A5082501184- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Music Perception
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Language, Metaphor, and Cognition
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Receptor Mechanisms and Signaling
- Attention Deficit Hyperactivity Disorder
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Amino Acid Enzymes and Metabolism
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
IRCCS Ospedale San Raffaele
2021-2023
Azienda Unita' Sanitaria Locale di Parma
2021
San Raffaele University of Rome
2012-2021
Leiden University Medical Center
2021
Background: In the last decade, kynurenine pathway (KP) has gained attention in pathogenesis of cognitive impairment schizophrenia being at croassroad between neuroinflammation and glutamatergic cholinergic neurotransmission.However, clinical findings are scarse conflicting, specific contributions these two systems to neurobiology symptoms far from elucidated.Furthermore, little is known about molecular underpinnings non-pharmacological interventions for improvement, including rehabilitation...
Clozapine is highly effective for treatment-resistant schizophrenia but underutilized due to patient and clinician-related concerns. Little known about the general level of satisfaction with clozapine determinants thereof. We therefore explored in individuals diagnosed spectrum disorders (SSDs). Cross-sectional data from 480 users were used examine demographic clinical factors, including symptom severity, treatment response, adverse drug reactions (ADRs). Patient was self-rated on a scale 1...
Social disability is one of the critical areas known to be a predictor daily functioning in schizophrenia. Recent studies showed that impairments Theory Mind (ToM) contribute real-world social and are more strongly associated with community outcomes than other neuropsychological domains cognition. Several experiments revealed an improving potential cognition targeted training, particularly through introduction verbalisation explicit manipulation information about others' mental states. Based...
Previous works highlighted the relevance of automated language analysis for predicting diagnosis in schizophrenia, but a deeper language-based data-driven investigation clinical heterogeneity through illness course has been generally neglected. Here we used semiautomated multidimensional linguistic innovatively combined with machine-driven clustering technique to characterize speech 67 individuals schizophrenia. Clusters were then compared psychopathological, cognitive, and functional...
Lack of abstract thinking, known as concretism, is a well-known psychopathological feature schizophrenia, reflecting the tendency to adhere concrete aspects stimuli and figurative language comprehension difficulties. Inspired by similarity between 'concretism' defined in psychopathology 'concreteness' linguistics, namely semantic dimension linked perceptual experience, we tested novel hypothesis that impairment deriving meanings related at level, involving concreteness. We analysed speech...
Clozapine is still considered the gold standard for treatment-resistant schizophrenia patients; however, up to 40% of patients do not respond adequately. Identifying potential predictors clinical response this last-line antipsychotic could represent an important goal treatment. Among these, functional polymorphisms involved in dopamine system modulation, known be disrupted schizophrenia, may play a role. We examined COMT Val158Met polymorphism, which plays key role regulation at prefrontal...
Neurocognitive and social cognitive impairments represent important treatment targets in schizophrenia, as they are significant predictors of functional outcome. Different rehabilitative interventions have recently been developed, addressing both psychosocial domains. Although promising, results still heterogeneous outcome not yet identified. In this study we evaluated the efficacy two newly developed interventions, respectively based on use videotaped material comic strips, combined with...
OBJECTIVE Pragmatics refers to the capacity understand speaker's meaning and thus appropriately engage in a conversation. This study aims at establishing role of communicative-pragmatic abilities functioning, defined as set daily activities, schizophrenia. would contribute enrich current models neurocognitive predictors which have so far neglected pragmatics. METHOD One hundred people with schizophrenia underwent comprehensive assessment including cognition, theory mind (ToM), We tested...
To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) excitatory amino acid transporters (EAAT1 2) on cognitive dysfunction that characterizes schizophrenia.One hundred ninety two subjects diagnosed with schizophrenia were assessed Brief Assessment Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test N-back test genotyped for rs4354668 rs2731880.ANOVA showed a significant difference among both EAAT1 EAAT2 genotype groups different...
Intellectual abilities display high heterogeneity in patients with schizophrenia that might depend on the interaction among neurodevelopmental processes, environmental factors and neurocognitive decline. This study aimed to disentangle interplay between intellectual level, cognitive status each domain, a focus speed-related abilities, also including pre-morbid factors. In details, by means of cluster analysis, we identified both global sample 452 affected subsample functioning, different...
Several studies suggested that anxiety can significantly affect the outcome of schizophrenia. Despite this evidence, non-pharmacological interventions targeting are still heterogenous. This study aims to test efficacy a novel training specifically designed target in patients with Innovatively, training, beyond psychoeducation and problem solving, also targets Theory Mind, as it provides coping strategies.Twenty-seven outpatients schizophrenia received rehabilitative (Anxiety Management Group...
Cognitive Remediation represents the best available tool to treat cognitive deficits in schizophrenia and evidence suggests an effect also on global functioning. However, relationship between functional improvement is not yet fully elucidated: do changes need be of a definite size and/or encompass certain number domains order impact daily functioning? This study aims explore role improvement, evaluated both quantitatively qualitatively through use Italian equivalent scores, functioning...