A5045035716- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Cardiac Imaging and Diagnostics
- Hepatitis C virus research
- Fibroblast Growth Factor Research
- Genital Health and Disease
- Parvovirus B19 Infection Studies
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Pancreatic function and diabetes
- Coronary Interventions and Diagnostics
- Histiocytic Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Liver physiology and pathology
First People's Hospital of Foshan
2024-2025
Sun Yat-sen University
2021-2023
Key Laboratory of Guangdong Province
2021-2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2023
Jinan University
2018
Background: Programmed death protein-1 (PD-1) inhibitors and liver transplantation (LT) are alternative treatments for hepatocellular carcinoma (HCC) patients. The application of PD-1 HCC therapy increases T cell immune activity, while immunosuppression is required patients receiving transplantation. More clinical investigation to determine methods balance these treatment effects. In this article, we the first describe characteristics, imaging findings, outcomes 5 LT who had a history...
Traditional liver transplant strategies with cold preservation usually result in ischemia-reperfusion injury (IRI) to the donor liver. Regular normothermic machine perfusion (NMP) livers suffer IRI twice. Here, we aimed introduce a novel technique called continuous NMP without recooling avoid second and its application from extended criteria donors.Seven transplanted following recooling, 7 standard NMP, 14 under static storage (SCS) were included this study. Perioperative outcomes recorded...
The use of steatotic livers in liver transplantation (LT) is controversial. Ischaemia-free (IFLT) has obvious advantages for the recovery allograft function. aim this study was to examine effect grafts with steatosis on outcome and IFLT livers. 360 patients LT were enrolled study. Perioperative characteristics differences among different grades groups, between conventional (CLT) groups analysed. Occurrence early dysfunction (EAD; 50%) primary nonfunction (PNF; 20%) significantly higher...
Background: Ischemia injury affects the recovery of liver allograft function. We propose a novel technique aimed at avoiding second ischemic injury: transplanting an extended criteria donor (ECD) directly under normothermic machine perfusion (NMP) without recooling. studied two cases to evaluate efficacy and safety this technique. Methods: The perioperative characteristics postoperative outcomes recipients ECD livers were analyzed. Both transplantations performed with continuous Result: In...
Surgical techniques of liver transplantation have continually evolved and been modified. We retrospectively analyzed a single-center case series compared the advantages disadvantages each method.Six-hundred seventy-four recipients' perioperative data were assessed stratified by different surgical technics [modified classic (MC), modified piggyback (MPB) (CPB)].MELD score Child-Pugh scores was significantly higher in CPB groups (P=0.008 0.003, respectively). Anhepatic time MPB group longer...
Background T cell-mediated acute rejection(AR) after heart transplantation(HT) ultimately results in graft failure and is a common indication for secondary transplantation. It’s serious threat to transplant recipients. This study aimed explore the novel lncRNA-miRNA-mRNA networks that contributed AR mouse transplantation model. Methods The donor from Babl/C mice was transplanted C57BL/6 with heterotopic implantation abdominal cavity. control group syngeneic same kind of donor....
It is of great significance to confirm reliable indicators for the guidance pretransplant radiofrequency ablation (RFA) hepatocellular carcinoma (HCC). In this study, we aim investigate whether circulating tumor cell (CTC) status a clinical indicator RFA before liver transplantation (LT) in HCC patients. CTC analyses were measured 79 Clinical outcomes including progression-free (PFS) and overall survival (OS) compared analyzed between patients with without RFA. Forty-two detected as...
Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder marked by the uncontrolled proliferation and accumulation of immature myeloid dendritic cells, which originate from bone marrow. Although LCH can involve various organs, including bone, lymph nodes skin, multi‑system liver lung involvement with in adults. A case 49‑year‑old man diagnosed multi‑system, aggressive involving presented present study. The initial radio‑clinic presentation patient was initially suggestive tumor....
Introduction The use of extended criteria donor (ECD) grafts such as with infection hepatitis B virus (HBV) is a potential solution for organ shortage. In this study, we aimed to evaluate the safety and long-term survival utilization surface antigen-positive (HBsAg+) livers in HCC patients using propensity score matching (PSM) analysis. Methods Forty-eight donors HBsAg-positive 279 HBsAg-negative were transplanted enrolled study. PSM analysis used eliminate selection bias. Perioperative data...
BACKGROUND:Abdominal organ cluster transplantation for the treatment of upper abdominal end-stage diseases is a serious conundrum surgeons. CASE REPORT:We performed clinical assessment quadruple (liver, pancreas, duodenum, and kidney) patient with liver disease, post-chronic hepatitis B cirrhosis, uremia, insulin-dependent diabetes mellitus, explored optimal surgical procedure. Simultaneous classic orthotopic liver, pancreas-duodenum, heterotopic renal was on 46-year-old man. The process an...
Background: Immunotherapy has become a new direction of current research because the effect traditional radiotherapy and chemotherapy on clear cell renal carcinoma (ccRCC) is not satisfactory. T proliferation-related genes (TRGs) play pivotal role in tumor progression by regulating proliferation, activity, function immune cells. The purpose our study to construct verify prognostic model based TRGs identify subtypes that may guide treatment through comprehensive bioinformatics analyses....
Abstract Introduction: It is of great significance to confirm reliable indicators for the guidance pretransplant radiofrequency ablation (RFA) hepatocellular carcinoma (HCC). In this study, we aim investigate whether circulating tumor cell (CTC) status clinical indicator RFA before liver transplantation (LT) in HCC patients. Method: 79 patients with CTC analysis were enrolled retrospective study. Clinical outcomes including recurrence and survival compared analyzed between without RFA....