A5056611897- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Respiratory Support and Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Protein Degradation and Inhibitors
- Mechanical Circulatory Support Devices
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Organ Transplantation Techniques and Outcomes
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Lung Cancer Research Studies
- Oral health in cancer treatment
- Neonatal Health and Biochemistry
- Intensive Care Unit Cognitive Disorders
- Glycosylation and Glycoproteins Research
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- Sepsis Diagnosis and Treatment
- Synthesis and Biological Activity
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrhythmias and Treatments
- Renal function and acid-base balance
Kumamoto University Hospital
2017-2024
Kumamoto University
2014-2024
National Center For Child Health and Development
2015-2023
Osaka International Cancer Institute
2023
National Cancer Center
2022
Naga Municipal Hospital
2020
Juntendo University
2019
Osaka University
2019
Japanese Foundation For Cancer Research
2012
Lactate levels within tumors are correlated with metastases, tumor recurrence, and radioresistance, thus apparently contributing to poor outcomes in patients various cancers. We previously reported that high-level production of lactate by multiple myeloma (MM) cell lines is associated LDH activity such MM cells. However, the kinetics remains be studied. In present study, we attempted elucidate mechanism incorporation into Six stromal cells obtained through long-term culture bone marrow...
We conducted a comprehensive time-resolved resonance Raman spectroscopy study of the structures retinal chromophore during photocycle sodium-ion pump Krokinobacter rhodopsin 2 (KR2). succeeded in determining structure unphotolyzed state and K, L, M, O intermediates, by overcoming problem that only small fraction M intermediate is accumulated KR2 photocycle. The Schiff base forms strong hydrogen bond intermediates deprotonated intermediate. Formation this facilitates deprotonation base, which...
No standard treatment has been established for poorly differentiated neuroendocrine carcinoma; the usual recommended is based on strategy small cell lung carcinoma. The aim of this study was to evaluate response carcinoma combination irinotecan and cisplatin in one institution.We retrospectively reviewed 50 patients treated from September 2005 April 2011 our institution. Patients were divided into two stages: limited disease or extensive disease. Forty-four received chemotherapy cisplatin,...
To evaluate the impact of early mobilization after pediatric liver transplantation in PICU.A 70-month retrospective before-after study.Medical and surgical PICU with 20 beds at a tertiary children's hospital.Seventy-five patients 2-18 years old who underwent could walk before surgery.We meticulously planned implemented an intervention, multifaceted framework for practice focusing on multidisciplinary team approach.There was significant increase proportion received physical therapy (66% vs...
Abstract p97/ VCP is an endoplasmic reticulum ( ER )‐associated protein that belongs to the AAA ATP ases associated with diverse cellular activities) ase family. It has a variety of functions including ‐associated degradation, autophagy, and aggresome formation. Recent studies have shown emerging roles its potential as therapeutic target in several cancer subtypes multiple myeloma MM ). We conducted cell‐based compound screen exploit novel small compounds cytotoxic activity cells. Among...
Objective This study aims to evaluate the impact of early mobilization (EM) after pediatric liver transplantation in intensive care unit (PICU). Design A 14-month prospective before and study. Setting Multivalent PICU with 20 beds at a tertiary children's hospital. Patients total 57 patients aged younger than 16 years who received were admitted surgery. Interventions EM project, multifaceted framework for successful practice focusing on multidisciplinary team approach. Measurements Main...
Hypoxia serves a crucial role in the development of drug resistance various cancer cells. Therefore, many attempts targeting hypoxia are underway to overcome mediated by hypoxia. This strategy is useful for multiple myeloma (MM) cells, as MM cells reside within bone marrow, where oxygen concentrations relatively low. A natural compound library was screened identify compounds exerting cytotoxicity under hypoxic conditions. Bufalin exhibited marked normoxic and No significant toxicity observed...
Cuffed endotracheal tubes are being used increasingly for pediatric patients on mechanical ventilation. Appropriate placement of the tube tip Microcuff (Kimberley-Clark, Roswell, GA) is guided by intubation depth mark device. However, inappropriately deep position sometimes observed during PICU stay. The purpose this study was to assess occurrence and risk factors stay.A retrospective cohort study.The at National Center Child Health Development, one largest tertiary hospitals in Japan.All...
Abstract We aimed to identify attributing factors the interindividual variabilities of infusion rates in unfractionated heparin therapy. included patients who required therapy achieve target APTT after cardiac surgery between May 2014 and February 2018. Fifty-nine were included, whom 8 underwent Blalock-Taussig shunt; 27, Glenn procedure; 19, Fontan 3, mechanical valve replacement; 2, Rastelli procedure. Previously reported variables that influenced response treatment initially compared,...
OBJECTIVES: Various methods to insert postpyloric feeding tubes at the bedside have been reported, but optimal method remains controversial. The objective of this study was evaluate effect ultrasound-guided tube placement in critically ill children. DESIGN: Single-center retrospective observational study. SETTING: PICU tertiary children’s hospital. PATIENTS: Children under age 16 who underwent our between September 2017 and August 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A...
Abstract Background Several reports have suggested that routine use of anaerobic blood culture bottles together with aerobic may improve positivity. However, the information is still limited regarding utility in pediatric intensive care unit (PICU), where bacteremia due to bacteria relatively rare. Methods A retrospective observational study was conducted at a PICU tertiary children’s hospital Japan from May 2016 January 2020. Patients aged ≤15 years old bacteremia, for which both and...
The objective of this study is to ascertain the effect clinical experience on pediatric intensive care unit (PICU) residents' learning curve for central venous catheter placement in critically ill children. It was a 58-month retrospective observational study. setting multivalent PICU with 20 beds at tertiary children's hospital. subjects were residents undergoing training placement. During period, 22 enrolled study, and 1,157 procedures (485 venous, 605 peripherally inserted 57 hemodialysis,...
Upper airway obstruction due to foreign body aspiration is rare in adolescents. Diagnosis of the same difficult, and incorrect, delay treatment common patients with no history. Herein, we describe case a 15-year-old boy who presented upper because swallowing chewing gum 4 days before presentation. The patient was initially misdiagnosed scheduled for an emergency tracheotomy. However, this unnecessary surgical procedure narrowly avoided his symptoms resolved after he expelled from airway....