A5104651285- Histone Deacetylase Inhibitors Research
- Muscle Physiology and Disorders
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Muscle metabolism and nutrition
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- Exercise and Physiological Responses
- Epigenetics and DNA Methylation
Sapienza University of Rome
2015-2022
Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells replicate and differentiate in response appropriate stimuli. Epigenetic control is effective at different stages this process. It has been shown that chromatin-remodeling factor HDAC4 able regulate cell proliferation commitment. However, its molecular targets are still uncovered. To explain signaling pathways regulated by cells, we generated tamoxifen-inducible mice with conditional...
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal stem cells. Satellite cell behavior is tightly regulated by surrounding microenvironment, which provides multiple signals derived from local cells and systemic factors. Among epigenetic mechanisms, histone deacetylation has been proved affect regeneration. Indeed, pan-histone deacetylase inhibitors were found improve regeneration, while deletion of 4...
In response to injury, skeletal muscle exhibits high capacity regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion differentiation requires shuttling histone deacetylase 4 (HDAC4), a member class IIa HDACs, from the nucleus cytoplasm consequent activation MEF2-dependent genes (McKinsey 2000). vivo, HDAC4 expression is up-regulated upon suggesting role for protein regeneration. With aim elucidate...