 is T-cell growth factor which has proven anti-inflammatory efficacy autoimmune conditions, increasing thymic production naïve CD4 + cells, and possibly correcting the defect observed disorders. We...
Recent studies showed that a polymorphism (T to C nucleotide substitution) in the 3' flanking region of human CLOCK gene is associated with diurnal preferences healthy subjects, higher "eveningness" subjects carrying at least one copy allele. We investigated possible role regulation mood fluctuations during major depressive episode. Sample (n = 101) was collected, context previously reported trials, among patients affected by bipolar disorder type I, episode without psychotic features, free...
Abstract We investigated the possible effect of 3111T/C CLOCK gene polymorphism on sleep disorders in a sample 620 patients affected by major depressive disorder (MDD) and bipolar (BP). detected significantly higher recurrence initial ( P = 0.0001), middle 0.0009), early 0.0008) insomnia homozygotes for C variant similar trend concerning decreased need BP 0.0074). Other demographic clinical features were found not related with polymorphisms. This preliminary observation leads to hypothesize...
Depressive insomnia and diurnal fluctuations of mood activity are core clinical features disorders. Here we studied the effect CLOCK 3111 T/C SNP (rs1801260) on actimetric recorded nocturnal sleep 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers C allele had a similar degree severity depression, but showed higher levels in evening, delayed onset (mean 79 min later), reduced amount during night 75 less). Ongoing lithium treatment significantly interacted with rs1801260...
Several studies have demonstrated the involvement of 5-HT1A receptors in pathogenesis depression and antidepressant response to SSRIs. A functional new variant promoter region gene was recently reported (−1019 C>G). The aim this study is investigate a possible association between receptor fluvoxamine sample 262 mood-disorder subjects (151 major depressed 111 bipolars) treated with for 6 wk. severity depressive symptoms assessed weekly Hamilton Rating Scale Depression (HAMD). variants did not...
The aim of the present study was to test a possible effect monoamine oxidase A (MAOA) and serotonin receptor 2A (5-HT-2A) gene variants on antidepressant activity fluvoxamine paroxetine in sample major (n = 248) bipolar 195) depressives, with or without psychotic features. total 443 in-patients were treated 300 mg 307) 20–40 136) for 6 wk. severity depressive symptoms assessed weekly Hamilton Rating Scale Depression (HAMD). Allele determined each subject using PCR-based technique. We...
<h3>Context</h3> Total sleep deprivation combined with light therapy causes rapid amelioration of bipolar depression. A polymorphism in the promoter for serotonin transporter influences both antidepressant response and structure function specific brain areas. <h3>Objective</h3> To determine whether or genotype influence pattern neural to a task targeting depressive biases information processing (moral valence decision). <h3>Design</h3> Before-and-after trial studying biologic correlates...
The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences activity. Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine paroxetine, but several other were negative. No study considered drug plasma levels as possible nuisance covariate.We studied fluvoxamine monotherapy.Forty-one consecutively admitted inpatients affected by major depressive episode in course...
Bipolar disorder (BD) is associated with signs of widespread disruption white matter (WM) integrity. A polymorphism in the promoter serotonin transporter (5-HTTLPR) influenced functional cortico-limbic connectivity healthy subjects and course illness BD, short (s) allele being lower connectivity, earlier onset poor response to treatment. We tested effects 5-HTTLPR on diffusion tensor imaging (DTI) measures WM microstructure 140 inpatients, affected by a major depressive episode Italian...
Human genetic studies have implicated specific genes that constitute the molecular clock in manifestation of bipolar disorder (BD). Among involved control system circadian rhythms, CLOCK 3111 T/C and Period3 (PER3) influence core psychopathological features mood disorders, such as patterns sleep, rest, activity, diurnal preference, cognitive performances after sleep loss, age at onset illness, response to antidepressant treatment. Furthermore, several pointed out symptomatology is associated...