A5084902191- Evolutionary Game Theory and Cooperation
- Evolutionary Psychology and Human Behavior
- Experimental Behavioral Economics Studies
- Language and cultural evolution
- Innovations in Medical Education
- Animal Behavior and Reproduction
- Evolution and Genetic Dynamics
- Clinical Reasoning and Diagnostic Skills
- Antifungal resistance and susceptibility
- Reflective Practices in Education
- Plant and animal studies
- Prostate Cancer Treatment and Research
- Cultural Differences and Values
- Helminth infection and control
- Pain Mechanisms and Treatments
- Vehicle Routing Optimization Methods
- Opinion Dynamics and Social Influence
- Human Resource and Talent Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Musculoskeletal pain and rehabilitation
- Race, Genetics, and Society
- Game Theory and Applications
- Cognitive Abilities and Testing
- Surgical site infection prevention
- Facility Location and Emergency Management
KU Leuven
2016-2024
Erasmus University Rotterdam
2020-2023
Tergooi
2014-2023
Erasmus MC
2012-2021
University of Groningen
2010-2017
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2010-2016
Google (United States)
2015
Delft University of Technology
2013
University of Edinburgh
2010
University of Amsterdam
2009
<h3>Importance</h3> DCVAC/PCa is an active cellular immunotherapy designed to initiate immune response against prostate cancer. <h3>Objective</h3> To evaluate the efficacy and safety of plus chemotherapy followed by maintenance treatment in patients with metastatic castration-resistant cancer (mCRPC). <h3>Design, Setting, Participants</h3> The VIABLE double-blind, parallel-group, placebo-controlled, phase 3 randomized clinical trial enrolled mCRPC among 177 hospital clinics US Europe between...
Significance We report on a two-step decision-making experiment. The first part shows that humans differ consistently in the way they learn from others. Some individuals are success-based learners, who try to identify successful peers and mimic their behavior. Others frequency-based tend adopt most frequent behavior group. second reveals these differences social learning have important consequences for outcome of interactions. In situations where participants had choose between selfish...
Abstract Candida auris is an emergent human fungal pathogen of growing concern due to common drug resistance all major antifungal classes. Although amphotericin B (AMB) has been detected in 30 60% clinical isolates C. , mechanisms AMB remain poorly characterized. Here we present a large-scale investigation how can be acquired through genetic adaptation. We typed 441 vitro and vivo evolved lineages from four AMB-susceptible strains different clades. show great diversity responses with...
Cabazitaxel and abiraterone have both received approval for treating metastatic castrate‐resistant prostate cancer (mCRPC) patients after first‐line docetaxel therapy. In the cabazitaxel sequential treatment (CAST) study, clinical outcome of docetaxel‐treated mCRPC treated sequentially with was studied. Data were collected retrospectively from at 12 hospitals across Netherlands who initiated and/or before December 2012. Primary measure overall survival (OS); secondary measures...
The migration of people between different cultures has affected cultural change throughout history. To understand this process, cross-cultural psychologists have used the 'acculturation' framework, classifying 'acculturation orientations' along two dimensions: willingness to interact with culturally individuals, and inclination retain own identity ('cultural conservatism'). Here, using a evolution approach, we construct dynamically explicit model acculturation. We show that multicultural...
Studies aimed at explaining the evolution of phenotypic traits have often solely focused on fitness considerations, ignoring underlying mechanisms. In recent years, there has been an increasing call for integrating mechanistic perspectives in evolutionary but it is not clear whether and how mechanisms affect course outcome evolution. To study this, we compare four implementations two well-studied models cooperation, Iterated Prisoner's Dilemma (IPD) game Snowdrift (ISD) game. Behavioural...
Individuals face many types of social interactions throughout their lives, but they often cannot perfectly assess what the consequences actions will be. Although it is known that unpredictable environments can profoundly affect evolutionary process, remains unclear how uncertainty about nature shapes evolution behaviour. Here, we present an simulation model, showing even intermediate leads to simple cooperation strategies disregard information interaction ('social heuristics'). Moreover, our...
Abstract The potential of reflection for learning and development is broadly accepted across the medical curriculum. Our understanding how exactly yields its educational promise, however, limited to broad hints at relation between learning. Yet, such essential (re)design education development. In this qualitative study, we used participants’ video-stimulated comments on actual practice identify features that do or not make collaborative valuable participants. doing so, focus aspects...
Abstract Objective Evolutionary theory has shown that seeking out extrapair paternity (EPP) can be a viable reproductive strategy for both sexes in pair‐bonded species, also humans. As yet, estimates of the contemporary or historical EPP rate human population are still rare. In present study, we estimated Dutch over last 400 years and compared with those obtained other populations to determine evolutionary, cultural, socio‐demographic factors influence cuckoldry behavior. Methods We via...
Abstract Repression of competition (RC) within social groups has been suggested as a key mechanism driving the evolution cooperation, because it aligns individual’s proximate interest with group. Despite its enormous potential for explaining cooperation across all levels biological organization, ranging from fair meiosis, to policing in insect societies, sanctions mutualistic interactions between species, there no direct experimental test whether RC favours spread cooperators well‐mixed...
Human ecological success is often attributed to our capacity for social learning, which facilitates the spread of adaptive behaviours through populations. All humans rely on learning acquire culture, but there substantial variation across societies, between individuals and over developmental time. However, it unclear why these differences exist. Here, we present an evolutionary model showing that individual in can emerge if benefits are unpredictable. Unpredictability selects flexible...
Abstract Many experiments on human cooperation have revealed that individuals differ systematically in their tendency to cooperate with others. It has also been shown condition behaviour the overall level of peers. Yet, little is known about how respond heterogeneity cooperativeness neighbourhood. Here, we present an experimental study investigating whether and people heterogeneous a public goods game. We find large majority subjects does group, but they quite different ways. Most contribute...
Abstract Enmeshed in various social structures, humans must often weigh their own interest against the of others—including common groups they belong to. The Public Goods Game (PGG), which succinctly pits individual group interest, has been a staple research into how people make such decisions. It studied many variations, laboratory and (increasingly) online. One defining parameters PGG is marginal per capita return project (MPCR), determines incentive for contributing to relative keeping...
Abstract When physicians do not estimate their diagnostic accuracy correctly, i.e. show inaccurate calibration , errors or overtesting can occur. A previous study showed that physicians’ for easy cases improved, after they received feedback on diagnoses. We investigated whether would also improve from this when were more difficult. Sixty-nine general-practice residents randomly assigned to one of two conditions. In the condition, diagnosed a case, rated confidence in diagnosis, invested...