A5050074913- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial Natural Products and Biosynthesis
- Helminth infection and control
- Antibiotic Resistance in Bacteria
- Biofuel production and bioconversion
- Nematode management and characterization studies
- Legume Nitrogen Fixing Symbiosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal and yeast genetics research
VIB-KU Leuven Center for Cancer Biology
2020-2024
KU Leuven
2020-2024
Universität Innsbruck
2024
VIB-KU Leuven Center for Microbiology
2020
is globally recognized as an opportunistic fungal pathogen of high concern, due to its extensive multidrug resistance (MDR). Still, molecular mechanisms MDR are largely unexplored. This the first account genome-wide evolution in
Abstract Candida auris is an emergent human fungal pathogen of growing concern due to common drug resistance all major antifungal classes. Although amphotericin B (AMB) has been detected in 30 60% clinical isolates C. , mechanisms AMB remain poorly characterized. Here we present a large-scale investigation how can be acquired through genetic adaptation. We typed 441 vitro and vivo evolved lineages from four AMB-susceptible strains different clades. show great diversity responses with...
Abstract Candida auris is globally recognized as an opportunistic fungal pathogen of high concern, due to its extensive multidrug-resistance (MDR). Still, molecular mechanisms MDR are largely unexplored. This the first account genome wide evolution in C. obtained through serial vitro exposure azoles, polyenes and echinocandins. We show stepwise accumulation multiple novel mutations genes known unknown antifungal drug resistance, albeit almost all new for . Echinocandin resistance evolved a...
Candida auris is globally recognized as an opportunistic fungal pathogen of high concern, due to its extensive multidrug-resistance (MDR). Still, molecular mechanisms MDR are largely unexplored. This the first account genome wide evolution in C. obtained through serial vitro exposure azoles, polyenes and echinocandins. We show stepwise accumulation multiple novel mutations genes known unknown antifungal drug resistance, albeit almost all new for . Echinocandin resistance was accompanied by a...
Abstract S2.5 Rare yeasts, September 21, 2022, 3:00 PM - 4:30 Candida auris (C. auris) is a recently emerged human fungal pathogen of growing concern due to its ability acquire extensive multidrug resistance (MDR) all four antifungal drug classes. The unprecedented extent MDR in C. auris, suggests accelerated evolution, novel mechanisms resistance, and/or potential fitness compensation. Despite being the first fungus be officially considered an urgent antimicrobial threat by CDC (US),...
<title>Abstract</title> The increased prevalence of antifungal drug resistance and emergence multidrug-resistant species such as <italic>Candida auris</italic> represent a global public health threat. By mapping susceptibility responses experimentally evolved <italic>C. across diverse antifungals, we found trends cross-resistance (XR) collateral sensitivity (CS) show that CS can reduce development through cycling combination therapy, providing promising direction for future research.